Browsing by Author "Aracena Parks, Paula"

Now showing items 1-7 of 7

    • ANTIOXIDANT PROPERTIES OF Rosmarinus officinalis AND ITS EFFECTS ON XENOBIOTIC BIOTRANSFORMATION 
      Letelier Muñoz, María Eugenia; Terán, A.; Barra, M. A.; Aracena Parks, Paula (Jose L. Martinez, 2009-11-30)
      Rosmarinus officinalis (rosemary) extracts display antioxidant properties mainly due to the presence of polyphenols. These properties have yet to be systematically studied in biological systems. In this study, we used rat ...
    • Copper modifies liver microsomal UDP-glucuronyltransferase activity through different and opposite mechanisms 
      Letelier Muñoz, María Eugenia; Lagos, Fernando; Faúndez, Mario; Miranda, Dante; Montoya, Margarita; Aracena Parks, Paula; González Lira, Víctor (ELSEVIER IRELAND LTD, 2007-04)
      Treatment of hepatic microsomes with Fe3+/ascorbate activates UDP-glucuronyltransferase (UGT), a phenomenon totally prevented and reversed by reducing agents. At #2;M concentrations, iron and copper ions catalyze the ...
    • Inhibition of cytosolic glutathione S-transferase activity from rat liver by copper 
      Letelier Muñoz, María Eugenia; Martínez, M.; González Lira, Víctor; Faúndez, Mario; Aracena Parks, Paula (ELSEVIER, 2006-12-01)
      H2O2 inactivation of particular GST isoforms has been reported, with no information regarding the overall effect of other ROS on cytosolic GST activity. The present work describes the inactivation of total cytosolic GST ...
    • Microsomal UDP-glucuronyltransferase in rat liver: Oxidative activation 
      Letelier Muñoz, María Eugenia; Pimentel Miranda, Alejandra Patricia; Pino, Patricia; Lepe Agrodnik, Ana María; Faúndez Cáceres, Mario Antonio; Aracena Parks, Paula; Speisky Cosoy, Hernán (BLACKWELL PUBLISHING, 2005-06)
      Activation of microsomal UDP-glucuronyltransferase (UDPGT) activity by treatment of hepatic microsomes with either detergents or Fe3+/ascorbate pro-oxidant system has been reported; however, definite mechanisms underlying ...
    • Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity 
      Letelier Muñoz, María Eugenia; Lepe, Ana María; Faúndez, Mario; Salazar, Julia; Marín Catalán, Rigoberto; Aracena Parks, Paula; Speisky Cosoy, Hernán (ELSEVIER SCI IRELAND, 2005-01-15)
      It is generally accepted that copper toxicity is a consequence of the generation of reactive oxygen species (ROS) by copper ions via Fenton or Haber-Weiss reactions. Copper ions display high affinity for thiol and amino ...
    • A protocol for evaluating the safety of herbal preparations in a rat model: the case of a supercritical ... 
      Letelier Muñoz, María Eugenia; Aracena Parks, Paula; Peredo Silva, Liliana (2010)
      Herbal extracts must be evaluated for their efficacy and safety. In vivo acute toxicity studies must consider the different mechanisms by which active compounds may elicit toxicological outcomes. Thus, a methodology to ...
    • Surfactant and antioxidant properties of an extract from Chenopodium quinoa Willd seed coats 
      Letelier Muñoz, María Eugenia; Rodríguez Rojas, Carmen; Sánchez Jofré, Sebastián; Aracena Parks, Paula (ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2011-03)
      Chenopodium quinoa Willd (quinoa) has been a source of food for millennia by the Andes region native population. Because of its bitter taste, quinoa seeds are commercialized without their coat for human consumption. Quinoa ...