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Author dc.contributor.author Silva, Sebastián A.
Author dc.contributor.author Maass, Juan C.
Admission date dc.date.accessioned 2019-10-11T17:32:42Z
Available date dc.date.available 2019-10-11T17:32:42Z
Publication date dc.date.issued 2019
Cita de ítem dc.identifier.citation Hearing Research, Volumen 373,
Identifier dc.identifier.issn 18785891
Identifier dc.identifier.issn 03785955
Identifier dc.identifier.other 10.1016/j.heares.2018.12.002
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/171406
Abstract dc.description.abstract © 2018 Elsevier B.V. In mammals, the cochlear sensory epithelium becomes quiescent early during development. After the first postnatal week, there is no cell replacement or proliferation, and severe damage leads to permanent deafness. Supporting cells’ trans-differentiation has been suggested as a way to regenerate cochlear hair cells after damage. However, they are also needed for proper functionality. Cdkn1b (p27 Kip1 ) participates in the cochlear terminal mitosis state achieved during development. Its expression is maintained in adult supporting cells and its postnatal deletion has induced cochlear proliferation in vitro and in vivo. Therefore, its manipulation has been proposed as a feasible way to induce proliferation of supporting cells after birth. Nevertheless, the literature is scarce regarding feasible methods to directly decrease p27 Kip1 in the clinical domain. The effects of p27 Kip1 knockdown using viral vectors are not completely elucidated and no pharmacological approa
Lenguage dc.language.iso en
Publisher dc.publisher Elsevier B.V.
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Hearing Research
Keywords dc.subject Alsterpaullone
Keywords dc.subject cdkn1b protein
Keywords dc.subject Cell proliferation
Keywords dc.subject Inner ear
Keywords dc.subject Labyrinth supporting cells
Keywords dc.subject shRNA
Título dc.title p27 Kip1 down-regulation as achieved by two clinically feasible means did not induce proliferation of supporting cells in the rat neonatal cochlea in vivo
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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