Browsing by Author "Díaz Araya, Guillermo"

Now showing items 41-54 of 54

    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac ... 
      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Polimorfismos de los receptores - β Adrenérgicos y su relación con el riesgo de insuficiencia cardíaca, ... 
      Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Polymorphism in gene coding for ACE determines different development of myocardial fibrosis in rats 
      Ocaranza, María Paz; Díaz Araya, Guillermo; Carreño, J. E.; Muñoz, David; Riveros, Juan Pablo; Jalil Milad, Jorge; Lavandero González, Sergio (AMER PHYSIOLOGICAL SOC, 2004-02-01)
      In humans, the effect of angiotensin-converting enzyme (ACE) gene polymorphisms in cardiovascular disease is still controversial. In the rat, a microsatellite marker in the ACE gene allows differentiation of the ACE gene ...
    • A rapid and strong apoptotic process is triggered by hyperosmotic stress in cultured rat cardiac myocytes 
      Gálvez, Anita; Morales, María Paz; Eltit Ortega, José Miguel; Ocaranza, María Paz; Carrasco Alarcón, Loreto del Pilar; Campos Bastidas, Ximena; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (SPRINGER-VERLAG, 2001-05)
      In all cell types, the maintenance of normal cell volume is an essential homeostatic function. Relatively little is known about the induction of apoptosis by hyperosmotic stress and its molecular mechanism in terminally ...
    • Regulation of Cardiac Autophagy by Insulin-like Growth Factor 1 
      Troncoso, Rodrigo; Díaz Elizondo, Jessica; Espinoza, Sandra P.; Navarro Márquez, Mario F.; Oyarzún, Alejandra P.; Riquelme, Jaime A.; García Carvajal, Ivonne; Díaz Araya, Guillermo; García Nannig, Lorena; Hill, Joseph A.; Lavandero González, Sergio (2013-07)
      Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase ...
    • Relation between oxidative stress, catecholamines, and impaired chronotropic response to exercise in patients ... 
      Castro, Pablo; Greig, Douglas; Pérez, Osvaldo; Moraga, Francisco; Chiong Lay, Mario; Díaz Araya, Guillermo; Padilla, Ivonne; Nazzal Nazal, Carolina; Jalil Milad, Jorge; Vukasovic Ramírez, José Luis; Moreno, M.; Corbalán, Ramón; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-07-15)
    • Scavenging of the one-electron reduction product from nisoldipine with relevant thiols: Electrochemical and ... 
      Núñez Vergara, Luis; Díaz Araya, Guillermo; Olea Azar, Claudio; Atria Salas, Ana María; Bollo Dragnic, Soledad; Squella Serrano, Juan (1998)
      Purpose. To determine the formation of the one-electron reduction product from nisoldipine and its reactivity with relevant thiols in mixed medium. Methods. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) ...
    • Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Chiong Lay, Mario; Verdejo, Hugo; Miranda, Rodrigo; Concepción, Roberto; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; González, Leticia; Godoy, Iván; Castro, Pablo; Lavandero González, Sergio (ELSEVIER, 2008-07)
      Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This ...
    • Simvastatin alters fibroblastic cell responses involved in tissue repair 
      Cáceres, M.; Romero, A.; Copaja, M.; Díaz Araya, Guillermo; Martinez, J.; Smith, P. C. (2011)
    • Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability 
      Copaja, Miguel; Venegas, Daniel; Aranguiz, Pablo; Canales, Jimena; Vivar, Raúl; Avalos, Yennifer; García Nannig, Lorena; Chiong Lay, Mario; Olmedo, Ivonne; Catalán, Mabel; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2012)
      Statins reduce the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac ...
    • Sistemas de transducción de señales en la hipertrofia cardíaca 
      Carrasco Alarcón, Loreto del Pilar; Chiong Lay, Mario; Ibarra Iribarren, Cristián; Campos Bastidas, Ximena; Tello, Mario; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      Los cardiomiocitos son células terminalmente diferenciadas que cesan de dividirse inmediatamentre despúes del nacimiento. Esto hace del corazón un órgano muy vulnerable a eventos isquémicos, tóxicos e inflamatorios. La ...
    • The role of uric acid in heart failure 
      Alcaíno Olivares, Hernán Alejandro; Greig, Douglas; Castro Agüero, Pablo; Verdejo, Hugo; Mellado, Rose Marie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga Lagos, Clara; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2011-04)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...
    • Variantes genéticas de los receptores adrenérgicos y enfermedades cardiovasculares 
      Díaz Araya, Guillermo; Chiong Lay, Mario; Moraga, Francisco; Castro Agüero, Pablo; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Nazzal Nazal, Carolina; Padilla, Ivonne; Corbalán, Ramón; Moreno, Mauricio; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      El proyecto Genoma Humano ha logrado descifrar la secuencia completa del genoma, aportando una herramienta única para el estudio de la genética humana. Sin embargo, se ha observado cada vez más frecuentemente la aparición ...