Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer
Author
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Román, Juan José Mora
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Del Campo, Miguel
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Villar, Javiera
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Paolini, Francesca
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Curzio, Gianfranca
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Venuti, Aldo
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Jara, Lilian
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Ferreira, Jorge
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Murgas, Paola
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Lladser, Alvaro
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Manubens, Augusto
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Becker, María Inés
Admission date
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2019-10-15T12:25:35Z
Available date
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2019-10-15T12:25:35Z
Publication date
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2019
Cita de ítem
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Journal of Immunology Research, Volumen 2019,
Identifier
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23147156
Identifier
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23148861
Identifier
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10.1155/2019/7076942
Identifier
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https://repositorio.uchile.cl/handle/2250/171731
Abstract
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Mollusk hemocyanins have been used for decades in immunological and clinical applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the treatment of superficial bladder cancer, as carriers/adjuvants of tumor-associated antigens in cancer vaccine development and as adjuvants to dendritic cell-based immunotherapy, because these glycoproteins induce a bias towards Th1 immunity. Here, we analyzed the preclinical therapeutic potential of the traditional keyhole limpet hemocyanin (KLH) and two new hemocyanins from Concholepas concholepas (CCH) and Fissurella latimarginata (FLH) in mouse models of oral squamous cell carcinoma. Due to the aggressiveness and deadly malignant potential of this cancer, the hemo