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Differential transcriptomic response of rainbow trout to infection with two strains of IPNV
Autor | dc.contributor.author | Tapia, David | |
Autor | dc.contributor.author | Kuznar, Juan | |
Autor | dc.contributor.author | Farlora, Rodolfo | |
Autor | dc.contributor.author | Yáñez López, José Manuel | |
Fecha ingreso | dc.date.accessioned | 2022-12-05T21:12:22Z | |
Fecha disponible | dc.date.available | 2022-12-05T21:12:22Z | |
Fecha de publicación | dc.date.issued | 2022 | |
Cita de ítem | dc.identifier.citation | Viruses 2022, 14, 21 | es_ES |
Identificador | dc.identifier.other | 10.3390/v14010021 | |
Identificador | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/189613 | |
Resumen | dc.description.abstract | The IPN virus (IPNV) causes a highly contagious disease that affects farmed salmonids. IPNV isolates have been phylogenetically classified into seven genogroups, of which two are present in Chile, genogroups 1 and 5. This study aimed to compare the transcriptomic response of rainbow trout fry challenged with two Chilean isolates of IPNV, RTTX (genogroup 1), and ALKA (genogroup 5). Tissue samples from challenged individuals and controls were taken at 1, 7, and 20 days post-challenge and analyzed by RNA-Seq. The results revealed that infection with RTTX elicited a greater modulation of the trout transcriptome compared to ALKA infection, generating a greater number of highly differentially expressed genes in relation to the control fish. Gene Ontology enrichment indicated that functions related to the inflammatory and immune responses were modulated in fish challenged with both isolates throughout the trial, but with different regulation patterns. On day 1 post challenge, these functions were activated in those challenged with ALKA, but suppressed in RTTX-challenged fish. These results suggest that rainbow trout exhibit a differential transcriptomic response to infection with the two genetically distinct IPNV isolates, especially at early times post-infection. | es_ES |
Idioma | dc.language.iso | en | es_ES |
Publicador | dc.publisher | MDPI | es_ES |
Tipo de licencia | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link a Licencia | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Fuente | dc.source | Viruses | es_ES |
Palabras claves | dc.subject | IPNV | es_ES |
Palabras claves | dc.subject | Rainbow trout | es_ES |
Palabras claves | dc.subject | Transcriptome | es_ES |
Palabras claves | dc.subject | RNA-Seq | es_ES |
Título | dc.title | Differential transcriptomic response of rainbow trout to infection with two strains of IPNV | es_ES |
Tipo de documento | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Catalogador | uchile.catalogador | apc | es_ES |
Indización | uchile.index | Artículo de publícación WoS | es_ES |
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