Nomograms of Fetal Cardiac Dimensions at 18-41 Weeks of Gestation
Author
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García Otero, Laura
Author
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Gómez, Olga
Author
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Rodríguez López, Mérida
Author
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Torres, Ximena
Author
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Soveral, Iris
Author
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Sepúlveda Martínez, Álvaro
Author
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Guirado, Laura
Author
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Valenzuela Alcaraz, Brenda
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López, Marta
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Martínez, Josep María
Author
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Gratacos, Eduard
Author
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Crispi, Fátima
Admission date
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2020-07-01T22:32:31Z
Available date
dc.date.available
2020-07-01T22:32:31Z
Publication date
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2020
Cita de ítem
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Fetal Diagnosis and Therapy Volumen: 47 Número: 5 Páginas: 387-398 May 2020
es_ES
Identifier
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10.1159/000494838
Identifier
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https://repositorio.uchile.cl/handle/2250/175735
Abstract
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Objective: There is a need for standardized reference values for cardiac dimensions in prenatal life. The objective of the present study was to construct nomograms for fetal cardiac dimensions using a well-defined echocardiographic methodology in a low-risk population. Methods: This is a prospective cohort study including 602 low-risk singleton pregnancies undergoing a standardized fetal echocardiography to accurately assess fetal cardiac, ventricular, and atrial dimensions. Parametric regressions were tested to model each measurement against gestational age from 18 to 41 weeks of gestation. Results: Nomograms were constructed for fetal cardiac dimensions (transverse and longitudinal diameters and areas) of the whole heart, atria, and ventricles, as well as myocardial wall thicknesses. All dimensions showed a progressive increase with gestational age. The best model for most parameters was a second-degree linear polynomial. Fetal cardiac, ventricular, and atrial diameters and areas were successfully obtained in 98.6% of the fetuses, while myocardial wall thicknesses could be obtained in 96.5% of the population. The results showed excellent interobserver and intraobserver reproducibility (intraclass correlation coefficient, ICC > 0.811 and ICC > 0.957, respectively). Conclusions: We provide standardized and comprehensively evaluated reference values for fetal cardiac morphometric parameters across gestation in a low-risk population. These no mograms would enable the early identification of different patterns of fetal cardiac remodeling.
es_ES
Patrocinador
dc.description.sponsorship
European Union (EU)
2013-0040
La Caixa Foundation
LCF/PR/GN14/10270005
Instituto de Salud Carlos III
PI14/00226
INT16/00168
PI17/00675
PI15/00263
PI15/00130
Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK) AGAUR 2017 SGR grant
1531
Ajut Josep Font (Hospital Clinic de Barcelona, Spain)
Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR)
2016FI_B01184