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Autordc.contributor.authorTapia, David
Autordc.contributor.authorKuznar, Juan
Autordc.contributor.authorFarlora, Rodolfo
Autordc.contributor.authorYáñez López, José Manuel
Fecha ingresodc.date.accessioned2022-12-05T21:12:22Z
Fecha disponibledc.date.available2022-12-05T21:12:22Z
Fecha de publicacióndc.date.issued2022
Cita de ítemdc.identifier.citationViruses 2022, 14, 21es_ES
Identificadordc.identifier.other10.3390/v14010021
Identificadordc.identifier.urihttps://repositorio.uchile.cl/handle/2250/189613
Resumendc.description.abstractThe IPN virus (IPNV) causes a highly contagious disease that affects farmed salmonids. IPNV isolates have been phylogenetically classified into seven genogroups, of which two are present in Chile, genogroups 1 and 5. This study aimed to compare the transcriptomic response of rainbow trout fry challenged with two Chilean isolates of IPNV, RTTX (genogroup 1), and ALKA (genogroup 5). Tissue samples from challenged individuals and controls were taken at 1, 7, and 20 days post-challenge and analyzed by RNA-Seq. The results revealed that infection with RTTX elicited a greater modulation of the trout transcriptome compared to ALKA infection, generating a greater number of highly differentially expressed genes in relation to the control fish. Gene Ontology enrichment indicated that functions related to the inflammatory and immune responses were modulated in fish challenged with both isolates throughout the trial, but with different regulation patterns. On day 1 post challenge, these functions were activated in those challenged with ALKA, but suppressed in RTTX-challenged fish. These results suggest that rainbow trout exhibit a differential transcriptomic response to infection with the two genetically distinct IPNV isolates, especially at early times post-infection.es_ES
Idiomadc.language.isoenes_ES
Publicadordc.publisherMDPIes_ES
Tipo de licenciadc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link a Licenciadc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Fuentedc.sourceViruseses_ES
Palabras clavesdc.subjectIPNVes_ES
Palabras clavesdc.subjectRainbow troutes_ES
Palabras clavesdc.subjectTranscriptomees_ES
Palabras clavesdc.subjectRNA-Seqes_ES
Títulodc.titleDifferential transcriptomic response of rainbow trout to infection with two strains of IPNVes_ES
Tipo de documentodc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogadoruchile.catalogadorapces_ES
Indizaciónuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Excepto si se señala otra cosa, la licencia del ítem se describe como Attribution-NonCommercial-NoDerivs 3.0 United States