Calcium & ROS: two orchestra directors for the requiem of death
Author
dc.contributor.author
San Martín Rovirosa, Carol
Author
dc.contributor.author
Böhme, Daniela
Author
dc.contributor.author
Rojas Rivera, Diego
Admission date
dc.date.accessioned
2020-06-03T14:42:29Z
Available date
dc.date.available
2020-06-03T14:42:29Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Cell Calcium 85 (2020) 102113
es_ES
Identifier
dc.identifier.other
10.1016/j.ceca.2019.102113
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/175168
Abstract
dc.description.abstract
Tumor necrosis factor alpha (TNF) triggers regulated necrosis of mycobacterium-infected macrophages through of mitochondrial reactive oxygen species (mitoROS) production in a RIPK1/3-dependent manner. To explain that, Roca and colleagues describe an inter-orgallenar circuit which involves the lysosomal ceramide production, mitoROS, BAX activation and RyR Ca2+ efflux from the endoplasmic reticulum into the mitochondrion.
es_ES
Patrocinador
dc.description.sponsorship
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT), CONICYT FONDECYT: 11180546, 1191003, 11171061, 1190958.