Show simple item record

Authordc.contributor.authorNoriega Sepúlveda, Viviana Carolina 
Authordc.contributor.authorSierralta García, Fernando 
Authordc.contributor.authorPoblete, P. 
Authordc.contributor.authorAranda, N. 
Authordc.contributor.authorSotomayor Zárate, R 
Authordc.contributor.authorPrieto Domínguez, Juan Carlos 
Authordc.contributor.authorMiranda Guzmán, Hugo 
Admission datedc.date.accessioned2020-10-06T21:56:06Z
Available datedc.date.available2020-10-06T21:56:06Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationJ Biosci (2020) 45:94es_ES
Identifierdc.identifier.other10.1007/s12038-020-00064-z
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/177020
Abstractdc.description.abstractVarious animal models, especially rodents, are used to study pain, due to the difficulty of studying it in humans. Many drugs that produce analgesia have been studied and there is evidence among which NSAIDs deserve to be highlighted. Dexketoprofen (DEX) provides a broad antinociceptive profile in different types of pain; therefore, this study was designed to evaluate the profile of antinociceptive potency in mice. Analgesic activity was evaluated using the acetic acid abdominal constriction test (writhing test), a chemical model of visceral pain. Dose-response curves for i.p. DEX administration (1, 3, 10, 30 and 100 mg/kg), using at least six mice in each of at least five doses, was obtained before and 30 min after pre-treatment with different pharmacological agents. Pretreatment of the mice with opioid receptor antagonists was not effective; however, the serotonin receptor antagonist and nitric oxide synthase inhibitor produce a significant increase in DEX-induced antinociception. The data from the present study shows that DEX produces antinociception in the chemical twisting test of mice, which is explained with difficulty by the simple inhibition of COX. This effect appears to be mediated by other mechanisms in which the contribution of the NO and 5-HT pathways has an important effect on DEX-induced antinociception.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherIndian Academy of Scienceses_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceJournal of Bioscienceses_ES
Keywordsdc.subjectDexketoprofenes_ES
Keywordsdc.subjectReceptor antagonistses_ES
Keywordsdc.subjectViscerales_ES
Keywordsdc.subjectWrithing testes_ES
Títulodc.titleReceptors involved in dexketoprofen analgesia in murine visceral paines_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISI
Indexationuchile.indexArtículo de publicación SCOPUS


Files in this item

Icon

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile