Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
Author
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Frías Oyarzún, Alondra
Author
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Segura Hidalgo, Paula
Author
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Toro Cabrera, Luis
Author
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Elgueta Segura, Leticia
Author
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Torres Díaz, Rubén
Author
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Alvo Abodovsky, Miriam
Admission date
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2021-09-22T16:25:10Z
Available date
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2021-09-22T16:25:10Z
Publication date
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2021
Cita de ítem
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Revista Médica Chile 2021; 149: 7-12
es_ES
Identifier
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0034-9887
Identifier
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https://repositorio.uchile.cl/handle/2250/182060
Abstract
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The discovery of the phospholipase A2 receptor antigen and
its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis
and follow-up of patients with membranous nephropathy (MN). Thus, some
international guidelines recommend not performing renal biopsy in patients with
positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R
Ab in serum and renal tissue samples from Chilean patients with primary MN.
Material and Methods: Twenty-eight patients aged 50 ± 14 years (20 males)
with biopsy-proven primary MN plus a negative workup for secondary causes
were included. Measurements of serum and renal histologic anti-PLA2R Ab
were performed. The relationship between the findings of serum and tissue anti-
PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R
Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in
the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive
antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is
potentially useful in the diagnosis of patients with suspected primary MN in
Chilean population.