Repositorio Académico de la Universidad de Chile: Recent submissions

Now showing items 39701-39720 of 98886

    • Novel pathogenic mechanism suggested by ex vivo analysis of MCT8 (SLC16A2) mutations 
      Visser, W. Edward; Jansen, Jurgen; Friesema, Edith C.H.; Kester, Monique H.A.; Mancilla, Edna; Lundgren, Johan; Van Der Knaap, Marjo S.; Lunsing, Roelineke J.; Brouwer, Oebele F.; Visser, Theo J. (2009)
      Monocarboxylate transporter 8 (MCT8; approved symbol SLC16A2) facilitates cellular uptake and efflux of 3,3′,5-triiodothyronine (T3). Mutations in MCT8 are associated with severe psychomotor retardation, high serum T3 and ...
    • Peptides conjugated to gold nanoparticles induce macrophage activation 
      Bastús, Neus G.; Sánchez-Tilló, Ester; Pujals, Silvia; Farrera, Consol; Kogan Bocian, Marcelo; Giralt, Ernest; Celada, Antonio; Lloberas, Jorge; Puntes, Victor (2009)
      Macrophages that react against pathogenic organisms can also be activated with artificial nanometric units consisting of gold nanoparticles (Au NPs) with a peptide coating. Using bone marrow-derived macrophages, here we ...
    • E180splice mutation in the growth hormone receptor gene in a Chilean family with growth hormone insensitivity: ... 
      Espinosa, Claudia; Sjoberg, Marcela; Salazar, Teresa; Rodriguez, Adrian; Cassorla Goluboff, Fernando; Mericq, Verónica; Carvallo, Pilar (Freund Publishing House Ltd, 2008)
      Mutations in the GH receptor gene have been identified as the cause of growth hormone insensitivity syndrome (GHIS), a rare autosomal recessive disorder. We studied the clinical and biochemical characteristics and the ...
    • Tumor necrosis factor-α-stimulated membrane type 1-matrix metalloproteinase production is modulated by ... 
      Smith, P.C.; Guerrero, J.; Tobar, N.; Cáceres, M.; González, M. J.; Martínez, J. (2009)
      Background and Objectives: Membrane type 1-matrix metalloproteinase (MT1-MMP) is a collagenolytic enzyme involved in connective tissue remodeling. In periodontal tissues, either cytokines or growth factors regulate the ...
    • Laparoscopic repair of renal artery aneurysm: A description of the technique and results in 2 cases 
      Castillo, Octavio A.; Vitagliano, Gonzalo J.; Sanchez-Salas, Rafael; Chamorro, Hernán; Fava, Mario; Díaz, Manuel A. (2008)
      Background and Purpose: Renal artery aneurysm is a rare occurrence. We report our experience in the management of 2 symptomatic renal artery aneurysms with laparoscopic approach. Material and Methods: Two patients, male ...
    • An Fgf8-Dependent Bistable Cell Migratory Event Establishes CNS Asymmetry 
      Regan, Jennifer C.; Concha, Miguel L.; Roussigne, Myriam; Russell, Claire; Wilson, Stephen W. (2009)
      Neuroanatomical and functional asymmetries are universal features of the vertebrate CNS, but how asymmetry is generated is unknown. Here we show that zebrafish fgf8 mutants do not elaborate forebrain asymmetries, demonstrated ...
    • Estrogen and type 1 diabetes mellitus 
      Codner Dujovne, Ethel (2008)
      Patients with type 1 diabetes mellitus (T1DM) face an array of difficulties during puberty which tend to be more significant in females. Excessive weight and fat mass gain, deterioration of metabolic control, loss of height ...
    • Changes in bone mineral density, body composition and adiponectin levels in morbidly obese patients after ... 
      Carrasco, Fernando; Ruz, Manuel; Arenas Rojas, Pamela; Csendes Juhasz, Attila; Rebolledo, Annabella; Codoceo, Juana; Inostroza, Jorge; Basfi-fer Obregón, Karen; Papapietro Vallejo, Karin; Vargas Rojas, Jorge Antonio; Pizarro Aguirre, Fernando; Olivares, Manuel (2009)
      Background: Gastric bypass surgery (GBP) is increasingly used as a treatment option in morbid obesity. Little is known about the effects of this surgery on bone mineral density (BMD) and the underlying mechanisms. To ...
    • Expression and activity of 11β-hydroxysteroid dehydrogenase type 1 enzyme in subcutaneous and visceral ... 
      Mericq, Verónica; Medina, Pablo; Bouwman, Carolien; Johnson, M. Cecilia; Godoy, Jorge; López, Teresa; Iñíguez Vila, Germán (2009)
      Background: Glucocorticoid excess promotes visceral obesity and cardiovascular disease. Ligand availability to the glucocorticoid receptor is controlled by isoforms of 11β-hydroxysteroid dehydrogenase (11β-HSD) which ...
    • Persistent Vesicourethral Anastomotic Leak After Laparoscopic Radical Prostatectomy: Laparoscopic Solution 
      Castillo, Octavio A.; Alston, Celeste; Sanchez-Salas, Rafael (2009)
      Objectives: To describe our experience with laparoscopic reintervention for persistent vesicourethral anastomotic leak (PVAL) after laparoscopic radical prostatectomy (LRP). PVAL after LRP is an unusual complication. ...
    • Reprimo as a potential biomarker for early detection in gastric cancer 
      Bernal, Carolina; Aguayo, Francisco; Villarroel, Cynthia; Vargas, Macarena; Díaz, Ignacio; Ossandon, Francisco J.; Santibáñez, Eudocia; Palma, Mariana; Aravena, Edmundo; Barrientos, Carlos; Corvalan, Alejandro (2008)
      Purpose: Gastric cancer is a curable disease if diagnosed at early stage. However, most cases are diagnosed at advanced stage because of the lack of screening programs. Therefore, the identification of plasma biomarkers ...
    • Pulmonary histoplasmosis Histoplasmosis pulmonar 
      Hernán Cabello, A.; Denise Manieu, M.; Miguel Noriega R, L.; Manuel Meneses, C.; Marcial Peralta, M.; Constanza Larraguibel, H. (2002)
      Histoplasma capsulatum is a dysmorphic fungus that dwells on earth in specific geographic locations. Its presence is favored by the droppings of bird and bats. The human infection is caused by the inhalation of a high ...
    • Thromboprophylaxis in the surgical patient Tromboprofilaxis en el paciente quirúrgico 
      Espinoza, Ana María (2008)
      Venous thromboembolic disease (VTD), manifested as deep venous thrombosis (DVT), pulmonary embolism or both, is a source of morbidity and mortality in patientes undergoing surgery. Pulmonary embolism is the most common ...
    • Insulin resistance markers in children 
      Eyzaguirre, Francisca; Mericq, Verónica (2009)
      The prevalence of obesity among children and adolescents is progressively increasing around the world. One of the important consequences of obesity is the development of insulin resistance (IR). This condition has a ...
    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease 
      Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo, Miguel; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (2008)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in ...
    • Recurrent lumbar disc herniation: Results of surgical treatment in patients entitle to a worker's compensation ... 
      Marré Pacheco, Bartolomé; Zamorano P., Juan José; Ilabaca G., Francisco; González C., Fernando; Melero D., Patricio; Yurca B., Ratko; Munjin L., Milan; Urzúa B., Alejandro; Lecaros L., Miguel Ángel; Ballesteros P., Vicente; Fleiderman V., José (2008)
      Recurrent lumbar disc herniation is the main cause of radicular pain after lumbar discectomy, with a reported incidence between 5 and 12.5%. Objectives: Evaluate the results of surgical treatment for recurrent lumbar disc ...
    • Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation 
      Friesema, Edith C H; Grueters, Prof Annette; Biebermann, Heike; Krude, Heiko; Von Moers, Arpad; Reeser, Maarten; Barrett, Timothy G.; Mancilla, Edna E.; Svensson, Johan; Kester, Monique H A; Kuiper, George G J M; Balkassmi, Sahila; Uitterlinden, André G.; Koehrle, Pro (2004)
      Monocarboxylate transporter 8 (MCT8) is a thyroid hormone transporter, the gene of which is located on the X chromosome. We tested whether mutations in MCT8 cause severe psychomotor retardation and high serum triiodothyronine ...
    • Investigating the neural correlates of continuous speech computation with frequency-tagged neuroelectric responses 
      Buiatti, Marco; Peña, Marcela; Dehaene-Lambertz, Ghislaine (2009)
      In order to learn an oral language, humans have to discover words from a continuous signal. Streams of artificial monotonous speech can be readily segmented based on the statistical analysis of the syllables' distribution. ...
    • Consumption of antidepressants in Chile from 1992 to 2004 Consumo de antidepresivos en Chile entre 1992 y 2004 
      Jrón, Marcela; Machado, Márcio; Ruiz, Inés (2008)
      Background: Data from the Mnistry of Health show that in Chile in 2004, 17% of the population had some form of depresdon and mood disorders are the tenth cause of disability-adjusted life years (DALY) loss. Aim: To determine ...
    • Quality of life in climacteric Chilean women treated with low-dose estrogen 
      Aedo Monsalve, Sócrates; Schiattino, Irene; Cavada Chacón, Gabriel; Porcile, Arnaldo (2008)
      Objectives: To evaluate the impact of low-dose oral estrogen therapy on the health-related quality of life (HRQoL) in 45-64-year-old women from the East Metropolitan Health Service (SSMO) in Santiago, Chile. Material and ...