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Authordc.contributor.authorFox, Christopher 
Authordc.contributor.authorCivallero, Mónica 
Authordc.contributor.authorYoung-Hyeh, Ko 
Authordc.contributor.authorManni, Martina 
Authordc.contributor.authorSkrypets, Tetiana 
Authordc.contributor.authorPileri, Stefano 
Authordc.contributor.authorKim, Seok Jin 
Authordc.contributor.authorCabrera, María Elena 
Authordc.contributor.authorShustov, Andrei 
Authordc.contributor.authorChiattone, Carlos 
Authordc.contributor.authorHorwitz, Steven 
Authordc.contributor.authorDlouhy, Ivan 
Authordc.contributor.authorSpina, Michele 
Authordc.contributor.authorHitz, Felicitas 
Authordc.contributor.authorMontoto, Silvia 
Authordc.contributor.authorNagler, Arnon 
Authordc.contributor.authorMartínez, Virginia 
Authordc.contributor.authorDe Souza, Carmino 
Authordc.contributor.authorFernández Álvarez, Rubén 
Authordc.contributor.authorBallova, Veronika 
Authordc.contributor.authorGabús, Raul 
Authordc.contributor.authorInghirami, Giorgio 
Authordc.contributor.authorFederico, Massimo 
Authordc.contributor.authorKim, Won Seog 
Cita de ítemdc.identifier.citationLancet Haematology 7(4) E284-E294 Apr 2020es_ES
Abstractdc.description.abstractBackground Extranodal natural killer (NK) T-cell lymphoma (ENKTL) is a unique clinicopathological entity, typically associated with poor survival outcomes. Most published data have come from east Asian study groups, with little information available from international cohorts. The effects of treatment advances on routine clinical practice across continental territories has not been cleat We aimed to improve understanding of the clinical characteristics and outcomes of patients with ENKTL. Methods We did a substudy of patients with ENKTL from the T-cell Project, a global prospective cohort study. The T-cell Project registered consecutively diagnosed adults (>18 years) with newly diagnosed, untreated mature T-cell or NK lymphomas (WHO 2001 or 2008 classifications) from 74 centres in 13 countries (in Asia, Europe, North America, and South America). In total, 1695 patients with mature T-cell or NK lymphomas were enrolled between Oct 12, 2006 and Feb 28, 2018 in the T-cell Project. The first patient with ENKTL was enrolled on Feb 15, 2007, and the last on May 26, 2017. Data on baseline characteristics, first-line treatment, treatment response, and survival outcomes were recorded in a central database (locked March 30, 2019). The primary outcome was 5-year overall survival. The T-cell Project is registered on, NCT01142674. Findings 166 patients were diagnosed with ENKTL, comprising 11% of 1553 eligible registered cases and distributed across 40 participating centres in four continents. At a median follow-up of 44 months (IQR 20-61), overall survival at 5 years was 54% (95% CI 44-63) in patients with nasal disease (n=98) and 34% (27-46) in patients with extranasal disease (n=68). Interpretation To our knowledge, this study presents the largest international cohort of patients with ENKTL We describe a clinically significant improvement in the survival of patients with ENKTL treated in routine clinical practice over the past decade, likely to be attributable to the increasing use of treatment protocols specific for ENKTL.es_ES
Patrocinadordc.description.sponsorshipFondazione Cassa di Risparmio di Modena (Modena, Italy) Associazione Angela Serra per la Ricerca sul Cancro (Modena, Italy) Fondazione Italiana Linfomi (Alessandria, Italy) Allos Therapeutics Spectrum Pharmaceuticals Associazione Italiana per la Ricerca sul Cancro (AIRC) US National Cancer Institute at the National Institutes of Health (Bethesda, MD, USA): CCSG P30 CA008748 Associazione Italiana per la Ricerca sul Cancro (AIRC): 10007, 20198es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceLancet Haematologyes_ES
Keywordsdc.subjectDiagnosed stage IVes_ES
Títulodc.titleSurvival outcomes of patients with extranodal natural-killer T-cell lymphoma: a prospective cohort study from the international T-cell Projectes_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Indexationuchile.indexArtículo de publicación ISI
Indexationuchile.indexArtículo de publicación SCOPUS

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