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Authordc.contributor.authorMaddaleno, Aldo 
Authordc.contributor.authorMaturana, Matías 
Authordc.contributor.authorPokrant, Ekaterina 
Authordc.contributor.authorSan Martín, Betty 
Authordc.contributor.authorCornejo, Javiera 
Cita de ítemdc.identifier.citationAnimals 2021, 11, 1797.es_ES
Abstractdc.description.abstractAntimicrobials premixes are the presentation of choice to administer drugs simultaneously to groups of animals in intensive husbandry systems that require treatment for pathologies of bacterial origin. Among the premixes available for use in poultry, florfenicol and oxytetracycline are commonly administered via food or water. However, their actual concentration in premixes must meet on-label statements to ensure plasma concentrations reach effective therapeutic levels. Hence, this work was designed for the purpose of verifying whether the concentration of antimicrobial present in five premixes matched their on-label statement. Three oxytetracycline premixes, and two of florfenicol, were analysed using a Xevo TQ-S micro UPLC-MS/MS, and an ABSciex API4000 HPLC-MS/MS, respectively. Analytical methodologies were implemented and validated, showing an R2 0.99 for the calibration curves. Oxytetracycline was detected in these premixes at concentrations exceeding on-label statements by 13.28%, 21.54%, and 29.68%, whereas florfenicol concentrations detected in premixes were 13.06% and 14.75% lower than expected. Consequently, this work shows that the concentration of active ingredients that are present in commercial formulations effectively differ from those stated on premix labels, and it also highlights how unpredictable their range of variability might be. This must be addressed through solid and updated laws that guarantee an effective pharmaceutical product.es_ES
Patrocinadordc.description.sponsorshipLaboratory of Veterinary Pharmacology (FARMAVET) of the Faculty of Veterinary and Animal Sciences from the University of Chilees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Keywordsdc.subjectAntimicrobial premixeses_ES
Títulodc.titleOxytetracycline and florfenicol concentrations in food-additive premixes authorised for broiler chickens: assessing degree of agreement with manufacturers labellinges_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile