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Authordc.contributor.authorIllesca, Paola 
Authordc.contributor.authorValenzuela, Rodrigo 
Authordc.contributor.authorEspinosa, Alejandra 
Authordc.contributor.authorEcheverría, Francisca 
Authordc.contributor.authorSoto Alarcón, Sandra A. 
Authordc.contributor.authorOrtiz, Macarena 
Authordc.contributor.authorVidela Cabrera, Luis 
Admission datedc.date.accessioned2019-10-11T17:31:28Z
Available datedc.date.available2019-10-11T17:31:28Z
Publication datedc.date.issued2019
Cita de ítemdc.identifier.citationBiomedicine and Pharmacotherapy, Volumen 109,
Identifierdc.identifier.issn19506007
Identifierdc.identifier.issn07533322
Identifierdc.identifier.other10.1016/j.biopha.2018.11.120
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/171381
Abstractdc.description.abstract© 2018 The Authors Background: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in oxidative stress, pro-inflammatory status and depletion of n-3 long chain polyunsaturated fatty acid. Hydroxytyrosol (HT) is a polyphenol with important cytoprotective effects, and this molecule can modulate the gene expression, transcription factors and enzymatic activity. Objective: Therefore, the purpose of this study was evaluate the anti-inflammatory, anti-oxidant and anti-lipogenic effects of HT supplementation mice and the molecular adaptations involved, on dysfunctional WAT from high-fat diet (HFD)-fed mice. Methods and results: Male C57BL/6 J mice received (i) control diet (10% fat); (ii) control diet + HT (daily doses of 5 mg kg body weight), (iii) HFD (60% fat); or (iv) HFD + HT for 12 weeks. HFD-fed mice exhibited: (i) WAT hypertrophy; (ii) o
Lenguagedc.language.isoen
Publisherdc.publisherElsevier Masson SAS
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceBiomedicine and Pharmacotherapy
Keywordsdc.subjectHydroxytyrosol
Keywordsdc.subjectNF-κB
Keywordsdc.subjectNrf2
Keywordsdc.subjectOxidative stress
Keywordsdc.subjectPPAR-γ
Keywordsdc.subjectWhite adipose tissue
Títulodc.titleHydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile