Comportamiento clínico y factores asociados a mortalidad temprana en una cohorte de pacientes chilenos con vasculitis asociadas a anticuerpos anti citoplasma de neutrófilos (VAA)
Author
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Flores Vargas, Daniela
Author
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Goecke Sariego, Annelise
Author
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Gatica Rossi, Héctor
Author
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Castro Lara, Ariel
Author
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Wurmann Kiblisky, Pamela
Admission date
dc.date.accessioned
2021-03-08T21:44:20Z
Available date
dc.date.available
2021-03-08T21:44:20Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Rev Med Chile 2020; 148: 755-761
es_ES
Identifier
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10.4067/S0034-98872020000600755
Identifier
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https://repositorio.uchile.cl/handle/2250/178588
Abstract
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Cumulative survival in patients with anti-neutrophil cytoplasmic
antibodies (ANCA) associated vasculitis (VAA) is 88 and 78% at 1 and 5
years, respectively. Despite this, mortality continues to be 2.7 times higher than
the general population. Differences in the clinical profile of VAA in different
ethnicities have been observed. Aim: To identify factors at the time of diagnosis,
associated with mortality at one year of follow-up and to describe the clinical
characteristics of these patients. Material and Methods: We identified in local
databases and reviewed clinical records of patients with VAA with at least one
year of follow up in a clinical hospital. Demographic and laboratory parameters
and clinical activity scores were analyzed. Results: Of 103 patients with VAA
identified, 65 met the inclusion criteria and were analyzed. Their age ranged
from 45 to 63 years and 56% were women. Thirty-five patients (54%) were
diagnosed as granulomatosis with Polyangiitis (GPA) and 30 patients (46%)
with Microscopic Polyangiitis (MPA). The frequency of renal disease was 53%
and pulmonary involvement occurred in 72%. At one year of follow-up 11
patients died resulting in a mortality of 17%. Seven patients died within three
months after diagnosis. MPO ANCA were more common than PR3 ANCA. In
the multivariate analysis, the presence of ophthalmological involvement, lung
kidney syndrome and a Five Factor Score (FFS) of 1 or more were independent
factors associated with mortality at one year. Conclusions: In these patients,
pulmonary manifestations predominate. Lung kidney syndrome, ophthalmological
involvement and a FFS score ≥ 1 were associated with mortality.
Comportamiento clínico y factores asociados a mortalidad temprana en una cohorte de pacientes chilenos con vasculitis asociadas a anticuerpos anti citoplasma de neutrófilos (VAA)
es_ES
Title in another language
dc.title.alternative
Variables associated with mortality in 103 patients with anti-neutrophil cytoplasmic antibodies associated vasculitis