Browsing by Author "Saitz Barría, Claudio"
Now showing items 21-40 of 41
-
Insuasty, B.; Insuasty, H.; Saitz Barría, Claudio; Quiroga, J.; Jullian Matthaei, Carolina (HETERO CORPORATION, 1999-05)New 4-Aryl-6-methyl-8-phenyl-2,3-dihydropyrazolo[3,4-b]diazepines and 4-aryl-8-methyl-6-phenyl-2,3-dihydropyrazolo[4,3-b]diazepines were obtained from the reaction of 4,5-diamino-3-methyl-1-phenylpyrazole 1 with one ...
-
Pessoa Mahana, Hernán; Kosche Cárcamo, Johann; Ron Higuera, Nadia; Recabarren Gajardo, Gonzalo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Pessoa Mahana, Carlos (2008)A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene ...
-
Pessoa Mahana, Hernán; González, Marcos; González, Marcelo; Pessoa Mahana, David; Araya Maturana, Ramiro; Ron, Nadia; Saitz Barría, Claudio (Arkat, 2009)A series of Michael adducts (5-11) have been synthesized with good yields under solvent-free microwave conditions. Aliphatic and aromatic amines utilized as Michael donors reacted with 1-(4,7-dimethoxybenzo[b]thiophen-2- ...
-
Studies on quinones.209 a convenient approach to the synthesis of 2-acetonylpyranonaphuthoquinones Saitz Barría, Claudio; Valderrama Guerrero, Jaime Adolfo; Tapia, R. (MARCEL DEKKER INC, 1990)a SHORT AND EFFICIENT SYNTHESIS OF 2-ACETONYLPYRANONAPHTHOQUINONES (13 AND 14) STARTING FROM MICHAEL ADDUCT 5 IS DESCRIBED
-
Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Jullian Matthaei, Carolina; Fuente Urrutia, Julio de la; Pessoa Mahana, Hernán; Saitz Barría, Claudio (Springer, 2014)The present work describes a study of complexation efficiency and selectivity of calix[4]arenes bearing benzoimidazolyl, benzothiazolyl, and benzoxazolyl heterocycles (5–7) towards several selected metal ions ...
-
Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)© 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
-
Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
-
Pessoa Mahana, Hernán; Cuevas M., Ignacio; Pessoa Mahana, Carlos David; Araya Maturana, Ramiro; Almodovar, Iriux; Saitz Barría, Claudio (2011)The synthesis of a series of functionalized 1-Benzyl-3-[4-Aryl-1-piperazingl]carbonyl-1H-Indoles 6(a-f), as a potential new class of bioactive ligands at D4 receptors is reported. The synthetic strategy took place through ...
-
Saitz Barría, Claudio; Valderrama Guerrero, Jaime Adolfo; Tapia, R.; Fariña, Francisco; Paredes, M. Carmen (MARCEL DEKKER INC, 1992)The synthesis of pyranoquinone 6 and its application to the elaboration of pyranonaphthoquinone 1b is described.
-
Quiroga, J.; Insuasty, B.; Hormaza, Angela; Saitz Barría, Claudio; Jullian Matthaei, Carolina (HETERO CORPORATION, 1998-05)Reaction of 5-amino-3-methyl-1-phenylpyrazole (1a) and 5-amino-3-(4-chlorophenyl)-1H-pyrazole (1b) with dimedone (2) and p-susbstituted benzaldehydes 3 in ethanol, afforded in all cases tricyclic linear 4-aryl- ...
-
Cañete Molina, Alvaro Félix; Meléndrez Cancino, Mónica Ximena; Saitz Barría, Claudio; Zanocco Loyola, Antonio (MARCEL DEKKER INC, 2001)A very simple and efficient method to prepare aminonaphthalene derivatives in good yield using the Bucherer reaction under microwave irradiation in a closed vessel is described. A reaction time of 30 min at 150 Watts of ...
-
Pessoa Mahana, Hernán; Acevedo Ramos, Armando Rodrigo; Araya Maturana, Ramiro; Saitz Barría, Claudio; Pessoa, D. (TAYLOR & FRANCIS INC, 2007)New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl] ...
-
Torres Pinedo, Antonio; Santoyo González, Francisco; Saitz Barría, Claudio (GEORG THIEME VERLAG, 1999-12)The effective synthesis of a variety of bisthiourea-bridged calix[4]arenes substituted by carbohydrates units (D-glucose, D-mannose, D-galactose and lactose) at the narrow rim by reaction of bis(aminoethoxy)calix[4]arene ...
-
Saitz Barría, Claudio; Fuente, J. de la; Jullian Matthaei, Carolina; Pessoa Mahana, Hernán; Olea, Carolina (SCIENCE REVIEWS LTD, 2008-06)A novel series of calix[4]arenes bearing benzothiazole, benzoxazole, and benzoimidazole groups were obtained by the reaction of the corresponding 2-mercaptoheterocycle with 5,11,17,23-tetra-tert-butyl-25,27-bis[2-(chloroacetamido) ...
-
Quiroga, Jairo; Hormaza, Angelina; Insuasty, Braulio; Saitz Barría, Claudio; Jullian Matthaei, Carolina; Cañete, Alvaro (HeteroCorporation, 1998)A series of pyrazolo[1,5-a]pyrimidin-3-ones 3 was prepared from Meldrum's acid and 5-amino-3-arylpyrazoles 1 by cyclization in nitrobenzene of the corresponding 5-pyrazolylaminomethylene Meldrum's acid derivatives 2. The ...
-
Insuasty, B.; Torres, H.; Quiroga, J.; Abonia, R.; Rodríguez, R.; Nogueras, M.; López Sánchez, A.; Saitz Barría, Claudio; Alvarez, S. L.; Zacchino, Susana (Sociedad Chilena de Química, 2006)The synthesis of a series of new benzimidazo [1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is decsribe. The structure elucidation of the products is based on detailed NMR analysis of experiments ...
-
Insuasty, B. A.; Torres, H.; Quiroga, J.; Abonia, R.; Rodríguez, R.; Nogeras, N.; López Sánchez, Ángel R.; Saitz Barría, Claudio; Alvarez, S. L.; Zacchino, Susana (SOCIEDAD CHILENA DE QUIMICA, 2006-06)The synthesis of a series of new benzimidazo[1,2-c]quinazolines starting from 2-nitrobenzaldehyde and o-phenylendiamine is described. The structure elucidation of the products is based on detailed NMR analysis of experiments ...
-
Pessoa Mahana, Hernán; González Lira, Christian; Fierro, Angélica; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Ortiz Severin, Javiera; Iturriaga-Vásquez, Patricio; Reyes Parada, Miguel; Silva Matus, Paul; Saitz Barría, Claudio; Araya Maturana, Ramiro (Elsevier, 2013)A series of 3-(3-(4-(3-(1H-indol-3-yl)propyl)piperazin-1-yl)propyl)-1H-indole derivatives (3a–d and 5a– f) as homo- and hetero-bis-ligands, were synthesized and evaluated for in vitro affinity at the serotonin transporter ...
-
Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Fiedler Temer, Jenny; Zapata Torres, Gerald Amilcar; Pessoa Mahana, Carlos David; Saitz Barría, Claudio; Araya Maturana, Ramiro (2012)A series of novel benzobthiophen-2-yl-3-(4-arylpiperazin-1-yl)-propan-1-one derivatives 6a–f, 7a–f and their corresponding alcohols 8a–f were synthesized and evaluated for their affinity towards 5-HT1A receptors. The ...
-
Fuente, J. de la; Jullian Matthaei, Carolina; Saitz Barría, Claudio; Neira Pacheco, Verónica Alejandra; Poblete, Oscar.; Sobarzo Sánchez, Eduardo (AMER CHEMICAL SOC, 2005-10-28)Photoreduction of oxoisoaporphine dyes occurs via a stepwise mechanism of electron-protonelectron transfer that leads to the N-hydrogen oxoisoaporphine anion. When triethylamine, TEA, was used as the electron donor in ...