Now showing items 1-20 of 36

    • Backhouse Erazo, Nadine; Delporte Vergara, Carla; Negrete Córdova, Rosa; Erazo, Silvia; Zúñiga, A.; Pinto, A.; Cassels Niven, Bruce (ELSEVIER SCI IRELAND LTD, 2001-11)
      The antiinflammatory and antipyretic activities of the petroleum ether extract (PEE), dichloromethane extract (DME) and methanol extract (ME1) of the aerial part of Psoralea glandulosa L. (Papilionaceae) were studied. The ...
    • Negrete Córdova, Rosa; Backhouse Erazo, Nadine; Cassels Niven, Bruce (Universidad de Santiago de Chile. Dirección de Investigaciones Científicas y Tecnológicas, 1981)
      El alcaloide principal de las hojas de Sophora macrocarpa Sm. es la matrina. También fueron aisladas e identificadas N-metilcitisina y citisina, asi como N-óxido de matrina y el soforanol (5α -hidroximatrina). Los ...
    • Moroni, Mirko; Zwart, Ruud; Sher, Emanuele; Cassels Niven, Bruce; Bermúdez, Isabel (AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, 2006-08)
      Alpha 4 and beta 2 nicotinic acetylcholine receptor ( nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on ...
    • Duffau, Boris; Camargo Grandón, Rodrigo; Kogan Bocian, Marcelo; Fuentes Pérez, Edwar; Cassels Niven, Bruce (Oxford University Press, 2016)
      Use of unauthorized synthetic drugs is a serious, forensic, regulatory and public health issue. In this scenario, consumption of drug-impregnated blotters is very frequent. For decades, blotters have been generally impregnated ...
    • Duffau, Boris; Camargo Grandón, Cristian; Cassels Niven, Bruce; Kogan Bocian, Marcelo; Fuentes, Edward (Akadémiai Kiadó, 2015)
    • Backhouse,; Delporte,; Negrete,; Salinas,; Pinto Pinto, Andrea Alejandra; Aravena,; Cassels Niven, Bruce (1996)
      The antipyretic and antiinflammatory properties of the infusions and methanol extracts of the whole plant of Cuscuta chilensis Ker-Gawl. and of the aerial parts of Cestrum parqui L'Herit. and Psoralea glandulosa L. were ...
    • Backhouse, N.; Delporte, C.; Negrete, R.; Salinas, P.; Pinto, A.; Aravena, S.; Cassels Niven, Bruce (Swets en Zeitlinger B.V., 1996)
      The antipyretic and antiinflammatory properties of the infusions and methanol extracts of the whole plant of Cuscuta chilensis Ker-Gawl. and of the aerial parts of Cestrum parqui L'Hérit. and Psoralea glandulosa L. were ...
    • Backhouse,; Delporte,; Negrete,; Suarez,; Cassels Niven, Bruce; Breitmaier,; Schneider, (1997)
      Acaena splendens H. et A., Rosacene, has been used in Chilean traditional medicine for the treatment of fever and inflammation. The antipyretic and antiinflammatory properties of the infusion, methanol, petroleum ether and ...
    • Backhouse, N.; Delporte, C.; Negrete, R.; Suárez, S.; Cassels Niven, Bruce; Breitmaier, E.; Schneider, C. (Swets en Zeitlinger B.V., 1997)
      Acaena splendens H. et A., Rosaceae, has been used in Chilean traditional medicine for the treatment of fever and inflammation. The antipyretic and antiinflammatory properties of the infusion, methanol, petroleum ether and ...
    • Arrau, Sylvia; Delporte Vergara, Carla; Cartagena, Carlos; Rodríguez Díaz, Maité; González, Patricia; Silva, Ximena; Cassels Niven, Bruce; Miranda Guzmán, Hugo (Elsevier, 2011-01-07)
      Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine. Aim of the study: The ...
    • Delporte Vergara, Carla; Backhouse Erazo, Nadine; Negrete Córdova, Rosa; Salinas, P.; Rivas Rubio, Paula Andrea; Cassels Niven, Bruce; San Feliciano, Arturo (JOHN WILEY & SONS LTD, 1998-03)
      The acute toxicities of the global methanol extract of Solanum ligustrinum (Solanaceae) and the crude steroidal glycoalkaloids mixture were determined. The antipyretic, hypothermic and antiinflammatory activities of aqueous, ...
    • Speisky Cosoy, Hernán; Cassels Niven, Bruce (1994)
      Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject ...
    • Sobarzo Sánchez, Eduardo; Olea Azar, Claudio; Alarcón, Jaime; Opazo, Lucía; Cassels Niven, Bruce (2003)
      The electrochemical behavior of two representative 2,3-dihydro-7H-dibenzo[de,h]quinolin-7-ones was determined using cyclic voltammetry in DMSO as solvent and rationalized by quantum chemical calculations using ab initio ...
    • Squella Serrano, Juan; Pezzani, M.; Cassels Niven, Bruce; Aillón Torres, Milton; Rezende, Marcos; Núñez Vergara, Luis (1992)
      The amphetamine derivative 4,5‐dimethoxy‐2‐nitrophenyl‐2‐aminopropane, a positional isomer of the potent hallucinogen DON, was studied by cyclic voltammetry and polarography. The nitro compound was reduced to the corresponding ...
    • Araya Maturana, Ramiro; Cassels Niven, Bruce; Delgado Castro, Tomás; Hurtado Guzmán, Claudio; Jullian Matthaei, Carolina (1999)
      The regiosomeric quinones 5-acetyloxymethyl-4,4,8-trimethyl-(5) and 8-acetyloxymethyl-4,4,5-trimethylanthracene-1,9,10(4H)-trione (6) were synthesized and their regiochemistry was assigned on the basis of the unambiguous ...
    • Araya Maturana, Ramiro; Cassels Niven, Bruce; Delgado Castro, Tomás; Hurtado Guzmán, Claudio; Jullian Matthaei, Carolina (JOHN WILEY & SONS LTD, 1999-04)
      The regiosomeric quinones 5-acetyloxymethyl-4,4,8-trimethyl- (5) and 8-acetyloxymethyl-4,4,5-trimethylanthracene-1,9,10(4H)-trione (6) were synthesized and their regiochemistry was assigned on the basis of the unambiguous ...
    • Sobarzo Sánchez, Eduardo; Cassels Niven, Bruce; Jullian Matthaei, Carolina; Castedo, Luis (2003)
      The oxoisoaporphines 2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one, 2,3-dihydro-5-methoxy-7H-dibenzo [de,h] quinolin-7-one, 5-methoxy-6-hydroxy-2,3-dihydro-7H-dibenzo[de,h]quinolin-7-one, 5,6-dimethoxy-2,3-dihydro-7H-dibenz ...
    • Mejías, Lorenzo; Caroli Rezende, Marcos; Sepúlveda Boza, Silvia; Araya Maturana, Ramiro; Boys Mardones, Daphne; Cassels Niven, Bruce; Manríquez Castro, Víctor (SOCIEDAD CHILENA DE QUIMICA, 1998-12)
      An X-ray diffraction study of the 7-bromo-5,8-dihydroxy-4,4-dimethyl-4H-naphthalen--1-one (1), obtained by bromination of 5,8-dihydroxy-4.4-dimethyl-4H-naphthalen-1-one with molecular bromine, gave unambiguous proof of its ...
    • Backhouse Erazo, Nadine; Delporte Vergara, Carla; Negrete Córdova, Rosa; Cassels Niven, Bruce; Schneider, Christiane; Breitmaier, Eberhard; San Feliciano, Arturo (Elsevier Science ltd., 1995)
      Bioactivity guided fractionation of the dichloromethane extract from Psoralea glandulosa yielded the isolation of a diasteromeric mixture of cyclobakuchiols A and B as possible anti-inflammatory active compounds.
    • Yempala, Thirumal; Brea, José; Loza, María Isabel; Matthies, Douglas; Zapata Torres, Gerald; Cassels Niven, Bruce (American Chemical Society, 2020)
      The human 5-HT2 receptor subtypes have high sequence identity in their orthosteric ligand-binding domain, and many agonists are poorly selective between the S-HT(2A )and 5-HT2C subtypes. Nevertheless, their activation is ...