Browsing by Author "Núñez Vergara, Luis"
Now showing items 61-74 of 74
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Pardo Jiménez, Viviana Gladys; Barrientos, C.; Pérez Cruz, Karina Angélica; Navarrete Encina, Patricio; Olea Azar, Claudio; Núñez Vergara, Luis; Squella Serrano, Juan (2014)In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
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Systematic HPLC study of a new series of 4-methyl-1,4-dihydropyridines with antitrombotic activity Núñez Vergara, Luis; Álvarez Lueje, Alejandro; Sturm,; Sunkel,; Squella Serrano, Juan (Marcel Dekker Inc., 1998)A systematic study of a new series of 4-methyl-1,4-dihydropyridine derivatives by HPLC by both photodiode array and electrochemical detectors is reported. The optimum mobile phase was acetonitrile/0.05 M phosphate buffer ...
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Maya Arango, Juan; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Rodríguez, Andrés; Puebla, P.; Caballero S., Esther; Medarde, M.; Núñez Vergara, Luis; Squella Serrano, Juan; Ortíz Yáñez, María Eugenia; Fuentealba, J.; San Feliciano, Arturo (ACADEMIC PRESS INC, 2001-09)Chagas' disease constitutes a therapeutic challenge because presently available drugs have wide toxicity to the host and are generally ineffective in the chronic stages of the disease. A series of oxazolo(thiazolo)pyridene ...
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Argüello da Silva, Jacqueline; Barría, Claudio Saitz; Jullian Matthaei, Carolina; Navarrete, Patricio; Núñez Vergara, Luis; Squella Serrano, Juan (2005)1,4-dihydropyridine derivatives constitute an important pharmacological group for the treatment of cardiovascular diseases. We have synthesised a series 4-(5′-nitro-2′-furyl)-1,4-dihydropyridine derivatives, which were ...
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Santander,; Núñez Vergara, Luis; Sturm,; Squella Serrano, Juan (2001)Melatonin and Vitamin B6 can be oxidized at the glassy carbon electrode showing well-resolved anodic peaks by differential pulse voltammetry. Vitamin B6 shows an oxidation peak potential of about 650 mV vs Ag/AgCI in ammonia ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Patriarche, G. J. (1986)Trazodone, a triazolopyridine derivative with antidepressant activity, is irreversibly oxidized in two steps in a large range of scan rates. The first peak shows a linear dependence on trazodone concentration. This behaviour ...
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Voltammetric behavior of zaleplon and its differential pulse polarographic determination in capsules Larenas Gutiérrez, Gipsy; Bollo Dragnic, Soledad; Rodríguez, M.; Lemus Gutiérrez, Igor; Núñez Vergara, Luis; Squella Serrano, Juan; Álvarez Lueje, Alejandro (AOAC INTERNATIONAL, 2005-07)In this work both the electrochemical behavior and the analysis of the hypnotic pyrazolopyrimidine derivative zaleplon were studied. Zaleplon in ethanol-0.1 M Britton Robinson buffer solution (30-70) showed 2 irreversible, ...
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Squella Serrano, Juan; Lemus, I.; Sturm, J. C.; Núñez Vergara, Luis (Taylor and Francis Inc., 1997)Ketorolac is an antiinflammatory-analgesic agent that is oxidizable at the glassy carbon electrode. The voltammetric oxidation produces two well resolved pH-dependent peaks, that are overlapped at pH>10. Using this ...
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Jara Ulloa, Paola Andrea; Salgado Figueroa, Paola; Yañez,; Núñez Vergara, Luis; Squella Serrano, Juan (2012)We report the adsorptive voltammetric determination of nifedipine on multiwalled carbon nanotubes (MWCNT)-modified glassy carbon electrode (GCE). Nifedipine was adsorbed on the MWCNT and then reduced using linear sweep and ...
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Bollo Dragnic, Soledad; Jara Ulloa, Paola Andrea; Zapata Torres, Gerald; Cutiño,; Sturm,; Núñez Vergara, Luis; Squella Serrano, Juan (Elsevier Ltd, 2010)The voltammetric reduction of 1-methyl- and 1-H- 4-nitroimidazole derivatives was studied in different protic and aprotic media to investigate the influence of the N-1 substitution in the mechanism of reduction, the ...
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Álvarez Lueje, Alejandro; Brain Isasi, B.; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE BV, 2008-05-15)Finasteride in hydroalcoholic solutions (ethanol/Britton-Robinson buffer, 30/70) exhibits cathodic response in a wide range of pH (-0.5 to 12) using differential pulse (DPP) and tast polarography (TP). The reduction peak ...
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Núñez Vergara, Luis; Squella Serrano, Juan; Berrios Sagredo, (1983)
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Sturm,; Canelo,; Núñez Vergara, Luis; Squella Serrano, Juan (Elsevier B.V., 1997)A differential pulse polarographic method for the quantitative determination of ketorolac is described. Ketorolac is an antiinflammatory-analgesic agent that is directly electroreducible at the mercury electrode. The ...
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Álvarez Lueje, Alejandro; Vásquez, P.; Núñez Vergara, Luis; Squella Serrano, Juan (Wiley-VCH Verlag, 1997)Nimesulide, N‐(4‐nitro‐2‐phenoxyphenyl)methanesulfonamide is an antiinflamatory analgesic agent that is both reducible at the mercury electrode and oxidizable at the glassy carbon electrode. Nimesulide in hydroalcoholic ...