Browsing by Subject "Drug delivery"

Now showing items 1-20 of 21

    • Advances in nanomedicine towards clinical application in oncology and immunology 
      Herreros, Eduardo; Morales, Sebastián; Cortés, Cristian; Cabaña, Mauricio; Peñaloza, Juan P.; Jara, Lilian; Geraldo, Daniela; Otero, Carolina; Fernández-Ramires, Ricardo (Bentham Science Publishers B.V., 2014)
      © 2014, Bentham Science Publishers. Recent advances in nanotechnology and nanobiotechnology have contributed to the development of nanomaterials, able to be used as drug carriers, probes, targets or cytostatic drugs by ...
    • Capping gold nanoparticles with modified chitosan polymers for biomedical applications 
      Mena, Juan F.; Neira Carrillo, Andrónico; Yazdani-Pedram Zobeiri, Mehrdad; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      With the purpose of obtaining stable and non-toxic nanocomposites with potential biomedical applications we coated gold nanoparticles (AuNP) with chitosan (CHI) and CHI grafted with poly(Nisopropilacrylamide) (PNIPAAm) and ...
    • Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles 
      Sierpe, R.; Noyong, Michael; Simon, Ulrich; Aguayo, D.; Huerta, J.; Kogan Bocian, Marcelo; Yutronic Sáez, Nicolás (Elsevier, 2017)
      As a novel strategy to overcome some of the therapeutic disadvantages of 6-thioguanine (TG) and 6-mercaptopurine (MP), we propose the inclusion of these drugs in beta cyclodextrin (beta CD) to form the complexes beta CD-TG ...
    • Cyclodextrin-modified nanomaterials for drug delivery: classification and advances in controlled release ... 
      Real, Daniel Andrés; Bolaños, Karen; Priotti, Josefina; Yutronic Sáez, Nicolás; Kogan, Marcelo Javier; Sierpe Ponce, Rodrigo Eduardo; Donoso González, Orlando Antonio (MDPI, 2021)
      In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the ...
    • Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids 
      Gamboa, Alexander; Schuessler, Nina; Soto Bustamante, Eduardo; Romero Hasler, Patricio; Meinel, Lorenz; Morales, Javier O. (Elsevier, 2020)
      New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-drug conjugates are taking great relevance in the pharmaceutical industry due to their specificity of action and their improved safety ...
    • Exploiting the natural properties of extracellular vesicles in targeted delivery towards specific cells and tissues 
      Lara, Pablo; Chan, Alan B.; Cruz, Luis J.; Quest, Andrew F. G.; Kogan, Marcelo J. (MDPI, 2020)
      Extracellular vesicles (EVs) are important mediators of intercellular communication that participate in many physiological/pathological processes. As such, EVs have unique properties related to their origin, which can be ...
    • Gastric cancer: Nanoparticles as tools to improve treatment efficacy 
      Guerrero, Ariel R.; Oyarzún Ampuero, Felipe; Hassan, Natalia; Corvalán, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham Science, 2016)
      In recent years, advances in nanotechnology have raised the specter of developing effective agents for the treatment of high-impact diseases, like gastric cancer, which remains one of the major causes of cancer deaths ...
    • Gold nanoparticle based double‑labeling of melanoma extracellular vesicles to determine the specificity of ... 
      Lara, Pablo; Palma Florez, Sujey; Salas Huenuleo, Edison; Polakovicova, Iva; Guerrero, Simón; Lobos González, Lorena; Campos, América; Muñoz, Luis; Jorquera Cordero, Carla; Varas Godoy, Manuel; Cancino, Jorge; Arias, Eloísa; Villegas, Jaime; Cruz, Luis J.; Albericio, Fernando; Araya, Eyleen; Corvalán, Alejandro H.; Quest, Andrew F. G.; Kogan Bocian, Marcelo (BMC, 2020)
      Background Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at ...
    • Gold nanoparticle-membrane interactions: Implications in biomedicine 
      Riveros, Ana; Dadlani, Komal; Salas, Edison; Caballero, Leonardo; Melo, Francisco; Kogan Bocian, Marcelo (American Scientific Publishers, 2013)
      There has been an increase in the research towards the use of nanoparticles as a promising tool for nanomedicine, from imagenology, drug and gene delivery, to phototherapy. Little is known regarding the interaction between ...
    • Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 
      Velasco Aguirre, Carolina; Morales Zavala, Francisco; Salas Huenuleo, Edison; Gallardo Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan Bocian, Marcelo (Future Medicine, 2017)
      Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials ...
    • Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide 
      Guerrero, Simon; Araya, Eyleen; Fiedler Temer, Jenny; Arias, J.; Adura, Carolina; Albericio, Fernando; Giralt, Ernest; Arias, José; Fernández, María Soledad; Kogan Bocian, Marcelo (2010)
      Background & aims: Gold nanoparticles (GNPs) have promising applications for drug delivery as well as for the diagnosis and treatment of several pathologies, such as those related to the CNS. However, GNPs are retained in ...
    • Magnetic nanosystem for cancer therapy using oncocalyxone A, an antitomour secondary metabolite isolated ... 
      Barreto, Antônio C.H.; Santiago, Vivian R.; Freire, Rafael M.; Mazzetto, Selma E.; Denardin, Juliano C.; Mele, Giuseppe; Cavalcante, Igor M.; Ribeiro, Maria E.N.P.; Ricardo, Nágila M.P.S.; Gonçalves, Tamara; Carbone, Luigi; Lemos, Telma L.G.; Pessoa, Otília D.L.; Fech (2013)
      This paper describes the investigation and development of a novel magnetic drug delivery nanosystem (labeled as MO-20) for cancer therapy. The drug employed was oncocalyxone A (onco A), which was isolated from Auxemma ...
    • Metal Nanoparticles for the Treatment and Diagnosis of Neurodegenerative Brain Diseases 
      Vio, Valentina; Marchant, María José; Araya, Eyleen; Kogan Bocian, Marcelo (Bentham Science Publishers Ltd., 2017)
      This review focuses on the application of metal nanoparticles in the diagnosis and treatment of Alzheimer's and Parkinson's diseases. Metal nanoparticles present interesting physicochemical properties that can be applied ...
    • Multifunctional polymeric nanoparticles doubly loaded with SPION and ceftiofur retain their physical and ... 
      Solar, Paula; González Moraga, Guillermo; Vilos, Cristian; Herrera, Natalia; Juica, Natalia; Moreno, Mabel; Simón, Felipe; Velásquez, Luis (BIOMED CENTRAL, 2015)
      Background: Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic ...
    • Nanoantioxidant–Based silica particles as flavonoid carrier for drug delivery applications 
      Arriagada, Francisco; Gunther Sapunar, Germán; Morales Valenzuela, Javier (MDPI, 2020)
      Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent ...
    • Nanomedicine and nanotoxicology: the pros and cons for neurodegeneration and brain cancer 
      Catalán Figueroa, Johanna; Palma Florez, Sujey; Alvarez, Gonzalo; Fritz, Hans F.; ara, Miguel O.; Morales, Javier O. (Future Medicine Ltd., 2016)
      Current strategies for brain diseases are mostly symptomatic and noncurative. Nanotechnology has the potential to facilitate the transport of drugs across the blood-brain barrier and to enhance their pharmacokinetic ...
    • Organic and Inorganic Nanoparticles for Prevention and Diagnosis of Gastric Cancer 
      Oyarzún Ampuero, Felipe; Guerrero Hernández, Ariel; Hassan López, Natalia; Morales Valenzuela, Javier; Bollo Dragnic, Soledad; Corvalán Rodríguez, Alejandro; Quest, Andrew F. G.; Kogan Bocian, Marcelo (Bentham, 2015)
      Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists ...
    • Peptides and metallic nanoparticles for biomedical applications 
      Kogan Bocian, Marcelo; Olmedo, Ivonne; Hosta, Leticia; Guerrero, Ariel; Cruz, Luis; Albericio, Fernando (2007)
      In this review, we describe the contribution of peptides to the biomedical applications of metallic nanoparticles. We also discuss strategies for the preparation of peptide-nanoparticle conjugates and the synthesis of the ...
    • Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches 
      Velasco Aguirre, Carolina; Morales, Francisco; Gallardo Toledo, Eduardo; Guerrero, Simón; Giralt, Ernest; Araya, Eyleen; Kogan Bocian, Marcelo (Dove Medical Press, 2015)
      An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration ...
    • Rational design, synthesis and evaluation of γ-CD-containing cross-linked polyvinyl alcohol hydrogel as a ... 
      Marican, Adolfo; Avila-Salas, Fabián; Valdés, Oscar; Wehinger, Sergio; Villaseñor, Jorge; Fuentealba, Natalia; Arenas-Salinas, Mauricio; Argandoña, Yerko; Carrasco-Sánchez, Verónica; Durán-Lara, Esteban F. (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as ...