Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

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    • Development of an ingredient containing apple peel, as a source of polyphenols and dietary fiber 
      Henríquez, Carolina; Speisky Cosoy, Hernán; Chiffelle, Italo; Valenzuela, Tania; Araya, Manuel; Simpson, Ricardo; Almonacid, Sergio (2010)
      Apple peel is a waste product from dried apple manufacture. The content of phenolic compounds, dietary fiber, and mineral are higher in apple peel, compared to other edible parts of this fruits. The objective of this study ...
    • Redox-active complexes formed during the interaction between glutathione and mercury and/or copper ions 
      Aliaga, Margarita E.; López Alarcón, Camilo; Barriga, Germán; Olea Azar, Claudio; Speisky Cosoy, Hernán (2010)
      Prompted by the recently reported capacity of the physiologically occurring Cu(I)-[glutathione]2 complex (Cu(I)-[GSH)]2) to reduce oxygen, the effect of various GSH-binding metals (Co2+, Cd2+, Zn2+, Pb2+, Al3+, Hg2+ and ...
    • ESR, electrochemical and ORAC studies of nitro compounds with potential antiprotozoal activity 
      Aravena, María C.; Figueroa, Roberto; Olea Azar, Claudio; Arán, Vicente J. (2010)
      Cyclic Voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process ...
    • Voltammetric behavior of naratriptan and its determination in tablets 
      Velasco Aguirre, Carolina; Álvarez Lueje, Alejandro (Elsevier B.V., 2010)
      The electrochemical behavior and the analytical application of the selective serotonin agonist naratriptan (N-methyl-3-(1-methyl-4-piperidyl)indole-5-ethanesulfonamide) are presented herein. Naratriptan exhibits an anodic ...
    • Electrochemistry of interaction of 2-(2-nitrophenyl)-benzimidazole derivatives with DNA 
      Catalán, Mabel; Álvarez Lueje, Alejandro; Bollo Dragnic, Soledad (2010)
      In this study the interaction between new benzimidazole molecules, 2-(2-nitrophenyl)-1H-benzimidazole (NB) and N-benzoyl-2-(2-nitrophenyl)-benzimidazole (BNB), with dsDNA and ssDNA was assessed at pH 7.4. Using differential ...
    • Evaluation of the antioxidant properties and effects on the biotransformation of commercial herbal preparations ... 
      Letelier, María Eugenia; Cortes, Juan; Lepe, Ana; Jara, José; Molina Berríos, Alfredo; Rodriguez, Carmen; Iturra-Montecinos, Pablo; Faúndez, Mario (2009)
      The antioxidant herbal ingredients are xenobiotics for animals, many of them must be biotransformed to be eliminated, especially lipophilic compounds. Biotransformation of such xenobiotics- occurs mainly in the hepatic ...
    • Magnetic manganese dioxide as an amphoteric adsorbent for removal of harmful inorganic contaminants from water 
      Calderon Rosas, Carla; Franzreb, Matthias; Valenzuela, Fernando; Höll, Wolfgang (2010)
      Manganese dioxide (δ-MnO2) with magnetic properties has been synthesized by precipitation of MnO2 in the presence of magnetite. The resulting material has a particle size distribution between 0.5 and 5 μm. Magnetization ...
    • Acute and subchronic toxicological study of senna in rodents Toxicología aguda y subcrónica de una pasta ... 
      Hancke, Juan; Cáceres, Dante; Burgos, Rafael A.; Hernández, Doris; Rojas, Armando; Morales, Miguel A. (2009)
      Senna crude herbal paste, CIRUELAX®, laxative used in America and Spain, was administered by oral gavage to mice and rats once daily in doses from 2 to 10 g/kg for 7 days. LD50 was rated as higher than 10 g/kg. To determine ...
    • Spectroscopic characterization of the inclusion complexes of luteolin with native and derivatized β-cyclodextrin 
      Jullian Matthaei, Carolina; Cifuentes, Constanza; Alfaro, Muriel; Miranda, Sebastián; Barriga, Germán; Olea Azar, Claudio (2010)
      The inclusion complexes of Luteolin (LU) with cyclodextrins (CDs) including β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and dimethyl-β-cyclodextrin (DMβCD), Scheme 1, have been investigated using the method ...
    • Multifunctionalized gold nanoparticles with peptides targeted to gastrin-releasing peptide receptor of a ... 
      Hosta-Rigau, Leticia; Olmedo, Ivonne; Arbiol, Jordi; Cruz, Luis J.; Kogan Bocian, Marcelo; Albericio, Fernando (2010)
      Functionalization of gold nanoparticles (AuNPs) with both a targeting peptide (an analogue of the peptide Bombesin) and a drug peptide ligand (an analogue of the RAF peptide) with the aim of improving selectivity in the ...
    • Contraction-related stimuli regulate GLUT4 traffic in C2C 12-GLUT4myc skeletal muscle cells 
      Niu, Wenyan; Bilan, Philip J.; Ishikura, Shuhei; Schertzer, Jonathan D.; Contreras Ferrat, Ariel Eduardo; Fu, Zhengxiang; Liu, Jie; Boguslavsky, Shlomit; Foley, Kevin P.; Liu, Zhi; Li, Jinru; Chu, Guilan; Panakkezhum, Thomas; Lopaschuk, Gary D.; Lavandero González, Sergio; Yao, Zhi; Klip (2010)
      Muscle contraction stimulates glucose uptake acutely to increase energy supply, but suitable cellular models that faithfully reproduce this complex phenomenon are lacking. To this end, we have developed a cellular model ...
    • Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro 
      Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)
      Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
    • Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured ... 
      Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Improvement of galangin solubility using native and derivative cyclodextrins. An UV-Vis and NMR study 
      Jullian Matthaei, Carolina (2009)
      The slightly water-soluble flavonoid galangin (G) and its inclusion with either β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) or Heptakis-2,6-O-di methyl-β-cyclodextrin (DMβCD) were investigated. The stoichiometric ...
    • Revision and phylogenetics of the genus Paraulax Kieffer (Hymenoptera, Cynipidae) with biological notes and ... 
      Nieves-Aldrey, José Luis; Liljeblad, Johan; Nieves, María Hernández; Grez Villarroel, Audrey; Nylander, Johan A.A. (2009)
      The gall wasp genus Paraulax (Hymenoptera, Cynipidae) associated with southern beeches (Nothofagus (Nothofagaceae)) from South America is revised. The genus Paraulax and its type species, P. perplexa, are redescribed and ...
    • Assessment of extractability of Cu, Cr, Ni, Pb and Zn in some chilean biosolid-amended soils by using BCR ... 
      Ahumada, Inés; Maricán, Adolfo; Retamal, Mauricio; Pedraza, Cristina; Ascar, Loreto; Carrasco, Adriana; Richter Duk, Pablo (Sociedade Brasileira de Quimica, 2010)
      The effect of biosolid application on the distribution and extractability of Cr, Cu, Ni, Pb, and Zn was assessed in Mollisol soils from an important agricultural zone in central Chile. These were amended with biosolids at ...
    • Determination of low molecular weight carbohydrates in Cabernet sauvignon red wines 
      Matsuhiro, Betty; Torres, Rodrigo; Zúñiga, Elisa A.; Aguirre, Maria J.; Mendoza, Leonora; Isaacs, Mauricio (Sociedad Chilena de Quimica, 2009)
      Low molecular weight carbohydrates (LMW) were determined in a Chilean Cabernet Sauvignon red wine by the Dubois method, a specific method for the determination of carbohydrates. Dialysis treatment of red wine allowed the ...
    • Solvent-free microwave-promoted Michael addition of azanucleophiles to benzo[b]thiophen-2-yl-2-propenone 
      Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa Mahana, David; Araya Maturana, Ramiro; Ron, Nadia; Saitz Barría, Claudio (Arkat, 2009)
      A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b]thiophen-2- ...
    • IKK connects autophagy to major stress pathways 
      Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Hélène; Maiuri, Maria Chiara; Morselli, Eugenia; Vitale, Ilio; Kepp, Oliver; Tasdemir, Ezgi; Galluzzi, Lorenzo; Shen, Si; Tailler, Maximilien; Delahaye, Nicolas; Tesniere, Antoine; De Stefano, Daniela; Younes, Aména Ben; Harp (Taylor and Francis Inc., 2010)
      Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both ...
    • Selective interaction of lansoprazole and Astemizole with tau polymers: Potential new clinical use in ... 
      Rojo, Leonel E.; Alzate Morales, Jans; Saavedra, Iván N.; Davies, Peter; Maccioni Baraona, Ricardo (IOS Press, 2010)
      We describe the interactions of two benzimidazole derivatives, astemizole (AST) and lansoprazole (LNS), with anomalous aggregates of tau protein (neurofibrillary tangles). Interestingly, these compounds, with important ...