Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies
Author
dc.contributor.author
Urrutia, Daniela N.
Author
dc.contributor.author
Caviedes, Pablo
Author
dc.contributor.author
Ruiz Mardones, Rodrigo
Author
dc.contributor.author
Minguell, José J.
Author
dc.contributor.author
Vega-Letter, Ana Maria
Author
dc.contributor.author
Jofre, Claudio M.
Admission date
dc.date.accessioned
2019-10-15T12:25:40Z
Available date
dc.date.available
2019-10-15T12:25:40Z
Publication date
dc.date.issued
2019
Cita de ítem
dc.identifier.citation
PLoS ONE, Volumen 14, Issue 3, 2019,
Identifier
dc.identifier.issn
19326203
Identifier
dc.identifier.other
10.1371/journal.pone.0213032
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/171757
Abstract
dc.description.abstract
Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the treatment of post-traumatic and hereditary diseases of the central nervous system (CNS). In order to attain an ideal source of adult MSCs for the treatment of CNS diseases, adipose tissue, bone marrow, skin and umbilical cord derived MSCs were isolated and studied to explore differences with regard to neural differentiation capacity. In this study, we demonstrated that MSCs from several tissues can differentiate into neuron-like cells and differentially express progenitors and mature neural markers. Adipo
Biochemistry, Genetics and Molecular Biology (all)
Keywords
dc.subject
Agricultural and Biological Sciences (all)
Título
dc.title
Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies