Repositorio Académico de la Universidad de Chile: Recent submissions

Now showing items 41181-41200 of 101786

    • Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with ... 
      Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina (Elsevier Ltd, 2014)
      Trypanosoma cruzi, the agent of Chagas' disease, the sixth neglected tropical disease worldwide, infects 10-12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes are complement-resistant ...
    • Systemic lupus erythematosus impairs memory cognitive tests not affected by depression 
      Calderón, J.; Flores P., Jorge; Babul, M.; Aguirre, J. M.; Slachevsky Chonchol, Andrea; Padilla, O.; Scoriels, L.; Henríquez, C.; Cárcamo, C.; Bravo-Zehnder, M.; González, A.; Massardo, L. (SAGE Publications Ltd, 2014)
      Objective: Our aim was to assess the contribution of depression to cognitive impairment in patients with systemic lupus erythematosus (SLE). Methods: Clinical features, education, age, and Hospital Anxiety and Depression ...
    • A new method to measure autophagy flux in the nervous system 
      Matus, Soledad; Valenzuela, Vicente; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
    • Searching for novel Cdk5 substrates in brain by comparative phosphoproteomics of wild type and Cdk5-/- mice 
      Contreras Vallejos, Erick; Utreras Puratich, Elías; Bórquez, Daniel A.; Prochazkova, Michaela; Terse, Anita; Jaffe, Howard; Toledo, Andrea; Arruti, Cristina; Pant, Harish C.; Kulkarni, Ashok B.; González Billault, Christian (Public Library of Science, 2014)
      Protein phosphorylation is the most common post-translational modification that regulates several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase which is mostly ...
    • Exercise sensitizes skeletal muscle to extracellular ATP for IL-6 expression in mice 
      Fernández Verdejo, Rodrigo; Casas, M.; Galgani Fuentes, José; Jaimovich Pérez, Enrique; Buvinic Radic, Sonja (Georg Thieme Verlag, 2014)
      Active skeletal muscle synthesizes and releases interleukin-6 (IL-6), which plays important roles in the organism's adaptation to exercise. Autocrine/paracrine ATP signaling has been shown to modulate IL-6 expression. The ...
    • A new rotating-disk sorptive extraction mode, with a copolymer of divinylbenzene and N-vinylpyrrolidone ... 
      Cañas, Alejandro; Valdebenito, Samuel; Richter Duk, Pablo (Springer Verlag, 2014)
      A novel extraction approach was developed based on rotating-disk sorptive extraction (RDSE). In this approach the rotating-disk extraction device consists of a Teflon disk, with a cavity that is loaded with a commercial ...
    • Greater prevalence of Y chromosome Q1a3a haplogroup in Y-microdeleted Chilean men: a case-control study. 
      Lardone, María C.; Marengo, Altinay; Parada Bustamante, Alexis; Cifuentes, Lucía; Piottante, Antonio; Ebensperger, Mauricio; Valdevenito, Raúl; Castro, Andrea (2013)
      To determine the prevalence of South Amerindian Y chromosome in Chilean patients with spermatogenic failure and their association with classical and/or AZFc-partial Y chromosome deletions. We studied 400 men, 218 with ...
    • Endothelial heterogeneity in the umbilico-placental unit: DNA methylation as an innuendo of epigenetic diversity 
      Casanello, Paola; Schneider, Daniela; Herrera, Emilio A.; Uauy Dagach-Imbarack, Ricardo; Krause, Bernardo J. (Frontiers Media SA, 2014)
      The endothelium is a multifunctional heterogeneous tissue playing a key role in the physiology of every organ. To accomplish this role the endothelium presents a phenotypic diversity that is early prompted during vascular ...
    • The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution ... 
      Urrutia, Pamela J.; Mena, Natalia P.; Núñez González, Marco (Frontiers Media SA, 2014)
      A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's ...
    • Irrelevant stimulus processing in ADHD: catecholamine dynamics and attentional networks 
      Aboitiz, Francisco; Ossandón, Tomás; Zamorano, Francisco; Palma, Bárbara; Carrasco, Ximena (Frontiers Media, 2014)
      A cardinal symptom of attention deficit and hyperactivity disorder (ADHD) is a general distractibility where children and adults shift their attentional focus to stimuli that are irrelevant to the ongoing behavior. This ...
    • Children's attachment evolution with the educational staff in chilean child care centers Evolución del ... 
      María Pía Santelices, A.; Francisca Pérez, C. (2013)
      The present study pretends to evaluate the bond that the children develop with their care centre staff in Chilean crèches, analyzing the caregiver sensitivity and the cooperative child response. A group of 43 toddlers ...
    • Pan-American mDNA haplogroups in Chilean patients with Leber's hereditary optic neuropathy 
      Romero, Pablo; Fernández, Verónica; Slabaugh, Mark; Seleme, Nicolás; Reyes, Nury; Gallardo, Patricia; Herrera, Luisa; Peña, Luis; Pezo, Patricio; Moraga, Mauricio (2014)
      Purpose: The clinical impact of mDNA mutations on the development of Leber hereditary optic neuropathy (LHON) may be modulated by mitochondrial haplogroups, which vary across populations. The aim of this research was to ...
    • A review of the non-bulimulid terrestrial mollusca from the Region of Atacama, northern Chile 
      Araya, Juan Francisco; Catalán, Ricardo (Pensoft Publishers, 2014)
      Terrestrial mollusca are sparsely studied in Chile and, for the first time, a formal record of the diversity of land snails in northern Chile is reported. Coastal and desertic areas in the Region of Atacama, in the border ...
    • Preablative serum thyroglobulin as predictor of disease-free survival in differentiated thyroid cancer ... 
      Díaz, René E.; Véliz, Jesús; Wohllk, Nelson (Sociedad Medica de Santiago, 2013)
      Background: Serum thyroglobulin (sTg) is an excellent marker of persistence or recurrence of disease in differentiated thyroid cancer (DTC), however its role as prognostic factor has not been fully established. Aim: To ...
    • Structure of excitatory synapses and GABA 
      Herrera-Molin, Rodrigo; Sarto-Jackson, Isabella; Montenegro Venegas, Carolina; Heine, Martin; Smalla, Karl Heinz; Seidenbecher, Constanze I.; Beesley, Philip W.; Gundelfinger, Eckart D.; Montag, Dirk (American Society for Biochemistry and Molecular Biology Inc., 2014)
      Formation, maintenance, and activity of excitatory and inhibitory synapses are essential for neuronal network function. Cell adhesion molecules (CAMs) are crucially involved in these processes. The CAM neuroplastin-65 ...
    • Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the ... 
      Amador, Cristián A.; Barrientos, Víctor; Peña, Juan; Herrada, Andrés A.; González, Magdalena; Valdés, Solange; Carrasco, Loreto; Alzamora, Rodrigo; Figueroa, Fernando; Kalergis, Alexis M.; Michea Acevedo, Luis (Lippincott Williams and Wilkins, 2014)
      Adaptive immune response has been implicated in inflammation and fibrosis as a result of exposure to mineralocorticoids and a high-salt diet. We hypothesized that in mineralocorticoid-salt-induced hypertension, activation ...
    • Contribution of Ca2+ release channels to hippocampal synaptic plasticity and spatial memory: Potential redox ... 
      Paula-Lima, Andrea C.; Adasme, Tatiana; Hidalgo Tapia, María Cecilia (Mary Ann Liebert Inc., 2014)
      Significance: Memory is an essential human cognitive function. Consequently, to unravel the cellular and molecular mechanisms responsible for the synaptic plasticity events underlying memory formation, storage and loss ...
    • Pediatric liver transplant outcome using severe hypernatremic donors 
      Uribe,; Alba,; González,; Hunter,; Heine,; Íñiguez,; Cavallieri,; Flores,; Soto,; Auad,; Zuleta,; Acuña, (2013)
      Introduction Pediatric liver transplantation is limited by donation. In the last 5 years, urgent conditions have forced transplant teams to accept donors with minor suboptimal conditions, termed "extended donor criteria." ...
    • Arguments connecting social sciences and philosophy 
      Osorio, Francisco (Inst. fur Klinische Psychologie und Gemeindepsychologie, 2014)
      In an interview with Francisco OSORIO, Ian JARVIE talks about social sciences and philosophy in his role as an editor of the journal Philosophy of the Social Sciences. The conversation between JARVIE and OSORIO explores ...
    • Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage 
      Rodrigo Salinas, Ramón; Libuy, Matías; Feliú, Felipe; Hasson, Daniel (Hindawi Limited, 2013)
      Cardiovascular diseases are a leading cause of mortality and morbidity worldwide, with hypertension being a major risk factor. Numerous studies support the contribution of reactive oxygen and nitrogen species in the ...