Author | dc.contributor.author | Bejarano, Julian | |
Author | dc.contributor.author | Detsch, Rainer | |
Author | dc.contributor.author | Boccaccini, Aldo R. | |
Author | dc.contributor.author | Palza Cordero, Humberto | |
Admission date | dc.date.accessioned | 2019-05-29T13:10:18Z | |
Available date | dc.date.available | 2019-05-29T13:10:18Z | |
Publication date | dc.date.issued | 2017 | |
Cita de ítem | dc.identifier.citation | Journal of Biomedical Materials Research - Part A, Volumen 105, Issue 3, 2017, Pages 746-756 | |
Identifier | dc.identifier.issn | 15524965 | |
Identifier | dc.identifier.issn | 15493296 | |
Identifier | dc.identifier.other | 10.1002/jbm.a.35952 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/168788 | |
Abstract | dc.description.abstract | Novel multifunctional scaffolds for bone regeneration can be developed by incorporation of bioactive glasses (BG) doped with therapeutic and antibacterial metal ions, such as copper (Cu) and zinc (Zn), into a biodegradable polymer. In this context, porous composite materials of biodegradable poly(d, l-lactide) (PDLLA) mixed with sol-gel BG of chemical composition 60SiO(2); 25CaO; 11Na(2)O; and 4P(2)O(5) (mol %) doped with either 1 mol % of CuO or ZnO, and with both metals, were prepared. The cytocompatibility of the scaffolds on bone marrow stromal cells (ST-2) depended on both, the amount of glass filler and the concentration of metal ion, as evaluated by lactate dehydrogenase (LDH) activity, cell viability (water-soluble tetrazolium salt [WST-8]), and by cell morphology (scanning electron microscopy [SEM]) tests. In particular, scaffolds having a filler content of 10 wt % showed the highest cytocompatibility. In addition, compared to the neat polymer, the scaffolds containing Cu promoted the angiogenesis marker (Vascular endothelial growth factor concentration) to a larger extent while scaffolds containing Zn increased the osteogenesis marker (specific alkaline phosphatase-activity). Noteworthy, the scaffolds with both metal ions showed a combined effect on both properties. Cu- and Zn-doped glasses also provided higher antibacterial capacity to PDLLA-based scaffolds against methicillin-resistant S. aureus bacteria than undoped glass. In combination, our results showed that by a proper addition of Cu- and Zn-doped BG to a PDLLA matrix, multifunctional composite scaffolds with enhanced biological activity can be designed for bone tissue regeneration. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 746-756, 2017. | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Wiley | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Source | dc.source | Journal of Biomedical Materials Research - Part A | |
Keywords | dc.subject | Bioactive glasses | |
Keywords | dc.subject | Biodegradable polymer scaffolds | |
Keywords | dc.subject | Bone regeneration | |
Keywords | dc.subject | Copper and zinc ions | |
Keywords | dc.subject | Multifunctional properties | |
Título | dc.title | PDLLA scaffolds with Cu- and Zn-doped bioactive glasses having multifunctional properties for bone regeneration | |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | |
Cataloguer | uchile.catalogador | laj | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |