Browsing by Author "Verdejo, Hugo E."

Now showing items 1-4 of 4

    • Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy 
      Westermeier, Francisco; Navarro Márquez, Mario F.; López Crisosto, Camila; Bravo Sagua, Roberto; Quiroga Lagos, Clara; Bustamante, Mario; Verdejo, Hugo E.; Zalaquett Sepúlveda, Ricardo; Ibacache, Mauricio; Parra Ortíz, María Valentina; Castro, Pablo F.; Rothermel, Beverly A.; Hill, Joseph A.; Lavandero González, Sergio (Elsevier, 2015)
      Diabetic cardiomyopathy (DCM) is a common consequence of longstanding type 2 diabetes mellitus (T2DM) and encompasses structural, morphological, functional, and metabolic abnormalities in the heart.Myocardial energy metabolism ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases ... 
      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through ... 
      Campo Sfeir, Andrea Estefanía del; Parra Ortíz, María Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (American Physiological Society, 2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Xanthine-oxidase inhibitors and statins in chronic heart failure: Effects on vascular and functional parameters 
      Greig, Douglas; Alcaíno Gálvez, Hernán Alejandro; Castro Gálvez, Pablo; García Nannig, Lorena; Verdejo, Hugo E.; Navarro, Mario; López, Rafael; Mellado, Rose Marie; Tapia Mamani, Fabiola Karina; Gabrielli, Luigi A.; Nogerol, Camilo; Chiong Lay, Mario; Godoy, Iván; Lavandero González, Sergio (ELSEVIER SCIENCE INC, 2011-04)
      Increased oxidative stress in heart failure (HF) leads to inflammation and endothelial dysfunction (ED). Both statins and allopurinol have known anti-oxidant properties, but their utility in HF has not been fully assessed.