Now showing items 41961-41980 of 101786

    • Bravo, Denisse; Blondel, Carlos J.; Hoare, Anilei; Leyton Campos, Lisette; Valvano, Miguel A.; Contreras, Inés (2011)
      The cystic fibrosis transmembrane conductance regulator (CFTR) has been proposed as an epithelial cell receptor for the entry of Salmonella Typhi but not Salmonella Typhimurium. The bacterial ligand recognized by CFTR is ...
    • Fookes, Maria; Schroeder, Gunnar N.; Langridge, Gemma C.; Blondel, Carlos J.; Mammina, Caterina; Connor, Thomas R.; Seth-Smith, Helena; Vernikos, Georgios S.; Robinson, Keith S.; Sanders, Mandy; Petty, Nicola K.; Kingsley, Robert A.; Bäumler, Andreas J.; Nuccio, Sean (2011)
      The genus Salmonella contains two species, S. bongori and S. enterica. Compared to the well-studied S. enterica there is a marked lack of information regarding the genetic makeup and diversity of S. bongori. S. bongori has ...
    • Mata, Ignacio F.; Wilhoite, Greggory J.; Yearout, Dora; Bacon, Justin A.; Cornejo-Olivas, Mario; Mazzetti, Pilar; Marca, Victoria; Ortega, Olimpio; Acosta, Oscar; Cosentino, Carlos; Torres, Luis; Medina, Angel C.; Pérez Pastene, Carolina; Díaz Grez, Fernando; Vilariño- (2011)
      Mutations in the LRRK2 gene are the most common genetic cause of Parkinson's disease, with frequencies displaying a high degree of population-specificity. Although more than 100 coding substitutions have been identified, ...
    • Del Canto, Felipe; Valenzuela, Patricio; Cantero, Lidia; Bronstein, Jonathan; Blanco, Jesús E.; Blanco, Jorge; Prado Jiménez, Valeria; Levine, Myron; Nataro, James; Sommerfelt, Halvor; Vidal, Roberto (2011)
      Enterotoxigenic Escherichia coli (ETEC) is an important cause of diarrhea. Three adhesins (Tia, TibA, EtpA), an iron acquisition system (Irp1, Irp2, and FyuA), a GTPase (LeoA), and an autotransporter (EatA) are ETEC ...
    • López, Mercedes N.; Pesce Reyes, Bárbara; Kurte, Mónica; Pérez Núñez, Claudio; Segal, Gabriela; Roa, Johanna; Aguillón Gutiérrez, Juan Carlos; Mendoza Naranjo, Ariadna; Gesser, Borbala; Larsen, Christian; Villablanca, Andrea; Choudhury, Aniruddha; Kiessling, Rolf; Salazar Onfray, Flavio (2011)
      We have previously demonstrated that IT9302, a nonameric peptide homologous to the C-terminal domain of human IL-10, mimics several effects of the cytokine including down-regulation of the antigen presentation machinery ...
    • Gatica, Héctor; Aliste, Marta; Guerrero, Julia; Goecke Sariego, Irmgadt (2011)
      Objectives: To test the effect of MTX on the expression of glucocorticoid receptor (GR) α and β isoforms AB, C and D in peripheral blood mononuclear cells (PBMCs) in culture, from newly diagnosed RA patients and to evaluate ...
    • Sotomayor, Karina; Iñíguez Vila, Germán; Ugarte, Francisca; Villarroel, Claudio; López, Patricia; Avila, Alejandra; Codner Dujovne, Ethel; Cassorla Goluboff, Fernando (2011)
      Objective: To evaluate ovarian function, especially ovulation rate, in adolescents with McCune-Albright syndrome (MAS) and a history of peripheral precocious puberty. Design: Prospective cross-sectional study. Setting: ...
    • Becerra, Alvaro; Echeverra, Cesar; Varela, Diego; Sarmiento, Daniela; Armisn, Ricardo; Nuez-Villena, Felipe; Montecinos, Mario; Simon, Felipe (2011)
      Aims Endothelial dysfunction is decisive in the progression of cardiovascular diseases. Lipopolysaccharide (LPS)-induced reactive oxygen species (ROS)-mediated endothelial cell death is a main feature observed in inflammation ...
    • Montero Vega, Adela; González Araya, Electra (2011)
      Conscience objection is described in clinical practice as a professional right, based mainly in freedom of conscience. A bibliographical review of last ten years is carried out to know the real meaning, extent and ...
    • Vargas, Álvaro; Bustos Obregón, Eduardo; Hartley, Ricardo (2011)
      Hypobaric hypoxia is of interest due to an increase of human populations working at high altitude. Testicular damage is related to the physiological response (neoangiogenesis) to increased intrascrotal blood fl ow as ...
    • Silvano, Liliana; Miras, Mirta; Pérez, Adriana; Picotto, Gabriela; De Barboza, Gabriela Díaz; Muñoz, Liliana; Martin, Silvia; Sobrero, Gabriela; Armelini, Pedro; Mericq, Verónica; De Talamoni, Nori Tolosa (Walter de Gruyter GmbH, 2011)
      Clinical, biochemical and genetic analysis related to bone mineral density (BMD) were carried out in children born small for gestational age (SGA) that failed to achieve postnatal catch-up growth (CUG), SGA children that ...
    • Arredondo, Miguel; Espinoza, Alejandra; Pizarro Aguirre, Fernando; Araya, Magdalena (2011)
      Acute and chronic cellular responses to changes in copper availability are not clear when these changes are mild to moderate, as what often occur in human daily life. The aims of the study were to develop an in vitro copper ...
    • Behrens Pellegrino, María Isabel; Silva, Monica; Schmied, Astrid; Salech Morales, Felipe; Manzur, Hachi; Rebolledo, Rolando; Bull Simpfendorfer, Ricardo; Torres, Vicente; Henríquez, Mauricio; Quest, Andrew F. G. (2011)
      Unlike apoptosis, mechanisms leading to necrosis are less well understood. Moreover, changes in necrosis as a function of age have not been studied in human lymphocytes. H 2O 2-induced death of peripheral lymphocytes (56 ...
    • Miranda, Hugo F.; Noriega, Viviana; Olavarria, Loreto; Zepeda, Ramiro J.; Sierralta, Fernando; Prieto, Juan C. (2011)
      Statins, belonging to a well-known drug class used for lowering cholesterol through competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, also have other pleiotropic properties, such as ...
    • Galleano, Mónica; Tapia Opazo, Gladys; Puntarulo, Susana; Varela, Patricia; Videla Cabrera, Luis; Fernández Arancibia, Virginia (Elsevier, 2011)
      Aims: Liver preconditioning against ischemia–reperfusion (IR) injury is a major area of experimental research, in which regulation of gene expression with cytoprotective responses due to transient oxidative stress development ...
    • Morales, Paola; Bustamante, Diego; Espina-Marchant, Pablo; Neira-Peña, Tanya; Gutiérrez-Hernández, Manuel A.; Allende-Castro, Camilo; Rojas Mancilla, Edgardo (2011)
      Perinatal asphyxia occurs still with great incidence whenever delivery is prolonged, despite improvements in perinatal care. After asphyxia, infants can suffer from short- to long-term neurological sequelae, their severity ...
    • Salinas, Dino G.; Reyes, Juan G.; de la Fuente, Milton (2011)
      Biological membranes contain many domains enriched in phospholipid lipids and there is not yet clear explanation about how these domains can control the activity of phospholipid metabolizing enzymes. Here we used the surface ...
    • Reyes Jedlicki, Marcela; Díaz, Erick; Lera Marques, Lydia; Burrows, Raquel (2011)
      Background: In the last decades, a seven to nine fold increase in the prevalence of teenage obesity and overweight has occurred. Aim: To assess energy intake and metabolism in a sample of overweight and obese adolescents. ...
    • Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Castro, Pablo; Verdejo, Hugo; Mellado, Rosemarie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga, Clara; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • Horta, Fabrizzio; Madariaga, Marcia; García, Alejandra; Hartel, Steffen; Smith, Rosita (2011)
      Background: There is an association between aging and an increased number of sperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material and Methods: Sixty two ...