Equine-like H3 avian influenza viruses in wild birds, Chile
Author
dc.contributor.author
Bravo Vásquez, Nicolás
Author
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Yao, Jiangwei
Author
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Jiménez Bluhm, Pedro
Author
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Meliopoulos, Victoria
Author
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Freiden, Pamela
Author
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Sharp, Bridgett
Author
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Estrada, Leonardo
Author
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Davis, Amy
Author
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Cherry, Sean
Author
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Livingston, Brandi
Author
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Danner, Angela
Author
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Schultz Cherry, Stacey
Author
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Hamilton West, Christopher
Admission date
dc.date.accessioned
2021-07-13T21:13:07Z
Available date
dc.date.available
2021-07-13T21:13:07Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Emerging Infectious Diseases Vol. 26, No. 12, December 2020
es_ES
Identifier
dc.identifier.other
10.3201/eid2612.202063
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/180574
Abstract
dc.description.abstract
Since their discovery in the United States in 1963, outbreaks
of infection with equine influenza virus (H3N8)
have been associated with serious respiratory disease
in horses worldwide. Genomic analysis suggests that
equine H3 viruses are of an avian lineage, likely originating
in wild birds. Equine-like internal genes have been
identified in avian influenza viruses isolated from wild
birds in the Southern Cone of South America. However,
an equine-like H3 hemagglutinin has not been identified.
We isolated 6 distinct H3 viruses from wild birds in Chile
that have hemagglutinin, nucleoprotein, nonstructural
protein 1, and polymerase acidic genes with high nucleotide
homology to the 1963 H3N8 equine influenza virus
lineage. Despite the nucleotide similarity, viruses from
Chile were antigenically more closely related to avian
viruses and transmitted effectively in chickens, suggesting
adaptation to the avian host. These studies provide
the initial demonstration that equine-like H3 hemagglutinin
continues to circulate in a wild bird reservoir.
es_ES
Patrocinador
dc.description.sponsorship
United States Department of Health & Human Services
National Institutes of Health (NIH) - USA HHSN272201400006C
American Lebanese Syrian Associated Charities (ALSAC)