Now showing items 61-80 of 82

    • Fernández, Mariana; Rodríguez Arce, Esteban; Sarniguet, Cynthia; Morais, Tânia S.; Tomaz, Ana Isabel; Olea Azar, Claudio; Figueroa, Roberto; Maya Arango, Juan; Medeiros, Andrea; Comini, Marcelo; Garcia, M. Helena; Otero, Lucía; Gambino, Dinorah (Elsevier, 2015)
      Searching for new prospective antitrypanosomal agents, three novel Ru(II)-cyclopentadienyl compounds, [Ru(eta(5)-C5H5)(PPh3)L], with HL = bioactive 5-nitrofuryl containing thiosemicarbazones were synthesized and characterized ...
    • Fuentealba Castro, Pablo; Olea Azar, Claudio; Aguilar Bolados, H.; Audebrand, N.; Santana, R. C. de; Doerenkamp, C.; Eckert, H.; Magon, C. J.; Spodine Spiridonova, Evgenia (Royal Society of Chemistry, 2020)
      Four bimetallic phases of the thiophosphate family have been synthesized by the cationic exchange reaction using a freshly prepared K0.5Cd0.75PS3 precursor phase and methanolic solutions of nitrates of the divalent cations ...
    • Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Aravena, María C.; Olea Azar, Claudio; Cerecetto, Hugo; González, Mercedes; Maya Arango, Juan; Rodríguez Becerra, Jorge (2011)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
    • López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)
      Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
    • Laurie, V. Felipe; Zúñiga, María C.; Carrasco Sánchez, Verónica; Santos, Leonardo S.; Cañete, Álvaro; Olea Azar, Claudio; Ugliano, Maurizio; Agosin Trumper, Eduardo (Elsevier, 2012)
      Volatile species with thiol functions are important contributors to the flavour of a wide variety of wine types. However, in spite of their importance, their fate during winemaking has not been fully elucidated. In this ...
    • Núñez Vergara, Luis; Bollo Dragnic, Soledad; Olea Azar, Claudio; Santander, Paola; Gunckel, Soledad; Squella Serrano, Juan (Sociedad Chilena de Química, 1998)
      This paper reports the scavenging of the nitro radical anion of nisoldipine by N-acetylcysteine assessed by cyclic volatammetry (CV) and EPR spectroscopic techniques. Studies by CV on the reactivity of the radical were ...
    • Aliaga, Margarita E.; López Alarcón, Camilo; Barriga, Germán; Olea Azar, Claudio; Speisky Cosoy, Hernán (2010)
      Prompted by the recently reported capacity of the physiologically occurring Cu(I)-[glutathione]2 complex (Cu(I)-[GSH)]2) to reduce oxygen, the effect of various GSH-binding metals (Co2+, Cd2+, Zn2+, Pb2+, Al3+, Hg2+ and ...
    • Fernández, Luciana A.; Santo, Marisa R.; Reta, Mario; Giacomelli, Liliana; Cattana, Rosa; Silber, Juana J.; Risso, Mariela; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio (MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, 2005-09)
      The relationship between the herbicidal activity of a number of novel 1,2,5- oxadiazole N-oxides and some physicochemical properties potentially related with this bioactivity, such as polarity, molecular volume, proton ...
    • Speisky Cosoy, Hernán; López Alarcón, Camilo; Olea Azar, Claudio; Sandoval-Acua, Cristian; Aliaga, Margarita E. (2011)
      The physiologically occurring copper-glutathione complex, [Cu(I)-[GSH]2], has the ability to react continually with oxygen, generating superoxide anions (O 2 -). We addressed here the effects that superoxide removal has ...
    • Núñez Vergara, Luis; Díaz Araya, Guillermo; Olea Azar, Claudio; Atria Salas, Ana María; Bollo Dragnic, Soledad; Squella Serrano, Juan (1998)
      Purpose. To determine the formation of the one-electron reduction product from nisoldipine and its reactivity with relevant thiols in mixed medium. Methods. Cyclic voltammetry (CV) and electron paramagnetic resonance (EPR) ...
    • Jullian Matthaei, Carolina; Cifuentes, Constanza; Alfaro, Muriel; Miranda, Sebastián; Barriga, Germán; Olea Azar, Claudio (2010)
      The inclusion complexes of Luteolin (LU) with cyclodextrins (CDs) including β-cyclodextrin (βCD), hydroxypropyl-β-cyclodextrin (HPβCD) and dimethyl-β-cyclodextrin (DMβCD), Scheme 1, have been investigated using the method ...
    • Ferrada, Evandro; Arancibia, Verónica; Loeb, Bárbara; Norambuena, Ester; Olea Azar, Claudio; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE BV, 2007-05)
      Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer’s disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of ...
    • Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar; Arán, Vicente; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)
      New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...
    • Aliaga, Margarita; Carrasco Pozo, Catalina; López Alarcón, Camilo; Olea Azar, Claudio; Speisky Cosoy, Hernán (2011)
      The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH](2)) has the ability to reduce molecular oxygen into superoxide radicals (O-2(center dot-)). Based on such ability, we addressed the potential of this ...
    • Pérez Cruz, Karina Angélica; Moncada-Basualto, Mauricio; Morales Valenzuela, Javier; Barriga González, Germán; Navarrete Encina, Patricio; Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio (Elsevier, 2018-05)
      The antioxidant capacity of hydroxylated coumarins and hydroxybenzoic acids has been widely described. However, there is little information on the antioxidant activity when both systems are functionalized. In this work, ...
    • Pérez Cruz, Fernanda; Vazquez Rodriguez, Saleta; Matos, Maria João; Herrera Morales, Alejandra; Villamena, Frederick A.; Das, Amlan; Gopalakrishnan, Bhavani; Olea Azar, Claudio; Santana, Lourdes; Uriarte, Eugenio (2013)
      A series of novel hydroxy-coumarin-chalcone hybrid compounds 2a-i has been synthesized by employing a simple and efficient methodology. An electrochemical characterization using cyclic voltammetry and ESR spectroscopy were ...
    • Pardo Jiménez, Viviana Gladys; Barrientos, C.; Pérez Cruz, Karina Angélica; Navarrete Encina, Patricio; Olea Azar, Claudio; Núñez Vergara, Luis; Squella Serrano, Juan (2014)
      In this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemically characterized in dimethylformamide (DMF). Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
    • Pardo Jiménez, Viviana Gladys; Barrientos, C.; Pérez Cruz, Karina Angélica; Navarrete Encina, Patricio; Olea Azar, Claudio; Núñez Vergara, Luis; Squella Serrano, Juan (Elsevier, 2013)
      tIn this paper, a series of six dihydropyridine-fused coumarins were synthesized and electrochemicallycharacterized in dimethylformamide (DMF).Dihydropyridine ring oxidation on glassy carbon electrode (GCE) for condensed ...
    • Barriga González, G.; Aliaga, C.; Chamorro, E.; Olea Azar, Claudio; Norambuena, E.; Porcal, W.; González, M.; Cerecetto, H. (Royal Society of Chemistry, 2020)
      A new series of heteroaryl nitrones were synthesized and evaluated as free radical traps due to the results showed in our previous report. The physicochemical characterization of these new nitrones by electron spin resonance ...