Multiphysics modeling of the atrial systole under standard ablation strategies
Author
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Hörmann, Julia M.
Author
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Bertoglio, Cristóbal
Author
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Nagler, Andreas
Author
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Pfaller, Martin R.
Author
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Bourier, Felix
Author
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Hadamitzky, Martin
Author
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Deisenhofer, Isabel
Author
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Wall, Wolfgang A.
Admission date
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2018-03-29T14:32:42Z
Available date
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2018-03-29T14:32:42Z
Publication date
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2017-06
Cita de ítem
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Cardiovascular Engineering and Technology, Vol. 8, No. 2, June 2017 pp. 205–218
es_ES
Identifier
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10.1007/s13239-017-0308-z
Identifier
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https://repositorio.uchile.cl/handle/2250/147084
Abstract
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The aim of this study was to develop a computational framework to compare the impact of standard ablation concepts on the mechanical performance of the atria, since different line combinations cannot be applied in practice to the same patient. For this purpuse, we coupled electro-mechano-hemodynamic mathematical models based on biophysical principles and simulate the contractile performance of the atria. We computed systolic pressures and volumes in two patient-specific atrial geometries (one of normal size and one hypertrophied) with various ablation concepts. We found that our computational model is able to detect the differences in the left atrial contractility and ejection fraction for various electrical activation sequences resulting from different ablation line combinations. We show that multiphysics modeling has the potential to quantify the hemodynamic performance of left atria for different ablation lines, which could be used as additional pre-operative clinical information for the choice of the ablation concept in the future.
es_ES
Patrocinador
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Institute for Advanced Study, Technical University of Munich, as part of the Focus Group "Advanced Cardiac Mechanics Emulator''