Browsing by Author "Di Maio, R."

Now showing items 1-5 of 5

    • Computer assisted design of potentially active anti-trypanosomal compounds 
      Paulino, M.; Iribarne, F.; Hansz, M.; Vega, M.; Seoane, G.; Cerecetto, Hugo; Di Maio, R.; Caracelli, I.; Zukerman-Schpector, J.; Olea Azar, Claudio; Stoppani, A. O. M.; Berriman, M.; Fairlamb, A. H.; Tapia, O. (ELSEVIER SCIENCE BV, 2002-04-26)
      A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives. ...
    • Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; Di Maio, R.; Risso, Mariela; González, M.; Porcal, Williams (PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
    • ESR and spin trapping studies of two new potential antitrypanosomal drugs 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)
      The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
    • ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by ... 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Morello Casté, Antonio; Maya Arango, Juan; Moncada, C.; Cabrera, E.; Di Maio, R.; González, M.; Cerecetto, Hugo (TAYLOR & FRANCIS LTD, 2003-08)
      Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
    • Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies 
      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...