Now showing items 1243-1262 of 2801

    • Riedel, Clement; Gabizon, Ronen; Wilson Moya, Christian; Hamadani, Kambiz; Tsekouras, Konstantinos; Marqusee, Susan; Presse, Steve; Bustamante, Carlos (Macmillan, 2015)
      Recent studies have shown that the diffusivity of enzymes increases in a substrate-dependent manner during catalysis1,2. Although this observation has been reported and characterized for several different systems3–10, ...
    • Schalscha B., Eduardo; Ahumada Torres, Aída Inés de Lourdes (PERGAMON-ELSEVIER SCIENCE LTD, 1998)
      Industrial and domestic waste waters in Chile are discharged without previous treatment into rivers and other inland waters which are used to irrigate agricultural lands. The present study reports on results obtained when ...
    • Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • Calderón, Inés; Lobos, S.; Mora, Guido C. (Springer-Verlag, 1984)
      Two outer membrane proteins of Salmonella typhi T y 2 were extensively co-purified. According to their migration in dodecyl sulfate/polyacrylamide gel electrophoresis and solubility characteristics, these proteins are ...
    • Olivares Silva, Francisco Javier; Landaeta, Rodolfo; Aránguiz, Pablo; Bolivar, Samir; Humeres Martínez, Claudio; Anfossi, Renatto; Vivar Sánchez, Raúl; Boza Fuentes, Pía; Muñoz Jofré, Claudia; Pardo Jiménez, Viviana Gladys; Peiro, Concepción; Sánchez Ferrer, Carlos; Díaz Araya, Guillermo (Elsevier, 2018)
      Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...
    • Mena, Natalia P.; Esparza, Andrés; Tapia, Victoria; Valdés, Pamela; Núñez González, Marco (2007)
      Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
    • Letelier, María E.; Iturra Montecinos, Pablo; Gallardo Garrido, Carlos (Universidad de Santiago de Chile, 2017)
      Inflammation is a cellular defensive mechanism associated to oxidative stress. The administration of nitrofurantoin, nifurtimox and acetaminophen generates oxidative stress by their biotransformation through CYP450 system. ...
    • Paredes, Felipe; Parra, Valentina; Torrealba, Natalia; Navarro Márquez, Mario F.; Gatica, Damián; Bravo Sagua, Roberto; Troncoso, Rodrigo; Pennanen, Christian; Quiroga, Clara; Chiong Lay, Mario; Caesar, Christa; Taylor, W. Robert; Molgó, Jordi; San Martín, Alejandra; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2016)
      Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
    • Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • Porcal, Williams; Hernández, Paola; González, Mercedes; Ferreira, Ana; Olea Azar, Claudio; Cerecetto, Hugo; Castro, Ana (American Chemical Society, 2008-09)
      New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative ...
    • Martínez Cifuentes, Maximiliano; Weiss López, Boris; Santos, Leonardo S.; Araya Maturana, Ramiro (Bentham Science Publishers B.V., 2015)
      © 2015, Bentham Science Publishers. Curcumin, a natural yellow polyphenol, is isolated from the herb Curcuma longa L. (turmeric), a member of the ginger family. It has been extensively studied due to their multiple ...
    • Martins Alho, Miriam A.; Baggio, Ricardo; Garland, María Teresa; D'Accorso, Norma B.; Varela, Oscar (2002)
      Both thiosemicarbazone groups of the derivative 1 of 3-deoxy-D-erythro-hexos-2-ulose underwent, on acetylation, a heterocyclization process to give (5R,5′R)-2,2′-diacetamido-4,4′-di-N-acetyl-5′-(1- deoxy-2,3,4-tri-O-acet ...
    • Brain Isasi, Stephanie; Álvarez Lueje, Alejandro; Higgins, Thomas Joseph V. (BioMed Central, 2017-06-15)
      Background: Phaseolamin or alpha-amylase inhibitor 1 (alpha AI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian alpha-amylases. Several clinical studies support the ...
    • Larraín Barth, María Angélica; Díaz, Nelson F.; Lamas, Carmen; Uribe, Carla; Jilberto, Felipe; Araneda Tolosa, Cristian (PUCV, 2015)
      Mussels (Mytilus spp.) are one of the most cultivated and commercialized bivalves in southern Chile; culture is currently supplied almost entirely from wild-caught seed obtained from relatively few collection centers. The ...
    • Cancino, P.; Santibañez, L.; Fuentealba Rosas, Patricio; Olea, C.; Vega, Andrés; Spodine Spiridonova, Evgenia (Royal Society of Chemistry, 2018)
      © 2018 The Royal Society of Chemistry. Heterometallic 3d-4f inorganic polymers were prepared using 3,5 pyridinedicarboxylic acid (H2PDC), {[CuLn2(PDC)2(SO4)2(H2O)6]·H2O}n (Ln: SmIII, CuSmPDC, EuIII, CuEuPDC, GdIII, and ...
    • Vega Gálvez, Antonio; López, Jéssica; Torres Ossandón, María José; Galotto, María José; Puente Díaz, Luis; Quispe Fuentes, Issis; Di Scala, Karina (Elsevier, 2014)
      The aim of this study was to evaluate the effects of high hydrostatic pressure (HHP) at 300, 400 and 500 MPa/1, 3 and 5 min on nutritional and antioxidant properties of Cape gooseberry pulp after immediate application ...
    • Castro Álvarez, Alejandro; Gil Sánchez, Yolimar; Llanos, Leonel; Aravena, Daniel (Royal Society of Chemistry, 2020)
      The current figure of merit to evaluate Single Molecule Magnet (SMM) performance is the blocking temperature (T-B). The best SMMs showT(B)values close to liquid nitrogen boiling point (77 K) while their Orbach effective ...
    • Pikov, Víctor; Sridhar, Arun; Lara Peñaloza, Hernán (Frontiers Media SA, 2018-05-01)
      The polycystic ovary syndrome (PCOS) is the most prevalent ovarian pathology in women, with excessive sympathetic activity in the superior ovarian nerve (SON) playing an important role in inducing the PCOS symptoms in the ...
    • Morales, Javier; Zanocco Loyola, Antonio; Günther Sapunar, Germán; Lemp Miranda, Else (2006)
      A high-performance liquid chromatography (HPLC) method for the determination of 2-(4-(N,N,N-trimethyl)-butyl)-5-dodecylfuryl bromide (DFTA) in dipalmitoylphophatidil-choline (DPPC) liposome solutions has been developed. ...
    • Retuert de la Torre, Pedro Jaime; Martínez, Y.; Quijada Abarca, Juan; Yazdani-Pedram Zobeiri, Mehrdad (ELSEVIER SCIENCE BV, 2004-11-01)
      The formation of polymeric hybrid materials of siloxanes with gelatin (GE) starting from sodium metasilicate as the silica source, and their transformation into silica under different conditions have been studied. ...