Repositorio Académico de la Universidad de Chile: Recent submissions

Now showing items 42361-42380 of 101786

    • Update on Rotarix™: An oral human rotavirus vaccine 
      O'Ryan Gallardo, Miguel; Linhares, Alexandre C. (2009)
      Worldwide, rotaviruses are the single most important agents of severe gastroenteritis in infants and young children. Globally, it is estimated that every year rotavirus gastroenteritis causes more than 125 million episodes ...
    • Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation ... 
      Tretter, Verena; Revilla-Sanchez, Raquel; Houston, Catriona; Terunuma, Miho; Havekes, Robbert; Florian, Cédrick; Jurd, Rachel; Vithlani, Mansi; Michels, Guido; Couve, Andrés; Sieghart, Werner; Brandon, Nicholas; Abel, Ted; Smart, Trevor G.; Moss, Stephen J. (2009)
      Fast synaptic inhibition in the brain is largely mediated by γ-aminobutyric acid receptors (GABAAR). While the pharmacological manipulation of GABAAR function by therapeutic agents, such as benzodiazepines can have profound ...
    • Evolution of nutritional status in a cohort of school age children Evolución del estado nutricional en una ... 
      Loaiza Miranda, Susana; Taibo, Marcela; Cornejo, Amalia; Atalah Samur, Eduardo (2009)
      Background: Considering the high prevalence of obesity among children attending elementary schools, it is important to know the evolution of body weight when these children reach adolescent. Aim: To analyze the changes in ...
    • Gastric leak after laparoscopic-sleeve gastrectomy for obesity 
      Burgos, Ana Maria; Braghetto Miranda, Italo; Csendes Juhasz, Attila; Maluenda, Fernando; Korn Bruzzone, Owen; Yarmuch, Julio; Gutierrez, Luis (2009)
      Background: One of the most serious complications after laparoscopic sleeve gastrectomy (LSG) is gastric leak. Few publications exist concerning the treatment of gastric leak. We sought to determine by way of a prospective ...
    • XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy 
      Matus, Soledad; Nassif, Melissa; Glimcher, Laurie H.; Hetz Flores, Claudio (Taylor and Francis Inc., 2009)
      Endoplasmic reticulum (ER) stress has been extensively described in many protein misfolding disorders including amyotrophic lateral sclerosis (ALS). Adaptation to ER stress is mediated by the activation of an integrated ...
    • Energy restriction is associated with lower bone mineral density of the tibia and femur in lean but not ... 
      Hawkins, Jaleah; Cifuentes, Mariana; Pleshko, Nancy L.; Ambia-Sobhan, Hasina; Shapses, Sue A. (2010)
      Energy restriction decreases bone mineral density (BMD), and epidemiological studies suggest that the risk of weight loss-induced bone loss is greater in lean than in heavier individuals. Our goal in this study was to ...
    • Enhancement in liver SREBP-1c/PPAR-α ratio and steatosis in obese patients: Correlations with insulin ... 
      Pettinelli, Paulina; Del Pozo, Talía; Araya, Julia; Rodrigo Salinas, Ramón; Araya, A. Verónica; Smok Sahid, Gladys; Csendes Juhasz, Attila; Gutierrez, Luis; Vargas Rojas, Jorge Antonio; Korn Bruzzone, Owen; Maluenda, Fernando; Diaz, Juan C.; Rencoret, Guillermo; Braghetto Miranda, Italo; Castillo, Jaime; Poniachik Teller, Jaime; (2009)
      Sterol receptor element-binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor-α (PPAR-α) mRNA expression was assessed in liver as signaling mechanisms associated with steatosis in obese patients. ...
    • Obesity prevention in preschool and schoolchildren attending public schools from a district of Santiago, ... 
      Kain Berkovic, Juliana; Concha, Fernando; Salazar Rodríguez, Gabriela; Leyton Dinamarca, Bárbara; Rodríguez, María del Pilar; Ceballos, Ximena; Vio del Río, Fernando Tomás (2009)
      Childhood obesity in Chile has been recognized as a public health problem. In 2006, we developed a school-based obesity prevention pilot project to intervene during 5 months preschool and schoolchildren from 1st to 4th ...
    • Dynamics of clinical and environmental Vibrio parahaemolyticus strains during seafood-related summer diarrhea ... 
      García, Katherine; Torres, Rafael; Uribe, Paulina; Hernández, Cristina; Rioseco, M. Luisa; Romero Ormazábal, Jaime; Espejo Torres, Romilio (2009)
      Seafood consumption-related diarrhea became prevalent in Chile when the pandemic strain of Vibrio parahaemolyticus serotype O3:K6 reached a region in the south of Chile (Region de los Lagos) where approximately 80% of the ...
    • Dynamin 2 mutations associated with human diseases impair clathrin-mediated receptor endocytosis 
      Bitoun, Marc; Durieux, Anne Cécile; Prudhon, Bernard; Bevilacqua, Jorge; Herledan, Adrien; Sakanyan, Vehary; Urtizberea, Andoni; Cartier Rovirosa, Luis; Romero, Norma B.; Guicheney, Pascale (2009)
      Dynamin 2 (DNM2) is a large GTPase involved in the release of nascent vesicles during endocytosis and intracellular membrane trafficking. Distinct DNM2 mutations, affecting the middle domain (MD) and the Pleckstrin homology ...
    • Frequency-modulated vocalizations of eupsophus queulensis (Anura: Cycloramphidae) 
      Opazo, Daniel; Velsquez, Nelson; Veloso,; Penna Varela, Mario (2009)
      The advertisment calls of the recently described frog Eupsophus queulensis (Cycloramphidae) are analyzed, based on recordings of seven males. Eupsophus queulensis emits an advertisment call consisting of a harmonic-rich ...
    • Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct 
      Orihuela, Pedro A.; Zuñiga, Lidia M.; Rios, Mariana; Parada-Bustamante, Alexis; Sierralta, Walter D.; Velásquez, Luis A.; Croxatto, Horacio B. (2009)
      Background: Mating changes the mode of action of 17beta-estradiol (E2) to accelerate oviductal egg transport from a nongenomic to a genomic mode, although in both pathways estrogen receptors (ER) are required. This change ...
    • Spred2 inhibits TGF-β1-induced urokinase type plasminogen activator expression, cell motility and epithelial ... 
      Villar, Victor; Kocić, Jelena; Santibanez, Juan F. (2010)
      TGF-β1 is a potent inductor of malignance in cancer cells. TGF-β1 stimulates the expression of extracellular matrix degrading proteases, cell migration and it is also involved in the epithelial-mesenchymal transition (EMT). ...
    • Testosterone-induced downregulation of anti-Mü llerian hormone expression in granulosa cells from small ... 
      Crisosto King, Nicolás; Sir Petermann, Teresa; Greiner, Monika; Maliqueo Yevilao, Manuel; Moreno, Marcela; Aedo, Paola; Lara Peñaloza, Hernán (2009)
      Polycystic ovary syndrome (PCOS) is characterized by the presence of hyperandrogenism and an increased follicular mass probably determined by deregulation of locally produced factors. Anti-Müllerian hormone (AMH) is a ...
    • ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle 
      Buvinic, Sonja; Almarza, Gonzalo; Bustamante, Mario; Casas, Mariana; López, Javiera; Riquelme, Manuel; Sáez, Juan Carlos; Huidobro Toro, Juan Pablo; Jaimovich Pérez, Enrique (2009)
      ATP released from cells is known to activate plasma membrane P2X (ionotropic) or P2Y (metabotropic) receptors. In skeletal muscle cells, depolarizing stimuli induce both a fast calcium signal associated with contraction ...
    • Higher Infant Blood Lead Levels with Longer Duration of Breastfeeding 
      Lozoff, Betsy; Jimenez, Elias; Wolf, Abraham W.; Angelilli, Mary Lu; Zatakia, Jigna; Jacobson, Sandra W.; Kaciroti, Niko; Clark, Katy M.; Tao, Min; Castillo, Marcela; Walter, Tomas; Pino, Paulina (2009)
      Objective: To determine whether longer breastfeeding is associated with higher infant lead concentrations. Study design: Data were analyzed from 3 studies of developmental effects of iron deficiency in infancy: Costa Rica ...
    • Thelarche and nutritional status: An epidemiological study of two ethnic groups Telarquia y estado nutricional: ... 
      Bustos, Patricia; Amigo, Hugo; Muzzo, Santiago; Ossa, Ximena (2009)
      Background: Improvements in environmental conditions may result in an earlier onset of thelarche. However, its onset is not homogeneous among different population groups. Aim: To assess the relationship between nutritional ...
    • Early gallbladder cancer: Is further treatment necessary? 
      Aretxabala, Xabier de; Roa, Iván; Hepp, Juan; Maluenda, Fernando; Mordojovich, Gerardo; Leon, Jorge; Roa, Juan (2009)
      Background and Objectives: The goal of this study was to evaluate a series of patients with early gallbladder cancer, focusing on the selection of treatment and the role of Rokitansky Aschoff sinus infiltration. Methods: ...
    • Collaborative trial of prenatal thyrotropin-releasing hormone and corticosteroids for prevention of respiratory ... 
      Torres,; Salinas Salinas, Paulina; Maturana, Daniel; Rubio Rubio, Arelys; Gonzalez,; Cox,; Biotti,; D'Apremont,; Gonzales,; Rubio Rubio, Arelys; Rios, Marco; Balboa,; Sfeir,; Roman,; Echeverria, V.; Herrmann,; Llanos, Adolfo; Morgado, Eduardo; Moya, (Mosby Inc., 1998)
      OBJECTIVE: Our purpose was to determine whether adding antenatal thyrotropin-releasing hormone to prenatal corticosteroids reduces the frequency of respiratory distress syndrome. STUDY DESIGN: A randomized, multicenter, ...
    • Prolonged prone position ventilation for severe respiratory distress syndrome post-pneumonectomy. Report ... 
      Cornejo, Rodrigo; Romero, Carlos; Goñi, Daniela; Luengas, Rafael; Llanos, Osvaldo; Gálvez, Ricardo; Castro, José (2009)
      Management of patients with severe respiratory failure is mainly supportive, and protective mechanical ventilation is the pivotal treatment. When conventional therapy is insufficient to improve oxygenation without deleterious ...