Browsing by Author "Criollo Céspedes, Alfredo"

Now showing items 1-17 of 17

    • Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis - Differential effects of ... 
      Gálvez, A. S.; Ulloa Valenzuela, Juan Alberto; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Eisner, Verónica; Barros, L.; Lavandero González, Sergio (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-10-03)
      Cells adapt to hyperosmotic conditions by several mechanisms, including accumulation of sorbitol via induction of the polyol pathway. Failure to adapt to osmotic stress can result in apoptotic cell death. In the present ...
    • Apoptosis induced by hyperosmotic stress 
      Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, Guillermo; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Calcium and mitochondrial metabolism in ceramide-induced cardiomyocyte death 
      Parra, Valentina; Moraga, Francisco; Kuzmicic, Jovan; López Crisosto, Camila; Troncoso, Rodrigo; Torrealba, Natalia; Criollo Céspedes, Alfredo; Díaz Elizondo, Jessica; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2013)
      Ceramides are important intermediates in the biosynthesis and degradation of sphingolipids that regulatenumerous cellular processes, including cell cycle progression, cell growth, differentiation and death. In ...
    • Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis 
      Parra Ortíz, María Valentina; Eisner, Verónica; Chiong Lay, Mario; Criollo Céspedes, Alfredo; Moraga, Francisco; García, Alejandra; Haertel, Steffen; Jaimovich Pérez, Enrique; Zorzano, Antonio; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2008-01-15)
      Aims In cells, mitochondria are organized as a network of interconnected organelles that fluctuate between fission and fusion events (mitochondrial dynamics). This process is associated with cell death. We investigated ...
    • Hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (ELSEVIER, 2006-06-12)
      NF kappa B is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NF kappa B pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase ...
    • Hyperosmotic stress-dependent NF kappa B activation is regulated by reactive oxygen species and IGF-1 in ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibáñez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (ELSEVIER, 2006-08-07)
      We have recently shown that hyperosmotic stress activates p65/RelB NF kappa B in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFKB is regulated in cultured ...
    • The IKK complex contributes to the induction of autophagy 
      Criollo Céspedes, Alfredo; Senovilla, Laura; Authier, Helene; Maiuri, M. C.; Morselli, E.; Vitale, I.; Kepp, O.; Tasdemir, E.; Galluzzi, Lorenzo; Shen, S.; Tailler, M.; Delahaye, N.; Tesniere, A.; De Stefano, D.; Ben Younes, Amena; Harper, F.; Pierron, G.; Lavandero González, Sergio; Zitvogel, L.; Israel, A; Baud, V; Kroemer, Guido (NATURE PUBLISHING GROUP, 2010-02-03)
      In response to stress, cells start transcriptional and transcription-independent programs that can lead to adaptation or death. Here, we show that multiple inducers of autophagy, including nutrient depletion, trigger the ...
    • The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1 
      Vicencio, José Miguel; Ortíz, C.; Criollo Céspedes, Alfredo; Jones, A. W. E.; Kepp, O.; Galluzzi, Lorenzo; Joza, N.; Vitale, I.; Morselli, E.; Tailler, M.; Castedo, M.; Maiuri, M. C.; Molgó, Jordi; Szabadkai, G.; Lavandero González, Sergio; Kroemer, Guido (NATURE PUBLISHING GROUP, 2009-07)
      The inositol 1,4,5-trisphosphate receptor (IP3R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca2+) transients from the endoplasmic ...
    • The inositol trisphosphate receptor in the control of autophagy 
      Criollo Céspedes, Alfredo; Vicencio, José Miguel; Tasdemir, E.; Maiuri, M. C.; Lavandero González, Sergio; Kroemer, Guido (LANDES BIOSCIENCE, 2007-07)
      The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the endoplasmic reticulum (ER). The IP3R agonist IP3 inhibits starvation-induced autophagy. The ...
    • Mecanismos moleculares en la apoptosis del cardiomiocito y sus proyecciones patológicas y terapéuticas 
      Maldonado, Carola; Eisner, Verónica; Gálvez, Anita; Ulloa Valenzuela, Juan Alberto; Criollo Céspedes, Alfredo; Ocaranza Osses, Paula; Eltit Ortega, José Miguel; Morales, María Paz; Quiroga Lagos, Clara; Campos Bastidas, Ximena; Chiong Lay, Mario; Sapag Hagar, Mario; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2001)
      La apoptosis junto a la paraptosis y la necrosis constituyen las principales formas de muerte celular conocidas hasta la fecha. La apoptosis se caracteriza por una disminución del volumen celular y formación de "cuerpos ...
    • Mitochondrial control of cell death induced by hyperosmotic stress 
      Criollo Céspedes, Alfredo; Galluzzi, Lorenzo; Maiuri, M. C.; Tasdemir, E.; Lavandero González, Sergio; Kroemer, Guido (SPRINGER, 2007-01)
      HeLa and HCT116 cells respond differentially to sorbitol, an osmolyte able to induce hypertonic stress. In these models, sorbitol promoted the phenotypic manifestations of early apoptosis followed by complete loss of ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 
      Bravo Sagua, Roberto; Torrealba Cárdenas, Natalia Belén; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmend, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Parallel activation of Ca2+-induced survival and death pathways in cardiomyocytes by sorbitol-induced ... 
      Chiong Lay, Mario; Parra, V.; Eisner, V.; Ibarra, C.; Maldonado, C.; Criollo Céspedes, Alfredo; Bravo, R.; Quiroga, C.; Contreras, A.; Vicencio Bustamante, José; Cea, P.; Bucarey, J.; Molgó, Jordi; Jaimovich Pérez, Enrique; Hidalgo Tapia, María Cecilia; Kroemer, G.; Lavandero González, Sergio (2010)
      Hyperosmotic stress promotes rapid and pronounced apoptosis in cultured cardiomyocytes. Here, we investigated if Ca2+ signals contribute to this response. Exposure of cardiomyocytes to sorbitol [600 mosmol (kg water)(-1)] ...
    • Regulation of autophagy by the inositol trisphosphate receptor 
      Criollo Céspedes, Alfredo; Maiuri, M. C.; Tasdemir, E.; Vitale, I.; Fiebig, A. A.; Andrews, D.; Molgó, Jordi; Díaz, J.; Lavandero González, Sergio; Harper, F.; Pierron, G.; di Stefano, D.; Rizzuto, R.; Szabadkai, G.; Kroemer, Guido (NATURE PUBLISHING GROUP, 2007-05)
      The reduction of intracellular 1,4,5-inositol trisphosphate (IP3) levels stimulates autophagy, whereas the enhancement of IP3 levels inhibits autophagy induced by nutrient depletion. Here, we show that knockdown of the ...
    • Regulation of cardiomyocyte autophagy by calcium 
      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • Senescence, Apoptosis or Autophagy? 
      Vicencio, José Miguel; Galluzzi, Lorenzo; Tajeddine, Nicolás; Ortiz, Carla; Criollo Céspedes, Alfredo; Tasdemir, E.; Morselli, Eugenia; Ben Younes, Amena; Chiara Maiuri, María; Lavandero González, Sergio; Kroemer, Guido (S. Karger AG, 2008)
      Many features of aging result from the incapacity of cells to adapt to stress conditions. When damage accumulates irreversibly, mitotic cells from renewable tissues rely on either of two mechanisms to avoid replication. ...
    • Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway 
      Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)
      The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...