Now showing items 21-40 of 82

    • Zúñiga, María A.; Pérez Roa, Rodolfo E.; Olea Azar, Claudio; Laurie, V. Felipe; Agosin Trumper, Eduardo (Elsevier, 2014)
      In this research, we determined the chemical composition of 37 Vitis vinifera cv. Carme´ne` re wines and established their antioxidant capacity (AC). A set of 26 measurements of chemical species potentially related to ...
    • Paris Pizarro, Irmgard; Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)
      Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
    • Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Navarrete-Encina, Patricio; Squella Serrano, Juan (Elsevier, 1997)
      The present paper reports on the electrochemical characterization by cyclic voltammetry of two 1,4-benzodiazepines, loprazolam and flunitrazepam in protic, aprotic and mixed media. In protic media (ethanol + 15 mM citrate ...
    • Jullian Matthaei, Carolina; Brossard, Victor; González, Iván; Alfaro, Muriel; Olea Azar, Claudio (SPRINGER/PLENUM PUBLISHERS, 2011-04)
      The slightly water-soluble flavonoid kaempferol (KAE) and its inclusion complexes with beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP beta CD) or heptakis-2,6-O-dimethyl-beta-cyclodextrin (DM beta CD) ...
    • Toro, Patricia; Suazo, Constanza; Acuña, Alejandra; Fuentealba, Mauricio; Artigas, Vania; Arancibia, Rodrigo; Olea Azar, Claudio; Moncada, Mauricio; Wilkinson, Shane; Klahn, A. Hugo (Elsevier, 2018)
      A novel series of cyrhetrenyl (3a-4a) and ferrocenyl (3b-4b) Schiff bases were synthesized through a condensation reaction, between the known 4-ferrocenylaniline (2b) or the unreported 4-cyhretrenylaniline (2a) with 4-or ...
    • Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)
      Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
    • Espinoza, M.; Olea Azar, Claudio; Massif, G.; Villa Litovosky, Alberto (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008-12)
      Reference materials are essential tools to achieve comparability and traceability between measurements. However, reference materials in food matrices are scarce. in this article, the development of a reference material for ...
    • Núñez Vergara, Luis; Pardo Jiménez, V; Barrientos, C.; Olea Azar, Claudio; Navarrete-Encina, P. A.; Squella Serrano, Juan (2012)
      In this study, two series of dihydropyridine-fused and pyridine-fused coumarins were synthesised and electrochemically characterised in aprotic medium. In both series, the most easily reducible groups were the endocyclic ...
    • González Fuentes, Pamela A.; Zúniga López, María C.; Olea Azar, Claudio; Loyola, Cristina; Folch Cano, Christian G. (Pontificia Universidad Católica de Chile, 2017)
      The production of high quality natural Antioxidants from olive pruning wood extracts and their application to prevent the oxidation of vegetable oils were evaluated. The production of antioxidants from branches of olive ...
    • Aguilera Venegas, Benjamín; Olea Azar, Claudio; Arán, Vicente J.; Maya Arango, Juan; Kemmerling Weis, Ulrike; Speisky Cosoy, Hernán; Mendizábal Emaldía, Fernando (2012)
      A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
    • Barriga González, Germán; Olivares Petit, Carla; Toro, Patricia M.; Klahn, A. Hugo; Olea Azar, Claudio; Maya Arango, Juan D.; Huentupil, Yosselin; Arancibia, Rodrigo (Soc. Chilena de Química, 2020)
      The bioorganometallic compounds 2-cyrhetrenyl-5-nitro-benzimidazole (Bzn-1) and 2-ferrocenyl-5-nitro-benzimidazole (Bzn-2) have been proposed as potential anti-Trypanosoma cruzi agents. In this regard, electrochemical, ...
    • Olea Azar, Claudio; Alarcón, J.; Opazo, L.; Abarca, B.; Ballesteros, R.; Bielsa, P. (Sociedad Chilena de Quimica, 2002)
      Apomorphine acts as contractile muscular agent through an extra cellular calcium mechanism dependent. This activity is accompanied with autoxidacion process producing o-quinone derivates. o-Quinone is also obtained by ...
    • Olea Azar, Claudio; Abarca, B.; Norambuena, E.; Opazo, L.; Rigol, C.; Ballesteros, R.; Chadlaoui, M. (2005)
      The ESR spectra of radicals obtained by electrolytic reduction of 2-acylpyridines and 6,6′-diacyl-2,2′-bipyridines were measured in dimethylsulfoxide (DMSO) and analyzed by quantum chemical calculations. The electrochemistry ...
    • Aravena, María C.; Figueroa, Roberto; Olea Azar, Claudio; Arán, Vicente J. (2010)
      Cyclic Voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of several potentially antiprotozoal nitro derivatives of dihydroquinoxaline and indazole. A self-protonation process ...
    • Barriga González, Germán; Chamorro, Eduardo; Salinas, Melissa; Modak, Brenda; Olea Azar, Claudio (Sociedad Chilena Química, 2016)
      The antioxidant capacity has been determined for a number of flavonoid compounds from Heliotropium sinuatum, a plant that grows in arid areas in the north of Chile. The methodologies used were: ORAC(FL) (oxygen radical ...
    • Lapier, Michel; Zúñiga López, María C.; Aguilera Venegas, Benjamín; Adam, Rosa; Abarca, Belén; Ballesteros, Rafael; López Muñoz, Rodrigo; Maya Arango, Juan; Olea Azar, Claudio (Bentham Science Publishers B.V., 2017)
      © 2017 Bentham Science Publishers. Trypanosoma cruzi is the causative agent of Chagas disease. This parasite is vulnerable to the effects of ROS as its main defense mechanism against exogenous agents trypanothione is also ...
    • Moncada-Basualto, Mauricio; Lapier, Michel; Maya Arango, Juan; Matsuhiro, Betty; Olea Azar, Claudio; Delogu, Giovanna; Uriarte, Eugenio; Santana, Lourdes; João Matos, María (Bentham Science, 2018)
      Background: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. Objectives: ...
    • Vázquez Rodríguez, Saleta; Guinez, Roberto; Matos, María; Olea Azar, Claudio; Maya Arango, Juan; Uriarte, Eugenio; Santana, Lourdes (Bentham Science, 2016)
      With the aim of finding new chemical entities based on coumarin and chalcone scaffolds, new hybrid compounds 2-5 were designed and synthesized. The trypanocidal activity of these compounds was tested against the epimastigote, ...
    • Gómez, Johana; Klahn, A. Hugo; Fuentealba, Mauricio; Sierra, Diego; Olea Azar, Claudio; Maya Arango, Juan; Medina, Manuela E. (Elsevier, 2017)
      The synthesis of unsymmetrical ferrocenyl and cyrhetrenyl azines [(h5-C5H4)-CR¼N-N¼CH-2-C4H2X-5-NO2]M (M¼Re(CO)3, Fe(h5-C5H5); R¼H, CH3,X¼O, S) has led to the development of new derivativesof 5-nitroheterocycles as potential ...