Browsing by Author "Díaz Araya, Guillermo"

Now showing items 21-40 of 54

    • Gln(27)-> Glu beta(2)-Adrenergic Receptor Polymorphism in Heart Failure Patients: Differential Clinical and ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán S., Juan; Bravo Méndez, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Campo Sfeir, Andrea Estefanía del; Sanhueza Muñoz, Carlos Joaquín; Rodríguez Villarroel, Andrea Elizabeth; Vukasovic Ramírez, José Luis; Mellado, Rose Marie; Greig, Douglas; Castro, Pablo; Lavandero González, Sergio (WILEY-BLACKWELL PUBLISHING, 2009-05)
      We investigated the clinical response of chronic heart failure patients with beta(2)- adrenergic receptor Gln(27)-> Glu polymorphism treated for 6 months with carvedilol, a alpha/beta-antagonist with antioxidant properties. ...
    • Glucose deprivation causes oxidative stress and stimulates aggresome formation and autophagy in cultured ... 
      Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2006-06-12)
      NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...
    • Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (2006)
      NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
    • Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibáñez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (ELSEVIER, 2006-08-07)
      We have recently shown that hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFKB is regulated in cultured ...
    • Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • IGF-1 modulation of rat cardiac fibroblast behavior and gene expression is age-dependent 
      Díaz Araya, Guillermo; Borg, T. K.; Lavandero González, Sergio; Loftis, M. J.; Carver, W. (TAYLOR & FRANCIS LTD, 2003-05)
      The collagenous extracellular matrix (ECM) forms a stress-tolerant network that is essential for proper function of the vertebrate heart. Profound changes have been detected in the interstitial ECM concurrent with developmental ...
    • IGF-1 protects cardiac myocytes from hyperosmotic stress-induced apoptosis via CREB 
      Maldonado, Carola; Cea, Paola; Adasme, Tatiana; Collao, Andrés; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-11-04)
      Hyperosmotic stress stimulates a rapid and pronounced apoptosis in cardiac myocytes which is attenuated by insulin-like growth factor-1 (IGF-1). Because in these cells IGF-1 induces intracellular Ca2+ increase, we assessed ...
    • IGF-1 regulates apoptosis of cardiac myocyte induced by osmotic-stress 
      Morales, María Paz; Gálvez, Anita; Eltit Ortega, José Miguel; Ocaranza, María Paz; Díaz Araya, Guillermo; Lavandero González, Sergio (ACADEMIC PRESS INC, 2000-04-21)
      Insulin-like growth factor-1 (IGF-1) is a natural protectant of cardiac myocytes that has been shown to improve cardiac function. The role of IGF-1 in attenuating apoptosis induced by osmotic stress (sorbitol, SOR) or by ...
    • Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica 
      Greig, Douglas; Castro, Pablo; Gabrielli, Luigi A.; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; Vivar Sánchez, Raúl; Vukasovic Ramírez, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (SOC MEDICA SANTIAGO, 2008-06)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Inflamación y estrés oxidativo en el síndrome coronario agudo: ¿Dos fenómenos relacionados? 
      Bittner, Alex; Castro Gálvez, Pablo; Pérez, Osvaldo; Corbalán, Ramón; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Díaz Araya, Guillermo; Vicencio Bustamante, José Miguel; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zambrano, Juan J.; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2005)
      Hemos descrito un incremento en el estrés oxidativo (EO) en pacientes con síndrome coronario agudo (SCA), relacionado con el fenómeno de isquemia-reperfusión. La inflamación es otra potencial fuente de especies reactivas ...
    • Isoproterenol and angiotensin I-converting enzyme in lung, left ventricle, and plasma during myocardial ... 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Chiong Lay, Mario; Muñoz, David; Riveros, Juan Pablo; Ebensperger González, Roberto; Sabat, Sebastián; Irarrázabal, Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-08)
      This study investigated whether long-term administration of isoproterenol (ISO) induces differential expression of angiotensin-converting enzyme (ACE) in lung, plasma, and left ventricle (LV) during development of left ...
    • La actividad de metaloproteinasa-9 se asocia al estrés oxidativo en el síndrome coronario agudo 
      Bittner, Alex; Castro Gálvez, Pablo; Pérez, Osvaldo; Corbalán, Ramón; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Díaz Araya, Guillermo; Vicencio, José Miguel; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zamorano, Juan J.; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      La metaloproteinasa (MMPs) son enzimas proteolíticas que participan en la inestabilidad de la placa aterosclerótica. En cultivos celulares, la actividad de metaloproteinasas-2 y 9 (MMP-2 y MMP-9) aumenta en presencia de ...
    • A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes 
      Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)
      Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
    • Oxidative stress after reperfusion with primary coronary angioplasty: Lack of effect of glucose-insulin-potassium ... 
      Díaz Araya, Guillermo; Nettle Danniels, Maurice; Castro Agüero, Pablo; Miranda, Fernando; Greig, Douglas; Campos Bastidas, Ximena; Chiong Lay, Mario; Nazal N., Carolina; Corbalán, Ramón; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2002-02)
      Objective: To evaluate the oxidative stress status and the modification with glucose-insulin-potassium (GIK) therapy in patients with acute myocardial infarction undergoing primary percutaneous transluminal coronary ...
    • Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives. ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rose Marie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2007-08)
      Despite advances in treatment, chronic heart failure still is associated with a pool- prognosis and remains a leading cause of cardiovascular death. Cumulatingi evidence sugigest,; that imbalances in redox state lead to a ...
    • Perindopril regulates beta-agonist-induced cardiac apoptosis 
      Gálvez, A. S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2005-09)
      Administration of the P-adrenergic agonist isoproterenol results in cardiac apoptosis. The effect of short-term P-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Perindopril regulates β-agonist-induced cardiac apoptosis 
      Gálvez, Anita S.; Fiedler Temer, Jenny; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio; Díaz Araya, Guillermo (2005)
      Administration of the β-adrenergic agonist isoproterenol results in cardiac apoptosis, The effect of short-term β-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin ...
    • Persistence of oxidative stress after heart transplantation: A comparative study of patients with heart ... 
      Pérez, Osvaldo; Castro Agüero, Pablo; Díaz Araya, Guillermo; Nettle Nettle, Daniels Maurice; Moraga, Francisco; Chiong Lay, Mario; Jalil Milad, Jorge; Zalaquett Sepúlveda, Ricardo; Morán, Sergio; Becker, Pedro; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2002-08)
      Introduction and objective. Chronic heart failure (CHF) is associated with oxidative stress. Heart transplantation, an important therapeutic alternative in these patients, could reduce oxidative stress by improving cardiac ...
    • Pharmacological blockade of NLRP3 inflammasome/IL1β-positive loop mitigates endothelial cell senescence and ... 
      Romero, Alejandra; Dongil, Pilar; Valencia, Inés; Vallejo, Susana; San Hipólito Luengo, Álvaro; Díaz Araya, Guillermo; Bartha, José L.; González Arlanzón, María M.; Rivilla, Fernando; Cuesta, Fernando de la; Sánchez Ferrer, Carlos; Peiró, Concepción (International Society on Aging and Disease, 2022)
      The clinical relevance of IL-1 beta in chronic inflammation underlying atherosclerosis has been reinforced by recent evidence associating pharmacological inhibition of the cytokine with lower cardiovascular risk. Previously, ...