Protective oral vaccination against infectious salmon anaemia virus in Salmo salar
Author
dc.contributor.author
Caruffo, Mario
Author
dc.contributor.author
Maturana, Carlos
Author
dc.contributor.author
Kambalapally, Swetha
Author
dc.contributor.author
Larenas Herrera, Julio
Author
dc.contributor.author
Tobar, Jaime
Admission date
dc.date.accessioned
2016-11-25T15:29:56Z
Available date
dc.date.available
2016-11-25T15:29:56Z
Publication date
dc.date.issued
2016
Cita de ítem
dc.identifier.citation
Fish & Shellfish Immunology 54 (2016) 54-59
es_ES
Identifier
dc.identifier.other
10.1016/j.fsi.2016.03.009
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/141470
Abstract
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Infectious salmon anemia (ISA) is a systemic disease caused by an orthomyxovirus, which has a significant economic impact on the production of Atlantic salmon (Salmo salar). Currently, there are several commercial ISA vaccines available, however, those products are applied through injection, causing stress in the fish and leaving them susceptible to infectious diseases due to the injection process and associated handling. In this study, we evaluated an oral vaccine against ISA containing a recombinant viral hemagglutinin-esterase and a fusion protein as antigens. Our findings indicated that oral vaccination is able to protect Atlantic salmon against challenge with a high-virulence Chilean isolate. The oral vaccination was also correlated with the induction of IgM-specific antibodies. On the other hand, the vaccine was unable to modulate expression of the antiviral related gene Mx, showing the importance of the humoral response to the disease survival. This study provides new insights into fish protection and immune response induced by an oral vaccine against ISA, but also promises future development of preventive solutions or validation of the current existing therapies. (C) 2016 Elsevier Ltd. All rights reserved