Browsing by Author "Núñez Vergara, Luis"
Now showing items 21-40 of 74
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Electrochemical and EPR characterization of 1,4-dihydropyridines. Reactivity towards alkyl radicals Núñez Vergara, Luis; López Alarcón, Camilo; Navarrete Encina, Patricio; Atria Salas, Ana María; Camargo Grandón, Rodrigo; Squella Serrano, Juan (TAYLOR & FRANCIS LTD, 2003)This work reports the electrochemical oxidation of a series of three synthesized 4-substituted-1,4-dihydropyridine derivatives in different electrolytic media. Also, an EPR characterization of intermediates and the reactivity ...
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Núñez Vergara, Luis; Santander Gutiérrez, Ingrid Paola; Navarrete Encina, Patricio; Valenzuela Pedevila, Jorge; Sturm Schaub, Juan; Squella Serrano, Juan (ELECTROCHEMICAL SOC, 2006)The present paper deals with the electrochemical and electron spin resonance (ESR) characterization of a number of nitroso phenyl 1,4-dihydropyridines in aprotic media on a hanging drop mercury electrode (HDME). The ...
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Bollo Dragnic, Soledad; Muñoz,; Núñez Vergara, Luis; Squella Serrano, Juan (2000)Tacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method for its quantitative determination in pharmaceuticals was developed. Tacrine was ...
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Bollo Dragnic, Soledad; Muñoz, L.; Núñez Vergara, Luis; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2000-03)Tacrine, 9-amino-1,2,3,4-tetrahydroacridine, an antialzheimer's disease agent was electrochemically studied and a polarographic method For its quantitative determination in pharmaceuticals was developed. Tacrine was ...
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Núñez Vergara, Luis; Farías Oddone, Daniel Rodrigo; Bollo Dragnic, Soledad; Squella Serrano, Juan (ELSEVIER SCIENCE, 2001-01)This paper reports the feasibility of free radicals formation from flutamide by using cyclic voltammetry. The electrochemical characteristics and the reactivity of the one-electron reduction product from flutamide in mixed ...
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Núñez Vergara, Luis; Ortiz, Luis J.; Bollo Dragnic, Soledad; Squella Serrano, Juan (1997)This paper reports a comprehensive study by cyclic voltammetry on the electrochemical characteristics and the reactivity of the one-electron reduction product from a series of nitro aryl 1,4-dihydropyridines in mixed and ...
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Núñez Vergara, Luis; Santander, Paola; Navarrete Encina, Patricio; Squella Serrano, Juan (ELSEVIER, 2005-06-15)A comprehensive study of the electrochemical reduction in protic media of parent C-4 nitrophenyl 1,4-DHPs and their corresponding nitrosophenyl 1,4-DHPs was carried out. The reduction potentials of synthesized aromatic ...
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Núñez Vergara, Luis; Bontá, M.; Sturm Schaub, Juan; Navarrete Encina, Patricio; Bollo Dragnic, Soledad; Squella Serrano, Juan (ELSEVIER SCIENCE, 2001-06-15)A comprehensive study of the electrochemical reduction, in different electrolytic media, of two nitroso compounds, i.e. ortho- and meta-nitrosotoluene derivatives has been carried out. Furthermore, UV-vis and EPR spectroscopic ...
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Squella Serrano, Juan; Huerta, M; Bollo Dragnic, Soledad; Pessoa, H; Núñez Vergara, Luis (Elsevier, 1997)The electrochemical reduction of three nitrotetralone derivatives by tast and differential pulse polarography and cyclic voltammetry in a wide pH range was studied. In aqueous media, the reduction of mono- and dinitrotetralone ...
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Squella Serrano, Juan; Sturm Schaub, Juan; Weiss López, Boris; Bontá, M.; Núñez Vergara, Luis (ELSEVIER SCIENCE, 1999-05-14)The electrochemical reduction of a series of beta-nitrostyrene and beta-methyl-beta-nitrostyrene derivatives: by tast and differential pulse polarography and cyclic voltammetry over a wide pH range was studied. The reduction ...
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Álvarez Lueje, Alejandro; Naranjo, Luis; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 1998-01)The anodic and cathodic behavior of nisoldipine, 3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3,5-dicarboxylate, are reported. This drug belongs to the nitroaryl-1,4-dihydropyridine family, known ...
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Squella Serrano, Juan; Núñez Vergara, Luis (1981)
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Squella Serrano, Juan; Bollo Dragnic, Soledad; Fuente Urrutia, Julio de la; Núñez Vergara, Luis (1994)The cyclic voltammetric behavior of nicardipine was studied. Particular attention was directed to the one-electron ArNO2/ArNO2•- couple as measured by the cyclic voltammetric mode in aqueous DMF mixed media. Analysis of ...
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Núñez Vergara, Luis; Salazar González, Ricardo Andrés; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Yáñez Soto, Claudia; Squella Serrano, Juan (ELECTROCHEMICAL SOC, 2007)A study of the electrolytic oxidation of three new C-4 nitrofuryl 1,4-dihydropyridines in nonaqueous aprotic medium is presented. Controlled-potential electrolysis (CPE) in dimethylformamide +0.1 M tetrabutyl-ammonium ...
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Squella Serrano, Juan; Jimenez,; Bollo Dragnic, Soledad; Núñez Vergara, Luis (Elsevier Ltd, 1997)Electrochemical studies on 4-(nitrophenyl) substituted 1,4-dihydropyridines of pharmacological importance have allowed us to generate the one-electron reduction product, the nitro radical anion, ArNȮ- 2 , in aprotic media. ...
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Squella Serrano, Juan; Álvarez Lueje, Alejandro; Sturm,; Núñez Vergara, Luis (1993)A differential pulse polarographic method for the identification and quantitative determination of enoxacin is described. The method is based on the electrochemical reduction of the drug at the dropping mercury electrode. ...
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Squella Serrano, Juan; Perna, S.; Núñez Vergara, Luis (1988)Nifedipine, a calcium antagonist drug, produces a well-defined polarographic wave due to the four-electron, four-proton reduction of the nitro group. This peak is diffusion-controlled and shows a linear dependence on the ...
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Núñez Vergara, Luis; Bollo Dragnic, Soledad; Atria Salas, Ana María; Carbajo, J.; Gunckel, S.; Squella Serrano, Juan (ELECTROCHEMICAL SOC INC, 2002-10)A comprehensive study of the electrochemical characteristics of 2-, 3-, and 4-nitroanisole isomers in three different electrolytic media has been carried out. Furthermore, kinetic characterization of the one-electron ...
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Álvarez Lueje, Alejandro; Vásquez,; Núñez Vergara, Luis; Squella Serrano, Juan (Taylor and Francis Inc., 1998)An analytical chromatographic method for the determination of nimesulide in pharmaceutical forms has been developed. The method is based on high performance liquid chromatographic (HPLC) and electrochemical detection. ...
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Álvarez Lueje, Alejandro; Sturm Schaub, Juan; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE LTD, 2002-06-01)The development of a new HPLC-UV diode array procedure applied to follow the hydrolytic degradation of two well-known 4-nitrophenyl-1,4-dihydropyridine derivatives, nitrendipine and nisoldipine is reported. Hydrolysis of ...