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Authordc.contributor.authorNeira Carrillo, Andrónico 
Authordc.contributor.authorYslas, Edith 
Authordc.contributor.authorYazmin Amar, Marini 
Authordc.contributor.authorVásquez Quitral, Patricio 
Authordc.contributor.authorSánchez, Marianela 
Authordc.contributor.authorRiveros, Ana 
Authordc.contributor.authorYáñez, Diego 
Authordc.contributor.authorCavallo, Pablo 
Authordc.contributor.authorKogan Bocian, Marcelo 
Authordc.contributor.authorAcevedo, Diego 
Admission datedc.date.accessioned2017-03-01T20:59:58Z
Available datedc.date.available2017-03-01T20:59:58Z
Publication datedc.date.issued2016
Cita de ítemdc.identifier.citationColloids and Surfaces B-Biointerfaces. Volumen: 145 Páginas: 634-642es_ES
Identifierdc.identifier.other10.1016/j.colsurfb.2016.05.060
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/142907
Abstractdc.description.abstractInorganic materials contain remarkable properties for drug delivery, such as a large surface area and nanoporous structure. Among these materials, CaCO3 microparticles (CMPs) exhibit a high encapsulation efficiency and solubility in acidic media. The extracellular pH of tumor neoplastic tissue is significantly lower than the extracellular pH of normal tissue facilitating the release of drug-encapsulating CMPs in this area. Conducting polyaniline (PANI) absorbs light energy and transforms it into localized heat to produce cell death. This work aimed to generate hybrid CMPs loaded with PANI for photothermal therapy (PTT). The hybrid nanomaterial was synthesized with CaCO3 and carboxymethyl cellulose in a simple, reproducible manner. The CMP-PANI-Cys particles were developed for the first time and represent a novel type of hybrid biomaterial. Resultant nanoparticles were characterized utilizing scanning electron microscopy, dynamic light scattering, zeta potential, UV-vis, FTIR and Raman spectroscopy. In vitro HeLa cells in dark and irradiated conditions showed that CMP-PANI-Cys and PANI-Cys are nontoxic at the assayed concentrations. Hybrid biomaterials displayed high efficiency for potential PTT compared with PANI-Cys. In summary, hierarchical hybrid biomaterials composed of CMPs and PANI-Cys combined with near infrared irradiation represents a useful alternative in PTT. (C) 2016 Elsevier B.V. All rights reserved.es_ES
Lenguagedc.language.isoenes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceColloids and Surfaces B-Biointerfaceses_ES
Keywordsdc.subjectNanoparticleses_ES
Keywordsdc.subjectNanocompositeses_ES
Keywordsdc.subjectDrug delivery systemses_ES
Keywordsdc.subjectBiomineralizationes_ES
Keywordsdc.subjectBiological applications of polymerses_ES
Títulodc.titleHybrid biomaterials based on calcium carbonate and polyaniline nanoparticles for application in photothermal therapyes_ES
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorC. R. B.es_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile