Refractory epilepsy associated with anti-ribosomal P antibodies successfully treated with topiramate
Author
dc.contributor.author
Uribe San Martín, R.
Author
dc.contributor.author
Ciampi, E.
Author
dc.contributor.author
Cruz, J. P.
Author
dc.contributor.author
Vásquez, M.
Author
dc.contributor.author
Cárcamo, C.
Admission date
dc.date.accessioned
2020-05-08T21:30:35Z
Available date
dc.date.available
2020-05-08T21:30:35Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Journal of Neuroimmunology 340 (2020) 577144
es_ES
Identifier
dc.identifier.other
10.1016/j.jneuroim.2020.577144
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/174599
Abstract
dc.description.abstract
We report the case of a 25-year-old woman who developed temporal lobe epilepsy associated with systemic lupus erythematosus (SLE). Serum and cerebrospinal fluid samples showed high titers of anti-ribosomal P (anti-P) antibodies with negative anti-NMDAR antibodies. She was receiving prednisone and azathioprine, with normalization of SLE serum markers, but without changes in titers of anti-P antibodies. No seizure control was achieved using valproic acid, levetiracetam and lamotrigine. However, she had a selective response to topiramate, an AMPAR blocker, maintained during 6 years of follow-up. We discuss the pathophysiology of this autoimmune epilepsy associated with high titer anti-P antibodies