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Authordc.contributor.authorSamaniego, Francisco 
Authordc.contributor.authorConte, Guillermo 
Cita de ítemdc.identifier.citationRevista Médica de Chile 2020; 148: 1467-1474es_ES
Abstractdc.description.abstractCoronavirus disease 19 is characterized by an intense inflammatory response and a high incidence of thrombotic events. Autopsy studies show severe endothelial injury associated with thrombosis of the alveolar capillaries of the lungs and other organs. In the pathophysiology of this disease endothelial injury and dysfunction, inflammation and thrombosis are key factors for the development of severe phenotypes. Therefore, we should consider this entity as a systemic endothelial disease in which an obstructive microvascular syndrome secondary to an intense thrombo-inflammatory response leads to acute respiratory insufficiency and multiorgan failure. Heparin is an excellent drug to treat Covid-19 patients due to its anticoagulant, anti-inflammatory, antiviral and endothelial effects. Clinical guidelines agree that the use of heparin thromboprophylaxis is a component of Covid-19 coagulopathy treatment, even though the dose and duration of treatments are not well defined.es_ES
Publisherdc.publisherSociedad Médica de Santiago, Chilees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceRevista Médica de Chilees_ES
Keywordsdc.subjectDisseminated intravascular coagulationes_ES
Keywordsdc.subjectCOVID-19 (Enfermedad)es_ES
Títulodc.titleInfección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoriaes_ES
Title in another languagedc.title.alternativeSARS-CoV-2 infection as a thrombo-inflammatory endothelial diseasees_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Indexationuchile.indexArtículo de publicación ISIes_ES
Indexationuchile.indexArtículo de publicación SCIELOes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile