Quantification of immunoglobulin G against trypanosoma cruzi in individuals with chronic chagas disease treated with nifurtimox and evaluated in prolonged follow-up
Author
dc.contributor.author
Muñoz, Gabriela
Author
dc.contributor.author
Vergara, Camilo
Author
dc.contributor.author
Martínez, Gabriela
Author
dc.contributor.author
Apt, Werner
Author
dc.contributor.author
Zulantay, Inés
Admission date
dc.date.accessioned
2019-10-15T12:25:36Z
Available date
dc.date.available
2019-10-15T12:25:36Z
Publication date
dc.date.issued
2019
Cita de ítem
dc.identifier.citation
Korean Journal of Parasitology, Volumen 57, Issue 1, 2019, Pages 39-42
Identifier
dc.identifier.issn
17380006
Identifier
dc.identifier.issn
00234001
Identifier
dc.identifier.other
10.3347/kjp.2019.57.1.39
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/171733
Abstract
dc.description.abstract
In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
Lenguage
dc.language.iso
en
Publisher
dc.publisher
Korean Society for Parasitology and Tropical Medicine
Quantification of immunoglobulin G against trypanosoma cruzi in individuals with chronic chagas disease treated with nifurtimox and evaluated in prolonged follow-up