Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 2181-2200 of 4850

    • Cu(II)–Gd(III) 2D-coordination polymer based on two different organic linkers 
      Cruz, Carlos; Spodine Spiridonova, Evgenia; Venegas Yazigi, Diego; Paredes García, Verónica (Elsevier, 2017)
      A new CuII–GdIII heterometallic coordination polymer was obtained by a two-step synthesis, using the molecular complex [Cu(H2IDC)2(2,20-bipy)] 2H2O (1) as metalloligand and oxalate as auxiliary ligand (H3IDC = ...
    • Gold nanoparticles as an efficient drug delivery system for GLP - 1 peptides 
      Pérez Ortiz, Magdalena; Zapata Urzua, Claudio; Acosta, Gerardo A.; Álvarez Lueje, Alejandro; Albericio, Fernando; Kogan Bocian, Marcelo (Elsevier, 2017)
      In this work, the potential application of gold nanoparticles for GLP-1 analogues delivery was studied. For this purpose, the original sequence of the incretin GLP-1 was slightly modified in the C-terminal region by adding ...
    • Selección de aptámeros de RNA capaces de inhibir a la isoforma Ll2 de la esfingomielinasa D, toxina ... 
      Salinas Luypaert, Catalina Francisca (Universidad de Chile, 2013)
    • Effect of surfactants and drug load on physico mechanical and dissolution properties of nanocrystalline ... 
      Vuddanda, Parameswara Rao; Montenegro Nicolini, Miguel; Morales Montecinos, Javier; Velaga, Sitaram (Elsevier, 2017)
      The aim of the present work was to prepare tadalafil (TDF) nanocrystals-loaded oral polymeric films (OFs) and investigate the effect of hydrophilic surfactants and drug loads on the physico-mechanical and dissolution ...
    • The role of PI3K alpha isoform in cardioprotection 
      Rossello, Xavier; Riquelme, Jaime A.; He, Zhenhe; Taferner, Stasa; Vanhaesebroeck, Bart; Davidson, Sean M.; Yellon, Derek M. (Springer, 2017)
      Ischemic preconditioning (IPC) limits myocardial infarct size through the activation of the PI3K-Akt signal cascade; however, little is known about the roles of individual PI3K isoforms in cardioprotection. We aimed, ...
    • Nitrones: a potential new alternative as therapeutic agents 
      Barriga González, Germán Eduardo; Aliaga, Carolina; Olea Azar, Claudio; Zúniga López, María C.; González, Mercedes; Cerecetto, Hugo (Bentham Science Publishers Ltd., 2017)
      Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
    • Antibacterial activity and human cell cytotoxic of cobalt (III) complexes with 1,10-phenanthroline and ... 
      Parada Aliste, José; Atria Salas, Ana María; Baggio, Ricardo; Wiese, Guillermo; Lagos, Sebastián; Pavon, Alequis; Rivas, Elizabeth; Navarro, Laura; Corsini, Gino (Sociedad Chilena de Química, 2017)
      The mononuclear cobalt (III) complex derived from 1,10-phenanthroline with lactose [Co(phen)(2)lactose]Cl-2 center dot 3H(2)O (1) has been prepared and its properties have been compared with the sucrose complex ...
    • Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles 
      Morales Montecinos, Javier; Brayden, David J. (Elsevier, 2017)
      Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of ...
    • Effect of olive pruning wood extract on lipid oxidation in sunflower oil 
      González Fuentes, Pamela A.; Zúniga López, María C.; Olea Azar, Claudio; Loyola, Cristina; Folch Cano, Christian G. (Pontificia Universidad Católica de Chile, 2017)
      The production of high quality natural Antioxidants from olive pruning wood extracts and their application to prevent the oxidation of vegetable oils were evaluated. The production of antioxidants from branches of olive ...
    • The energy cost of polypeptide knot formation and its folding consequences 
      Bustamante, Andrés; Sotelo Campos, Juan; Guerra, Daniel G.; Floor, Martín; Wilson Moya, Christian; Bustamante, Carlos; Baez, Mauricio (Nature Publishing Group, 2017)
      Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair its folding-and about the effect of a knot on the stability and ...
    • Synthesis and use of nanomagnetic MnO2 adsorbent for removing Pb(II) and Cd(II) ions from acid aqueous solutions 
      Basualto Flores, Carlos; González, Pablo; Briso, Alejandro; Barrera, Kamila; Ide, Viviana; Araya, Mireya; Montes Atenas, Gonzalo; Valenzuela Lozano, Fernando (Desalination Publ, 2017)
      A nanoadsorbent based on delta-MnO2 and Fe3O4 was synthesized and assessed as an adsorbent for removing some heavy metals from acidic aqueous solution. The delta-MnO2 adsorbent was prepared in aqueous alkaline medium using ...
    • Single molecule force spectroscopy reveals the effect of BiP chaperone on protein folding 
      Ramírez, María Paz; Rivera, Maira; Quiroga Roger, Diego; Bustamante Pezoa, Andrés; Vega, Marcela; Baez Larach, Mauricio Andrés; Puchner, Elias M.; Wilson Moya, Christian (Wiley, 2017)
      BiP (Immunoglobulin Binding Protein) is a member of the Hsp70 chaperones that participates in protein folding in the endoplasmic reticulum. The function of BiP relies on cycles of ATP hydrolysis driving the binding and ...
    • The effects of gold nanoparticles functionalized with beta-amyloid specific peptides on an in vitro model ... 
      Ruffa, J.; Hüwelb, S.; Kogan Bocian, Marcelo; Simon, Ulrich; Joachim Gallab, Hans (Elsevier, 2017)
      We studied the effect of gold nanoparticle (AuNP) size, surface charge, concentration and morphology on the integrity of the blood–brain barrier (BBB) in a well-established in vitro model set-up. We focused on the effect ...
    • Metal Nanoparticles for the Treatment and Diagnosis of Neurodegenerative Brain Diseases 
      Vio, Valentina; Marchant, María José; Araya, Eyleen; Kogan Bocian, Marcelo (Bentham Science Publishers Ltd., 2017)
      This review focuses on the application of metal nanoparticles in the diagnosis and treatment of Alzheimer's and Parkinson's diseases. Metal nanoparticles present interesting physicochemical properties that can be applied ...
    • Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate ... 
      Almada, M.; Leal Martínez, B. H.; Hassan, N.; Kogan Bocian, Marcelo; Burboa, M. G.; Topete, A.; Valdez, M. A.; Juarez, J. (Elsevier, 2017)
      Gold nanorods (GNR) use has been proposed in medical applications because of their intrinsic photothermal properties. However, the presence of CTAB molecules adsorbed onto the surface of GNRs results in a highly cytotoxic ...
    • Transfer hydrogenation of N-benzylideneaniline catalyzed by ruthenium complexes with pincer-type phosphorus ... 
      Moya, S. A.; Negrete Vergara, C.; Brown, K.; Artigas, V.; Fuentealba, M.; Guerchais, V.; Aguirre, P. (Elsevier, 2017)
      Ruthenium complexes containing phosphorus-nitrogen, pincer-type (NPN) ligands show high activities and selectivities in the transfer hydrogenation of N-benzylideneaniline using propan-2-ol as the hydrogen source. Such ...
    • Quantum controlled fusion 
      Berrios, Eduardo; Gruebele, Martín; Wolynes, Peter G. (Elsevier, 2017)
      Quantum-controlled motion of nuclei, starting from the nanometer-size ground state of a molecule, can potentially overcome some of the difficulties of thermonuclear fusion by compression of a fuel pellet or in a bulk ...
    • Heterologous expression of an α‑amylase inhibitor from common bean (Phaseolus vulgaris) in Kluyveromyces ... 
      Brain Isasi, Stephanie; Álvarez Lueje, Alejandro; Higgins, Thomas Joseph V. (BioMed Central, 2017-06-15)
      Background: Phaseolamin or alpha-amylase inhibitor 1 (alpha AI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian alpha-amylases. Several clinical studies support the ...
    • Sex hormones and cardiometabolic health: Role of estrogen and estrogen receptors 
      Clegg, Deborah; Hevener, Andrea L.; Moreau, Kerrie L.; Morselli, Eugenia; Criollo Céspedes, Alfredo; Van Pelt, Rachael E.; Vieira Potter, Victoria J. (Oxford University Press, 2017-05)
      With increased life expectancy, women will spend over three decades of life postmenopause. The menopausal transition increases susceptibility to metabolic diseases such as obesity, diabetes, cardiovascular disease, and ...
    • The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic ... 
      García Rojo, Gonzalo; Fresno, Cristóbal; Vilches Peñaloza, Natalia; Díaz Véliz, Emma; Mora Gutiérrez, Sergio; Aguayo Abarca, Felipe; Pacheco Zapata, Aníbal; Parra Fiedler, Nicolás; Parra, Claudio; Rojas Domínguez, Paulina; Tejos Bravo, Macarena; Aliaga, Esteban; Fiedler Temer, Jenny (Oxford University Press, 2017-04-01)
      Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...