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Authordc.contributor.authorBergmann, Cristian A.
Authordc.contributor.authorBeltrán, Sebastián
Authordc.contributor.authorVega Letter, Ana María
Authordc.contributor.authorMurgas, Paola
Authordc.contributor.authorHernández, María Fernanda
Authordc.contributor.authorGómez, Laura
Authordc.contributor.authorLabrador, Luis
Authordc.contributor.authorCortés, Bastián I.
Authordc.contributor.authorPoblete, Cristian
Authordc.contributor.authorQuijada Cruz, Cristóbal Emilio
Authordc.contributor.authorCarrión, Flavio
Authordc.contributor.authorWoehlbier, Ute
Authordc.contributor.authorManque, Patricio A.
Cita de ítemdc.identifier.citationCells 2022, 11, 1503es_ES
Abstractdc.description.abstractMesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using dextran sulfate sodium (DSS)-induced colitis. Recently, the modulation of autophagy in MSC has been suggested as a novel strategy to improve MSC-based immunotherapy. Hence, we investigated a possible role of Pacer, a novel autophagy enhancer, in regulating the immunosuppressive function of MSC in the context of DSS-induced colitis. We found that Pacer is upregulated upon stimulation with the pro-inflammatory cytokine TNF alpha, the main cytokine released in the inflammatory environment of IBD. By modulating Pacer expression in MSC, we found that Pacer plays an important role in regulating the autophagy pathway in this cell type in response to TNF alpha stimulation, as well as in regulating the immunosuppressive ability of MSC toward T-cell proliferation. Furthermore, increased expression of Pacer in MSC enhanced their ability to ameliorate the symptoms of DSS-induced colitis in mice. Our results support previous findings that autophagy regulates the therapeutic potential of MSC and suggest that the augmentation of autophagic capacity in MSC by increasing Pacer levels may have therapeutic implications for IBD.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT PIA/ANILLOS ACT1109 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1150743 1200459 Fondo Puente PEP-I-2019054 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11190258es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Keywordsdc.subjectInflammatory bowel diseasees_ES
Keywordsdc.subjectMesenchymal stem cellses_ES
Títulodc.titleThe autophagy protein pacer positively regulates the therapeutic potential of mesenchymal stem cells in a mouse model of DSS-induced colitises_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States