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Authordc.contributor.authorFoncea, Patricio
Authordc.contributor.authorMondschein Prieto, Susana Verónica
Authordc.contributor.authorOlivares Acuña, Marcelo Osvaldo
Admission datedc.date.accessioned2023-07-21T21:04:49Z
Available datedc.date.available2023-07-21T21:04:49Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationScientifc Reports (2022) 12:3620es_ES
Identifierdc.identifier.other10.1038/s41598-022-07447-2
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/194932
Abstractdc.description.abstractThe quarantine of identified close contacts has been vital to reducing transmission rates and averting secondary infection risk before symptom onset and by asymptomatic cases. The effectiveness of this contact tracing strategy to mitigate transmission is sensitive to the adherence to quarantines, which may be lower for longer quarantine periods or in vaccinated populations (where perceptions of risk are reduced). This study develops a simulation model to evaluate contact tracing strategies based on the sequential testing of identified contacts after exposure as an alternative to quarantines, in which contacts are isolated only after confirmation by a positive test. The analysis considers different number and types of tests (PCR and lateral flow antigen tests (LFA)) to identify the cost-effective testing policies that minimize the expected infecting days post-exposure considering different levels of testing capacity. This analysis suggests that even a limited number of tests can be effective at reducing secondary infection risk: two LFA tests (with optimal timing) avert infectiousness at a level that is comparable to 14-day quarantine with 80-90% adherence, or equivalently, 7-9 day quarantine with full adherence (depending on the sensitivity of the LFA test). Adding a third test (PCR or LFA) reaches the efficiency of a 14-day quarantine with 90-100% adherence. These results are robust to the exposure dates of the contact, test sensitivity of LFA and alternative models of viral load evolution, which suggests that simple testing rules can be effective for improving contact tracing in settings where strict quarantine adherence is difficult to implement.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherNaturees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceScientifc Reportses_ES
Keywordsdc.subjectSchoolses_ES
Keywordsdc.subjectCOVID-19 (Enfermedad)es_ES
Títulodc.titleReplacing quarantine of COVID-19 contacts with periodic testing is also effective in mitigating the risk of transmissiones_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States