Browsing by Author "Chiong Lay, Mario"

Now showing items 61-72 of 72

    • Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in ... 
      Ocaranza, María Paz; Rivera, Paulina; Novoa, Ulises; Pinto, Melissa; González, Leticia; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (LIPPINCOTT WILLIAMS & WILKINS, 2011-04)
      Background Angiotensin II (Ang II) levels depend on renin, angiotensin-converting enzyme (ACE), and on the homologous angiotensin-converting enzyme (ACE2). Increased ACE and Ang II levels are associated with higher Rho ...
    • Rho/Rho kinase signal transduction pathway in cardiovascular disease and cardiovascular remodeling. La ... 
      Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (EDICIONES DOYMA S/L, 2005-08)
      The small guanosine triphosphatase Rho and its target, Rho kinase, play important roles in both blood pressure regulation and vascular smooth muscle contraction. Rho is activated by agonists of receptors coupled to cell ...
    • Serum uric acid correlates with extracellular superoxide dismutase activity in patients with chronic heart failure 
      Alcaíno Gálvez, Hernán Alejandro; Greig, Douglas; Chiong Lay, Mario; Verdejo, Hugo; Miranda, Rodrigo; Concepción, Roberto; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Mellado, Rose Marie; García Nannig, Lorena; Salas, Daniela; González, Leticia; Godoy, Iván; Castro, Pablo; Lavandero González, Sergio (ELSEVIER, 2008-07)
      Increased serum uric acid has been identified as an independent risk factor for cardiovascular disease. However, because of its antioxidant capacity, uric acid may play a beneficial role in endothelial function. This ...
    • Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability 
      Copaja, Miguel; Venegas, Daniel; Aranguiz, Pablo; Canales, Jimena; Vivar, Raúl; Avalos, Yennifer; García Nannig, Lorena; Chiong Lay, Mario; Olmedo, Ivonne; Catalán, Mabel; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2012)
      Statins reduce the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac ...
    • Sistemas de transducción de señales en la hipertrofia cardíaca 
      Carrasco Alarcón, Loreto del Pilar; Chiong Lay, Mario; Ibarra Iribarren, Cristián; Campos Bastidas, Ximena; Tello, Mario; Sapag Hagar, Mario; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      Los cardiomiocitos son células terminalmente diferenciadas que cesan de dividirse inmediatamentre despúes del nacimiento. Esto hace del corazón un órgano muy vulnerable a eventos isquémicos, tóxicos e inflamatorios. La ...
    • The role of uric acid in heart failure 
      Alcaíno Olivares, Hernán Alejandro; Greig, Douglas; Castro Agüero, Pablo; Verdejo, Hugo; Mellado, Rose Marie; García Nannig, Lorena; Díaz Araya, Guillermo; Quiroga Lagos, Clara; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2011-04)
      Complications and mortality of heart failure are high, despite the availability of several forms of treatment. Uric acid, the end product of purine metabolism would actively participate in the pathophysiology of heart ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...
    • (TTA)n Polymorphism in 3-Hydroxy-3-Methylglutaryl-Coenzyme A and Response to Atorvastatin in Coronary Artery ... 
      Noriega Sepúlveda, Viviana Carolina; Pennanen Saavedra, Christian; Sánchez, P.; Chiong Lay, Mario; Llancaqueo Valeri, Marcelo; Lavandero González, Sergio; Prieto Domínguez, Juan (WILEY-BLACKWELL PUBLISHING, 2009-03)
      3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors have been used clinically for lowering total and low-density lipoprotein cholesterol. Interindividual pharmacological differences observed with this treatment have ...
    • Uric acid, xanthine oxidase and heart failure: Unresolved issues 
      Verdejo, Hugo; Greig, Douglas; Castro, Pablo; Alcaíno Olivares, Hernán Alejandro; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio; Pizarro, Marcela (OXFORD UNIV PRESS, 2008-12)
    • Variantes genéticas de los receptores adrenérgicos y enfermedades cardiovasculares 
      Díaz Araya, Guillermo; Chiong Lay, Mario; Moraga, Francisco; Castro Agüero, Pablo; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Nazzal Nazal, Carolina; Padilla, Ivonne; Corbalán, Ramón; Moreno, Mauricio; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      El proyecto Genoma Humano ha logrado descifrar la secuencia completa del genoma, aportando una herramienta única para el estudio de la genética humana. Sin embargo, se ha observado cada vez más frecuentemente la aparición ...
    • La vía de señalización Rho/Rho-cinasa en la enfermedad y el remodelado cardiovascular 
      Jalil Milad, Jorge; Lavandero González, Sergio; Chiong Lay, Mario; Ocaranza, María Paz (Sociedad Española de Cardiología, 2005)
      La guanosina trifosfatasa pequeña Rho y su blanco Rho-cinasa desempeñan un papel importante en la regulación de la presión arterial y en la contracción de la musculatura lisa vascular. Diversos agonistas de los receptores ...
    • Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters 
      Greig, Douglas; Alcaíno Gálvez, Hernán Alejandro; Castro Gálvez, Pablo; García Nannig, Lorena; Verdejo, Hugo E.; Navarro, Mario; López, Rafael; Mellado, Rose Marie; Tapia Mamani, Fabiola Karina; Gabrielli, Luigi A.; Nogerol, Camilo; Chiong Lay, Mario; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2011-04)
      Increased oxidative stress in heart failure (HF) leads to inflammation and endothelial dysfunction (ED). Both statins and allopurinol have known anti-oxidant properties, but their utility in HF has not been fully assessed.