Browsing by Author "Carrasco Pozo, Catalina"
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Carrasco Pozo, Catalina; Gotteland, Martin; Speisky Cosoy, Hernán (2011)The aim of this work was to investigate the role of mitochondrial dysfunction in the development of oxidative stress and cytotoxicity induced by indomethacin and to evaluate the potential of an apple peel polyphenol extract ...
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Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (2008)Cu(2+) ions and and GSH molecules interact swiftly to form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing ...
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Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
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Aliaga, Margarita; Carrasco Pozo, Catalina; López Alarcón, Camilo; Olea Azar, Claudio; Speisky Cosoy, Hernán (2011)The intracellularly-occurring Cu(I)-glutathione complex (Cu(I)-[GSH](2)) has the ability to reduce molecular oxygen into superoxide radicals (O-2(center dot-)). Based on such ability, we addressed the potential of this ...