Validation of 4D flow based relative pressure maps in aortic flows
Author
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Nolte, David Julian
Author
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Urbina, Jesus
Author
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Sotelo, Julio
Author
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Sok, Leo
Author
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Montalba, Cristian
Author
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Valverde, Israel
Author
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Osses, Axel
Author
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Uribe, Sergio
Author
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Bertoglio Beltrán, Cristóbal Andrés
Admission date
dc.date.accessioned
2022-01-10T14:06:20Z
Available date
dc.date.available
2022-01-10T14:06:20Z
Publication date
dc.date.issued
2021
Cita de ítem
dc.identifier.citation
Medical Image Analysis 74 (2021) 102195
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Identifier
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10.1016/j.media.2021.102195
Identifier
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https://repositorio.uchile.cl/handle/2250/183582
Abstract
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While the clinical gold standard for pressure difference measurements is invasive catheterization, 4D Flow MRI is a promising tool for enabling a non-invasive quantification, by linking highly spatially resolved ve- locity measurements with pressure differences via the incompressible Navier–Stokes equations. In this work we provide a validation and comparison with phantom and clinical patient data of pressure differ- ence maps estimators. We compare the classical Pressure Poisson Estimator (PPE) and the new Stokes Estimator (STE) against catheter pressure measurements under a variety of stenosis severities and flow intensities. Specifically, we use several 4D Flow data sets of realistic aortic phantoms with different anatomic and hemodynamic severities and two patients with aortic coarctation. The phantom data sets are enriched by subsampling to lower resolutions, modification of the segmentation and addition of synthetic noise, in order to study the sensitivity of the pressure difference estimators to these factors. Overall, the STE method yields more accurate results than the PPE method compared to catheterization data. The superiority of the STE becomes more evident at increasing Reynolds numbers with a better capacity of capturing pressure gradients in strongly convective flow regimes. The results indicate an im- proved robustness of the STE method with respect to variation in lumen segmentation. However, with heuristic removal of the wall-voxels, the PPE can reach a comparable accuracy for lower Reynolds’ num- bers.
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Lenguage
dc.language.iso
en
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Publisher
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Elsevier
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Type of license
dc.rights
Attribution-NonCommercial-NoDerivs 3.0 United States