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Authordc.contributor.authorMendizabal, Manuel
Authordc.contributor.authorPiñero, Federico
Authordc.contributor.authorRidruejo, Ezequiel
Authordc.contributor.authorAnders, Margarita
Authordc.contributor.authorSilveyra, María Dolores
Authordc.contributor.authorTorre, Aldo
Authordc.contributor.authorMontes, Pedro
Authordc.contributor.authorUrzúa Manchego, Álvaro Miguel
Authordc.contributor.authorPages, Josefina
Authordc.contributor.authorToro, Luis G.
Authordc.contributor.authorDíaz, Javier
Authordc.contributor.authorGonzález Ballerga, Esteban
Authordc.contributor.authorMiranda Zazueta, Godolfino
Authordc.contributor.authorGutiérrez, Isabel
Authordc.contributor.authorMichelato, Douglas
Authordc.contributor.authorVenturelli, María Grazia
Authordc.contributor.authorVarón, Adriana
Authordc.contributor.authorVera Pozo, Emilia
Authordc.contributor.authorTagle, Martín
Authordc.contributor.authorGarcía, Matías
Authordc.contributor.authorTassara, Alfredo
Authordc.contributor.authorBrutti, Julia
Authordc.contributor.authorRuiz García, Sandro
Authordc.contributor.authorBustios, Carla
Authordc.contributor.authorEscajadillo, Nataly
Authordc.contributor.authorMacias, Yuridia
Authordc.contributor.authorHiguera De la Tijera, Fátima
Authordc.contributor.authorGómez, Andrés J.
Authordc.contributor.authorDomínguez, Alejandra
Authordc.contributor.authorCastillo Barradas, Mauricio
Authordc.contributor.authorContreras, Fernando
Authordc.contributor.authorScarpin, Aldana
Authordc.contributor.authorSchinoni, María Isabel
Authordc.contributor.authorToledo, Claudio
Authordc.contributor.authorGirala, Marcos
Authordc.contributor.authorMainardi, Victoria
Authordc.contributor.authorSánchez, Abel
Authordc.contributor.authorBessone, Fernando
Authordc.contributor.authorRubinstein, Fernando
Authordc.contributor.authorSilva, Marcelo O.
Admission datedc.date.accessioned2022-03-31T19:53:38Z
Available datedc.date.available2022-03-31T19:53:38Z
Publication datedc.date.issued2021
Cita de ítemdc.identifier.citationAnnals of Hepatology 21 (2021) 100298es_ES
Identifierdc.identifier.other10.1016/j.aohep.2020.100298
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/184638
Abstractdc.description.abstractIntroduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patientswith COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnor-mal liver tests on admission of hospitalized patients with COVID-19.Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients withconfirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from11 Latin American countries. We registered clinical and laboratory parameters, including liver functiontests, on admission and during hospitalization. All patients were followed until discharge or death. Wefit multivariable logistic regression models, further post-estimation effect through margins and inverseprobability weighting.Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liverdisease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7)of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormalliver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normalliver biochemistries 12.2% (CI 10.1–14.6); P < .0001). After excluding patients with history of chronicliver disease, abnormal liver tests on admission were independently associated with death [OR 1.5 (CI1.1–2.0); P = 0.01], and severe COVID-19 (2.6 [2.0–3.3], P < .0001), both adjusted by age, gender, diabetes,pneumonia and body mass index >30.Conclusions: The presence of abnormal liver tests on admission is independently associated with mortalityand severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogatemarker of inflammation.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceAnnals of Hepatologyes_ES
Keywordsdc.subjectSARS-CoV-2es_ES
Keywordsdc.subjectDeathes_ES
Keywordsdc.subjectPandemices_ES
Keywordsdc.subjectHepatitises_ES
Keywordsdc.subjectCoronaviruses_ES
Títulodc.titleProspective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admissiones_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorcfres_ES
Indexationuchile.indexArtículo de publícación WoSes_ES
Indexationuchile.indexArtículo de publicación SCOPUSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States