Hybrid biomaterials based on calcium carbonate and polyaniline nanoparticles for application in photothermal therapy
Author
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Neira Carrillo, Andrónico
Author
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Yslas, Edith
Author
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Yazmin Amar, Marini
Author
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Vásquez Quitral, Patricio
Author
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Sánchez, Marianela
Author
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Riveros, Ana
Author
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Yáñez, Diego
Author
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Cavallo, Pablo
Author
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Kogan Bocian, Marcelo
Author
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Acevedo, Diego
Admission date
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2017-03-01T20:59:58Z
Available date
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2017-03-01T20:59:58Z
Publication date
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2016
Cita de ítem
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Colloids and Surfaces B-Biointerfaces. Volumen: 145 Páginas: 634-642
es_ES
Identifier
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10.1016/j.colsurfb.2016.05.060
Identifier
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https://repositorio.uchile.cl/handle/2250/142907
Abstract
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Inorganic materials contain remarkable properties for drug delivery, such as a large surface area and nanoporous structure. Among these materials, CaCO3 microparticles (CMPs) exhibit a high encapsulation efficiency and solubility in acidic media. The extracellular pH of tumor neoplastic tissue is significantly lower than the extracellular pH of normal tissue facilitating the release of drug-encapsulating CMPs in this area. Conducting polyaniline (PANI) absorbs light energy and transforms it into localized heat to produce cell death. This work aimed to generate hybrid CMPs loaded with PANI for photothermal therapy (PTT). The hybrid nanomaterial was synthesized with CaCO3 and carboxymethyl cellulose in a simple, reproducible manner. The CMP-PANI-Cys particles were developed for the first time and represent a novel type of hybrid biomaterial. Resultant nanoparticles were characterized utilizing scanning electron microscopy, dynamic light scattering, zeta potential, UV-vis, FTIR and Raman spectroscopy. In vitro HeLa cells in dark and irradiated conditions showed that CMP-PANI-Cys and PANI-Cys are nontoxic at the assayed concentrations. Hybrid biomaterials displayed high efficiency for potential PTT compared with PANI-Cys. In summary, hierarchical hybrid biomaterials composed of CMPs and PANI-Cys combined with near infrared irradiation represents a useful alternative in PTT. (C) 2016 Elsevier B.V. All rights reserved.