Browsing by Author "Lavandero González, Sergio"

Now showing items 41-60 of 184

    • Diabetic cardiomyopathy and metabolic remodeling of the heart 
      Battiprolu, Pavan K.; López Crisosto, Camila; Wang, Zhao V.; Nemchenko, Andriy; Lavandero González, Sergio; Hill, Joseph A. (2013)
      The incidence and prevalence of diabetes mellitus are both increasing rapidly in societies around the globe. The majority of patients with diabetes succumb ultimately to heart disease, much of which stems from atherosclerotic ...
    • Diferencias genéticas en la disminución del colesterol por estatinas en pacientes chilenos con cardiopatia ... 
      Noriega Sepúlveda, Viviana Carolina; Pennanen Saavedra, Christian; Llancaqueo Valeri, Marcelo; Lavandero González, Sergio; Prieto Domínguez, Juan (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2007)
      Las estatinas son fármacos de elección para el tratamiento de hipercolesterolemia. Sin embargo, dado que existe una considerable variabilidad interindividual en la reducción del colesterol, la evaluación farmacogenética ...
    • Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death ... 
      Aránguiz Urroz, Pablo Daniel; Soto Muñoz, Dagoberto; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Montenegro Obregón, José Joaquín; Venegas Pino, Daniel Esteban; Smolic Smolic, Christian; Ayala Jeria, Pedro Segundo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (NATURE PUBLISHING GROUP, 2009-05)
      The Angiotensin II (Ang II) type 1 (AT(1)R) and type 2 (AT(2)R) receptors are increased in the heart following myocardial infarction and dilated cardiomyopathy, yet their contribution at a cellular level to compensation ...
    • Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network 
      Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Early prevention of experimental left ventricular hypertrophy in experimental hypertension and angiotensin ... 
      Gálvez, Anita; Ocaranza, María Paz; Lavandero González, Sergio; Jalil Milad, Jorge (EDICIONES DOYMA S/L, 2001-11)
      Introduction. Angiotensin II levels can be partially inhibited during chronic administration of angiotensin converting enzyme (ACE) inhibitors, limiting from a clinical point of view its efficacy in the treatment of ...
    • Efectos del carvedilol en la capacidad funcional, función ventricular izquierda, catecolaminas y estrés ... 
      Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (Sociedad Española de Cardiología, 2004)
      El carvedilol es un antagonista adrenérgico con acción antioxidante y un demostrado beneficio sobre la mortalidad en insuficiencia cardíaca (IC). El objetivo de este estudio es evaluar, en pacientes con insuficiencia ...
    • Effect of hypertension on angiotensin-(1-7) levels in rats with different angiotensin-I converting enzyme ... 
      Ocaranza, María Paz; Palomera, Cristián; Román, Maritza; Bargetto, Jorge; Lavandero González, Sergio; Jalil Milad, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2006-02-28)
      To determine circulating angiotensin-(1-7) [Ang-(1,7)] levels in rats with different angiotensin converting enzyme (ACE) genotypes and to evaluate the effect of hypertension on levels of this heptapeptide, plasma levels ...
    • Effect of inhibitors of signal transduction on IGF-1-induced protein synthesis associated with hypertrophy ... 
      Lavandero González, Sergio; Foncea Avila, Rocío; Pérez, V.; Sapag Hagar, Mario (ELSEVIER SCIENCE BV, 1998-01-30)
      IGF-1 increased 2-fold protein synthesis in cardiac myocytes. Genistein, whether added during preincubation or with IGF-I at the start of incubation, significantly inhibited the IGF-1-induced stimulation of protein synthesis, ...
    • Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat 
      Jalil Milad, Jorge; Ebensperger González, Roberto; Meléndez Vergara, Jaime; Acevedo, E.; Sapag Hagar, Mario; González Jara, Fabián Rodrigo; Gálvez, Anita; Pérez Montes, Viviana; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 1999-03-26)
      There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the ...
    • Effects of atorvastatin therapy in heart failure: Oxidative stress, inflammation, endothelial dysfunction ... 
      Miranda, Rodrigo; Castro, Pablo; Verdejo, Hugo; Greig, Douglas; Alcaíno Olivares, Hernán Alejandro; Bustos Contreras, Carlos Andrés; Vukasovic Ramírez, José Luis; Godoy, Iván; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2007-03-06)
      Meeting Abstract
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso, Rodrigo; Padilla, Ivonne; Vukasovic, Jose L.; Corbalán, Ramón; Lavandero González, Sergio (Ediciones Doyma, S.L., 2004)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Effects of carvedilol on functional capacity, left ventricular function, catecholamines and oxidative stress ... 
      Castro Agüero, Pablo; Pérez, Osvaldo; Greig, Douglas; Díaz Araya, Guillermo; Moraga, Francisco; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Padilla, Ivonne; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Lavandero González, Sergio (EDICIONES DOYMA S/L, 2004-11)
      Introduction and objective. Carvedilol is an antioxidant and adrenergic antagonist with demonstrated benefits in terms of mortality from heart failure (HF). The aim of the present study was to evaluate clinical parameters, ...
    • Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure 
      Castro, Pablo; Mac Nab, Paul; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • Effects of early decrease in oxidative stress after medical therapy in patients with class IV congestive ... 
      Castro, Pablo; Díaz Araya, Guillermo; Nettle Danniels, Maurice; Corbalán, Ramón; Pérez, Osvaldo; Nazzal Nazal, Carolina; Larrain, Germán; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2002-01-15)
      It has been reported that patients with congestive heart failure (CHF) have increased breath pentane content, conjugated diene levels, and plasma malondialdehyde (MDA) levels, an indirect marker of lipid peroxidation.(1-3) ...
    • Emerging role of mitophagy in cardiovascular physiology and pathology 
      Morales, Pablo E.; Arias Durán, Carla; Ávalos Guajardo, Yáreni; Aedo, Geraldine; Verdejo, Hugo E.; Parra Ortiz, Valentina; Lavandero González, Sergio (Elsevier, 2020)
      Healthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial ...
    • Endocytic pathway of exogenous iron-loaded ferritin in intestinal epithelial (Caco-2) cells 
      Antileo, Elmer; Garri, Carolina; Tapia, Victoria; Muñoz, Juan Pablo; Chiong Lay, Mario; Nualart, Francisco; Lavandero González, Sergio; Díaz Fernández, Juan Cristóbal; Núñez González, Marco (American Physiological Society, 2013)
      Ferritin, a food constituent of animal and vegetal origin, is a source of dietary iron. Its hollow central cavity has the capacity to store up to 4,500 atoms of iron, so its potential as an iron donor is advantageous to ...
    • Endoplasmic reticulum: ER stress regulates mitochondrial bioenergetics 
      Bravo Sagua, Roberto; Gutiérrez, Tomás; Paredes, Felipe; Gatica, Damián; Rodríguez, Andrea E.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Parra, Valentina; Quest, Andrew F. G.; Rothermel, Beverly A.; Lavandero González, Sergio (Elsevier, 2012)
      Endoplasmic reticulum (ER) stress activates an adaptive unfolded protein response (UPR) that facilitates cellular repair, however, under prolonged ER stress, the UPR can ultimately trigger apoptosis thereby terminating damaged ...
    • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome ... 
      Kim, Soo Young; Zhang, Xin; Schiattarella, Gabriele G.; Altamirano, Francisco; Ramos, Thais; French, Kristin M.; Jiang, Nan; Szweda, Pamela A.; Evers, Bret M.; May, Herman; Luo, Xiang; Li, Hongliang; Szweda, Luke; Maracajá Coutinho, Vinicius; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Lippincott Williams & Wilkins, 2020)
      BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
    • Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and ... 
      Michea Acevedo, Luis; Delpiano Barriga, Ana María; Hitschfeld, C.; Lobos González, Lorena; Lavandero González, Sergio; Marusic, Elisa (ENDOCRINE SOC, 2005-03)
      There is increasing evidence for rapid nongenomic effects of aldosterone. Aldosterone has been demonstrated to alter intracellular pH and calcium in isolated cells. However, few studies have correlated these effects with ...
    • Erratum 2: Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 ... 
      Altamirano, Francisco; Oyarce, César; Silva, Patricia; Toyos, Marcela; Wilson, Carlos; Lavandero González, Sergio; Uhlen, P.; Estrada, M. (BIOSCIENTIFICA LTD, 2009-09)
      Correction.