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Authordc.contributor.authorFrías Oyarzún, Alondra 
Authordc.contributor.authorSegura Hidalgo, Paula 
Authordc.contributor.authorToro Cabrera, Luis 
Authordc.contributor.authorElgueta Segura, Leticia 
Authordc.contributor.authorTorres Díaz, Rubén 
Authordc.contributor.authorAlvo Abodovsky, Miriam 
Admission datedc.date.accessioned2021-09-22T16:25:10Z
Available datedc.date.available2021-09-22T16:25:10Z
Publication datedc.date.issued2021
Cita de ítemdc.identifier.citationRevista Médica Chile 2021; 149: 7-12es_ES
Identifierdc.identifier.issn0034-9887
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/182060
Abstractdc.description.abstractThe discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. Material and Methods: Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti- PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.es_ES
Lenguagedc.language.isoeses_ES
Publisherdc.publisherSociedad Médica de Santiago, Chilees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceRevista Médica Chilees_ES
Keywordsdc.subjectGlomerulonephritises_ES
Keywordsdc.subjectMembranouses_ES
Keywordsdc.subjectImmunohistochemistryes_ES
Keywordsdc.subjectImmunoglobulin Ges_ES
Keywordsdc.subjectReceptors, phospholipase A2es_ES
Títulodc.titlePrevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitarioes_ES
Title in another languagedc.title.alternativePhospholipase A2 receptor antigen antibodies in serum and renal biopsies of patients with membranous nephropathyes_ES
Document typedc.typeArtículo de revistaes_ES
Catalogueruchile.catalogadorcfres_ES
Indexationuchile.indexArtículo de publicación ISIes_ES
Indexationuchile.indexArtículo de publicación SCIELOes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile