Now showing items 681-700 of 923

    • Ivanovic Marincovich, Daniza; Leiva, Boris P.; Pérez Muñoz, Hernán; Olivares Grohnert, Manuel; Díaz, Nora S.; Urrutia, María Soledad; Almagiá, Atilio F.; Toro, Triana D.; Miller, Patricio T.; Bosch, Enrique O.; Larraín, Cristián G. (Elsevier, 2004)
      This multifactorial study investigates the interrelationships between head circumference (HC) and intellectual quotient (IQ), learning, nutritional status and brain development in Chilean school-age children graduating ...
    • Ivanovic Marincovich, Daniza; Llop Romero, Elena; Alvear, Jorge A.; Pérez Muñoz, Hernán; Díaz, Nora S.; Leyton Dinamarca, Bárbara; Almagià, Atilio F.; Larraín, Cristián G.; Alvarez, Joel E.; Herrera, Yilda F.; Hazbun, Elizabeth L. (2006-12)
      We describe subject recruitment from the University of Chile School-Age Children Twin Registry (REMEUCHI). The research aim of REMEUCHI is to quantify the impact of genetic and environmental factors on scholastic achievement ...
    • Martínez Winkler, Jorge; Silva, Sofía; Santibáñez, Juan Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1996-04)
      Bone metastasis is a common event and a major cause of morbidity in prostate cancer patients. After colonization of bone, prostate cells induce an osteoblastic reaction which is not associated with marrow fibrosis ...
    • Martínez Winkler, Jorge; Fuentes, Mauricio; Cambiazo Ayala, Liliana; Santibáñez, J. Francisco (WILEY-LISS, DIV JOHN WILEY & SONS INC, 1999-10-08)
      Bone is the most frequent site of metastasis in breast cancer. This causes destructive osteolytic lesions. To achieve metastasis to bone, breast cancer cells must proliferate in a new microenvironment, arrest on ...
    • Guerrero, Javier; Santibáñez, Juan Francisco; González, Alfonso; Martínez Winkler, Jorge (Elsevier Inc., 2004)
      Urokinase-type plasminogen activator receptor (uPAR) and epidermal growth factor receptor (EGFR) are ubiquitous receptors involved in the control of a variety of cellular processes frequently found altered in cancer cells. ...
    • Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar Oliva, Paula; Dotor, Javier; Smith, Patricio C.; Martínez Winkler, Jorge (Springer Science+Business Media, 2011)
      In carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic response. ...
    • Aliaga, Margarita E.; Andrade Acuña, Daniela; López Alarcón, Camilo; Sandoval Acuña, Cristián; Speisky Cosoy, Hernán (Elsevier, 2013)
      Superoxide is a potentially toxic by-product of cellular metabolism.We have addressed here the in vitro ability of complexes formed between copper(II) ions and various biologically-occurring disulfides (RSSR: oxidized ...
    • Muñoz Rojas, María Verónica; Bay, Luisa; Sanchez, Luz; van Kuijck, Marcel; Ospina, Sandra; Cabello, Juan Francisco; Martins, Ana María (2011)
      Background Mucopolysaccharidosis I (MPS I) comprises a spectrum of clinical manifestations and is divided into three phenotypes reflecting clinical severity: Hurler, Hurler- Scheie, and Scheie syndromes. There may be ...
    • Gonzalez, R.; Arancibia, R.; Cáceres, M.; Martínez, J.; Smith, P.C. (Blackwell Munksgaard, 2009)
      Background and Objective:  Tobacco smoking is a significant risk factor for periodontal disease. It has been suggested that smoking may alter connective tissue remodeling in the periodontium. In the present study, we ...
    • Rojas Sobarzo, Loreto; Olivares Grohnert, Manuel; Brito, Alex; Suazo Romo, Miriam; Araya, Magdalena; Pizarro Aguirre, Fernando (Springer, 2013)
      Copper (Cu) deficiency has been reported to influence lipid metabolism, but the effects in humans are controversial. To evaluate the effects of 8 mg Cu/day supplementation (as copper sulfate) for 6 months on the lipid ...
    • Santos, José Luis; Pérez Bravo, Francisco; Martínez, J. A.; Montalvo, Domingo; Albala Brevis, Cecilia; Carrasco, Elena (Elsevier Science Inc., 2002)
      OBJECTIVE: We assessed the association between Gln27Glu and Trp64Arg genetic polymorphisms of the 2 (ADRB2) and 3 (ADRB3) adrenergic receptor genes with body mass index and other cardiovascular risk factors. METHODS: ...
    • Santibañez, Juan Francisco; Frontelo, Pilar; Iglesias, Maite; Martínez, Jorge; Quintanilla, Miguel (Wiley-Liss, Inc., 1999)
      Transforming growth factor b1(TGF-b1) is a stimulator of malignant progression in mouse skin carcinogenesis. TGF-b1 exerts a differential effect on cultured nontumorigenic (MCA3D cell line) and transformed (PDV cell line) ...
    • Ochoa, María C.; Santos, José Luis; Azcona, Cristina; Moreno Aliaga, María J.; Martínez González, Miguel A.; Martínez, J. Alfredo; Marti, Amelia (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007-12)
      A number of studies have yielded controversial results on the association between polymorphisms in UCP2 and UCP3 genes with obesity and its comorbidities. The discrepancy among studies might be partially explained by the ...
    • Santibáñez, Juan Francisco; Quintanilla, Miguel; Martínez, Jorge (Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies., 2002-04-18)
      We have examined the effect of transforming growth factor L1 (TGF-L1) and overexpression of the Smad4 gene on the phenotype of Car C, a ras mutated highly malignant spindle carcinoma cell line. TGF-L1-treated Car C cells ...
    • Santibañez, Juan Francisco; Guerrero, Javier; Quintanilla, Miguel; Fabra, Angels; Martínez, Jorge (Elsevier Science (USA), 2002-07-15)
      Mouse transformed keratinocytes cultured in the presence of transforming growth factor-b1 (TGF-b1) acquire a set ofmorphological and functional properties giving rise to a more motile phenotype that expresses mesenchymal ...
    • Santibañez, J. F.; Olivares, Daniela; Guerrero, Javier; Martínez, Jorge (Wiley-Liss, Inc., 2003-07-04)
      Mouse-transformed keratinocytes cultured in the presence of transforming growth factor 1 (TGF- 1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal ...
    • Reyes Jedlicki, Marcela; Hoyos, V.; Martínez, S. M.; Lozoff, B.; Castillo Altmann, Marcela; Burrows, Raquel; Blanco, Estela; Gahagan, Sheila (Macmillan, 2013)
      OBJECTIVE: To determine patterns of satiety responsiveness and its relationship to eating in the absence of hunger (EAH), in a cohort of adolescents. We also assessed whether sex, body mass index and duration of breastfeeding, ...
    • Santibañez, J. F. (Stockton Press, 1996)
      Approximately 70% of patients with prostate cancer develop bone metastases in the advanced state of the disease. In the present study, we sought to test the hypothesis that prostatic cancer cells produce factors that ...
    • Reyes Jedlicki, Marcela; Díaz Bustos, Erik; Lera Marques, Lydia; Burrows, Raquel (2011)
      Background: In the last decades, a seven to nine fold increase in the prevalence of teenage obesity and overweight has occurred. Aim: To assess energy intake and metabolism in a sample of overweight and obese adolescents. ...
    • Villarroel, Pia; Reyes Jedlicki, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez Winkler, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana (Springer, 2013)
      We established that human adipose cells and the human adipose cell line LS14 express the calciumsensing receptor (CaSR) and that its activation induces inflammatory cytokine production. Also, its expression is enhanced ...