Browsing by Author "Speisky Cosoy, Hernán"

Now showing items 1-12 of 12

    • Activity of boldine on rat ileum 
      Speisky Cosoy, Hernán; Squella Serrano, Juan; Núñez Vergara, Luis (1991)
      Boldine shows a concentration-dependent relaxation effect on the rat ileum preparation with a pD2 of 3.77 ± 0.12. The alkaloid also produces a concentration-dependent parallel shift of the curve-response to acetylcholine, ...
    • Chronic exposure of HepG2 cells to excess copper results in depletion of glutathione and induction of ... 
      Jiménez T., Inés; Aracena Stiven, Paula; Letelier Muñoz, María Eugenia; Navarro, P.; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2002-04)
      Metallothionein (MT) and reduced glutathione (GSH) play an important role in the intracellular handling of copper by preventing the generation and favouring the removal of copper-derived free radicals. The present study ...
    • Determination of reactions between free radicals and selected Chilean wines and transition metals by ESR ... 
      Espinoza, Mónica; Olea Azar, Claudio; Speisky Cosoy, Hernán; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2009-01)
      Four different types of Chilean wines (Cabernet Sauvignon, Merlot, Carmenere and Syrah) were selected and examined in their free radical scavenging capacities by electron spin resonance (ESR) and spectrophotometric methods. ...
    • Effect of Dried Extract of Boldo (Peumus Boldus.Mol.) on Growth and Oxidative Tissue Status of Broiler Chickens 
      Fellenberg, M. A.; Delporte Vergara, Carla; Backhouse Erazo, Nadine; Peña, I.; Speisky Cosoy, Hernán (FACTA-FUNDACIO ARNCO CIENCIA TECNOLOGIA AVICOLAS, 2008-10)
      The addition of antioxidants to broiler diets has been shown to enhance their antioxidant status. Since boldo (Peumus boldus Mol.) leaves contain highly antioxidant molecules, a dried extract of boldo (DEB) was added to ...
    • Generation of superoxide radicals by copper-glutathione complexes: Redox-consequences associated with their ... 
      Speisky Cosoy, Hernán; Gómez, Maritza; Burgos Bravo, Francesca; López Alarcón, Camilo; Jullian Matthaei, Carolina; Olea Azar, Claudio; Aliaga, Margarita E. (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03-01)
      The interaction between Cu2+ ions and GSH molecules leads to the swift formation of the physiologically occurring Cu(I)-[GSH](2) complex. Recently, we reported that this complex is able to reduce molecular oxygen into ...
    • Microsomal UDP-glucuronyltransferase in rat liver: Oxidative activation 
      Letelier Muñoz, María Eugenia; Pimentel Miranda, Alejandra Patricia; Pino, Patricia; Lepe Agrodnik, Ana María; Faúndez Cáceres, Mario Antonio; Aracena Parks, Paula; Speisky Cosoy, Hernán (BLACKWELL PUBLISHING, 2005-06)
      Activation of microsomal UDP-glucuronyltransferase (UDPGT) activity by treatment of hepatic microsomes with either detergents or Fe3+/ascorbate pro-oxidant system has been reported; however, definite mechanisms underlying ...
    • New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological ... 
      Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)
      New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
    • NMR and molecular fluorescence spectroscopic study of the structure and thermodynamic parameters of EGCG/ ... 
      Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (Springer, 2013)
      The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like b-cyclodextrin (bCD), heptakis(2,6 di-O-methyl)-b-cyclodextrin (DMbCD), ...
    • (R)- and (S)-coclaurine from the bark of Peumus boldus 
      Asencio,; Cassels Niven, Bruce; Speisky Cosoy, Hernán; Valenzuela, (1993)
    • Reaction of 5-aminosalicylic acid with peroxyl radicals: Protection and recovery by ascorbic acid and amino acids 
      López Alarcón, Camilo; Rocco Klein, Claudio Alberto; Lissi Gervaso, Eduardo A.; Carrasco, C.; Squella Serrano, Juan; Núñez Vergara, Luis; Speisky Cosoy, Hernán (SPRINGER/PLENUM PUBLISHERS, 2005-10)
      Purpose. The aims of the study are to analyze the interaction between 5-aminosalicylic acid (5-ASA) and peroxyl radicals and to evaluate the effect of some endogenous compounds such as ascorbic acid and amino acids on the ...
    • Reactivity of 1,4-dihydropyridines toward SIN-1-derived peroxynitrite 
      López Alarcón, Camilo; Speisky Cosoy, Hernán; Squella Serrano, Juan; Olea Azar, Claudio; Camargo Grandón, Rodrigo; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 2004-10)
      Purpose. To study the reactivity of C4-substituted 1,4-dihydropyridines (1,4-DHP), with either secondary or tertiary nitrogen in the dihydropyridine ring, toward SIN-1-derived peroxynitrite in aqueous media at pH 7.4. Methods. ...
    • A system for detection of volatile antioxidant commonly emitted from spices and medicinal herbs. Un sistema ... 
      Pastene, Edgar; Gómez, Maritza; Speisky Cosoy, Hernán; Núñez Vergara, Luis (SOC BRASILEIRA QUIMICA, 2009)
      An apparatus which allows the direct measurement of the antioxidant capacity of volatiles compounds emitted from some herbs and culinary spices is described. The device comprises: a sample chamber, a mixing chamber, a pump ...