Browsing by Author "Cifuentes, Mariana"

Now showing items 1-8 of 8

    • Adipogenic effect of calcium sensing receptor activation 
      Villarroel, Pia; Reyes Jedlicki, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez Winkler, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana (Springer, 2013)
      We established that human adipose cells and the human adipose cell line LS14 express the calciumsensing receptor (CaSR) and that its activation induces inflammatory cytokine production. Also, its expression is enhanced ...
    • Antilipolytic effect of calcimimetics depends on the allelic variant of calcium-sensing receptor gene ... 
      Reyes Jedlicki, Marcela; Rothe, Hansjörg M.; Mattar, Pamela; Shapiro, Warren B.; Cifuentes, Mariana (2012)
      Calcium-sensing receptor polymorphism rs1042636 (Arg990Gly) affects the response to the calcimimetic cinacalcet, used to treat hypercalcemia in secondary hyperparathyroidism (sHPT) or parathyroid carcinoma. Carriers of ...
    • Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and ... 
      Cifuentes, Mariana; Fuentes, Cecilia; Tobar, Nicolás; Acevedo, Ingrid; Villalobos, Elisa; Hugo, Eric; Ben-Jonathan, Nira; Reyes Jedlicki, Marcela (Elsevier, 2012)
      The proinflammatory status of adipose tissue has been linked to the metabolic and cardiovascular consequences of obesity. Human adipose cells express the calcium sensing receptor (CaSR), and its expression is elevated ...
    • Differences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes 
      Cifuentes, Mariana; Albala Brevis, Cecilia; Rojas Baechler, Cecilia (SOC BIOLGIA CHILE, 2008)
      It has been proposed that differences in adipocyte function and/or metabolism between obese and lean individuals may manifest themselves in functional adipose tissue abnormalities that lead to metabolic disorders in obesity. ...
    • Identification of novel 11b-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristóbal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia Castillo, Alejandra; Baudrand, René; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A.; Fardella, Carlos E. (Elsevier, 2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11b-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11b-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Intestinal FABP2 A54T polymorphism: Association with insulin resistance and obesity in women 
      Albala Brevis, Cecilia; Santos, José Luis; Cifuentes, Mariana; Villarroel, Ana C.; Lera Marques, Lydia; Liberman Guendelman, Claudio; Ángel Badillo, Bárbara; Pérez Bravo, Francisco (NORTH AMER ASSOC STUDY OBESITY, 2004-02)
      Objective: To assess the association between the Ala54Thr genetic polymorphism of the fatty acid-binding protein 2 (FABP2) gene with insulin resistance and obesity. Research Methods and Procedures: According to a sampling ...
    • Larger Anti-adipogenic Effect of Angiotensin II on omental preadipose cells of obese humans 
      Brücher, Rodrigo; Cifuentes, Mariana; Acuña, María José; Albala Brevis, Cecilia; Rojas Baechler, Cecilia (NORTH AMER ASSOC STUDY OBESITY, 2007-07)
      Objective: The ability to form new adipose cells is important to adipose tissue physiology; however, the mechanisms controlling the recruitment of adipocyte progenitors are poorly understood. A role for locally generated ...
    • Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression ... 
      Cifuentes, Mariana; Fuentes, Cecilia; Mattar, Pamela; Tobar, Nicolas; Hugo, Eric; Ben-Jonathan, Nira; Rojas Baechler, Cecilia; Martínez, Jorge (2010)
      Obesity-associated health complications are thought to be in part due to the low-grade proinflammatory state that characterizes this disease. The calcium sensing receptor (CaSR), which is expressed in human adipose cells, ...